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Coexpression cluster:C144

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Full id: C144_CD4_tonsil_NK_appendix_CD8_splenic_mycosis



Phase1 CAGE Peaks

Hg19::chr10:6114599..6114604,+p@chr10:6114599..6114604
+
Hg19::chr10:75255272..75255287,-p@chr10:75255272..75255287
-
Hg19::chr11:4111694..4111720,+p@chr11:4111694..4111720
+
Hg19::chr11:76284493..76284520,-p@chr11:76284493..76284520
-
Hg19::chr11:76284523..76284532,-p@chr11:76284523..76284532
-
Hg19::chr12:50336994..50337003,+p@chr12:50336994..50337003
+
Hg19::chr12:50337005..50337016,+p@chr12:50337005..50337016
+
Hg19::chr12:50337021..50337036,+p@chr12:50337021..50337036
+
Hg19::chr12:58102607..58102613,+p@chr12:58102607..58102613
+
Hg19::chr12:58102624..58102632,+p@chr12:58102624..58102632
+
Hg19::chr12:58102635..58102654,+p@chr12:58102635..58102654
+
Hg19::chr12:58102662..58102674,+p@chr12:58102662..58102674
+
Hg19::chr12:58102682..58102689,+p@chr12:58102682..58102689
+
Hg19::chr12:99139620..99139633,-p29@ANKS1B
Hg19::chr13:113840580..113840595,-p11@PCID2
Hg19::chr13:73573059..73573073,+p@chr13:73573059..73573073
+
Hg19::chr13:75890666..75890681,-p23@TBC1D4
Hg19::chr13:75890689..75890698,-p22@TBC1D4
Hg19::chr13:75890705..75890726,-p8@TBC1D4
Hg19::chr13:75890730..75890751,-p11@TBC1D4
Hg19::chr13:99966972..99966986,+p10@UBAC2
Hg19::chr14:106069896..106069928,-p@chr14:106069896..106069928
-
Hg19::chr14:22443217..22443229,+p@chr14:22443217..22443229
+
Hg19::chr14:66335008..66335022,+p@chr14:66335008..66335022
+
Hg19::chr14:66342511..66342535,+p@chr14:66342511..66342535
+
Hg19::chr14:66384160..66384166,+p@chr14:66384160..66384166
+
Hg19::chr14:66473382..66473386,+p@chr14:66473382..66473386
+
Hg19::chr14:69246886..69246901,-p@chr14:69246886..69246901
-
Hg19::chr14:69246908..69246919,-p@chr14:69246908..69246919
-
Hg19::chr15:34628951..34628970,-p21@SLC12A6
Hg19::chr15:38988723..38988728,+p3@C15orf53
Hg19::chr15:38988768..38988793,+p1@C15orf53
Hg19::chr15:38988801..38988810,+p2@C15orf53
Hg19::chr15:38997190..38997193,+p@chr15:38997190..38997193
+
Hg19::chr15:39142027..39142030,+p@chr15:39142027..39142030
+
Hg19::chr15:39179946..39179951,+p@chr15:39179946..39179951
+
Hg19::chr15:39188204..39188208,+p@chr15:39188204..39188208
+
Hg19::chr15:39196210..39196213,+p@chr15:39196210..39196213
+
Hg19::chr15:39260074..39260077,+p@chr15:39260074..39260077
+
Hg19::chr15:39316251..39316255,+p@chr15:39316251..39316255
+
Hg19::chr15:45028697..45028709,+p10@TRIM69
Hg19::chr15:52549283..52549293,-p5@MYO5C
Hg19::chr15:74919872..74919883,+p@chr15:74919872..74919883
+
Hg19::chr15:91415990..91416002,+p4@FURIN
Hg19::chr16:12633178..12633179,+p@chr16:12633178..12633179
+
Hg19::chr16:12633181..12633216,+p@chr16:12633181..12633216
+
Hg19::chr16:12633220..12633234,+p@chr16:12633220..12633234
+
Hg19::chr16:3119275..3119289,+p@chr16:3119275..3119289
+
Hg19::chr16:31265094..31265102,+p@chr16:31265094..31265102
+
Hg19::chr16:31265115..31265130,+p@chr16:31265115..31265130
+
Hg19::chr16:68390585..68390598,+p@chr16:68390585..68390598
+
Hg19::chr16:68390609..68390614,+p@chr16:68390609..68390614
+
Hg19::chr17:14023072..14023081,+p@chr17:14023072..14023081
+
Hg19::chr17:17082930..17082936,+p@chr17:17082930..17082936
+
Hg19::chr17:18247551..18247560,-p@chr17:18247551..18247560
-
Hg19::chr17:18247561..18247571,-p@chr17:18247561..18247571
-
Hg19::chr17:36853518..36853526,-p@chr17:36853518..36853526
-
Hg19::chr17:37947726..37947743,-p@chr17:37947726..37947743
-
Hg19::chr17:37949241..37949253,-p@chr17:37949241..37949253
-
Hg19::chr17:37949262..37949283,-p@chr17:37949262..37949283
-
Hg19::chr17:57905350..57905362,-p@chr17:57905350..57905362
-
Hg19::chr19:19779686..19779697,+p3@ZNF101
Hg19::chr19:3177362..3177366,+p@chr19:3177362..3177366
+
Hg19::chr19:38917975..38917982,-p@chr19:38917975..38917982
-
Hg19::chr19:38917995..38918006,-p@chr19:38917995..38918006
-
Hg19::chr19:41963286..41963299,-p@chr19:41963286..41963299
-
Hg19::chr19:41963314..41963323,-p@chr19:41963314..41963323
-
Hg19::chr1:110456600..110456612,+p19@CSF1
Hg19::chr1:112145782..112145793,-p@chr1:112145782..112145793
-
Hg19::chr1:9000012..9000016,+p@chr1:9000012..9000016
+
Hg19::chr20:17944380..17944396,-p@chr20:17944380..17944396
-
Hg19::chr20:48211053..48211065,+p@chr20:48211053..48211065
+
Hg19::chr20:48211074..48211083,+p@chr20:48211074..48211083
+
Hg19::chr20:48211099..48211112,+p@chr20:48211099..48211112
+
Hg19::chr20:48211124..48211159,+p@chr20:48211124..48211159
+
Hg19::chr20:48211160..48211182,+p@chr20:48211160..48211182
+
Hg19::chr22:46983792..46983802,+p@chr22:46983792..46983802
+
Hg19::chr2:101967791..101967807,-p@chr2:101967791..101967807
-
Hg19::chr2:102624993..102625009,+p6@IL1R2
Hg19::chr2:204718100..204718122,+p@chr2:204718100..204718122
+
Hg19::chr2:204718611..204718622,+p@chr2:204718611..204718622
+
Hg19::chr2:204718629..204718648,+p@chr2:204718629..204718648
+
Hg19::chr2:204718657..204718664,+p@chr2:204718657..204718664
+
Hg19::chr2:204718667..204718689,+p@chr2:204718667..204718689
+
Hg19::chr2:204718709..204718716,+p@chr2:204718709..204718716
+
Hg19::chr2:204720243..204720258,+p@chr2:204720243..204720258
+
Hg19::chr2:241976174..241976202,+p7@SNED1
Hg19::chr2:28837255..28837277,-p@chr2:28837255..28837277
-
Hg19::chr2:86696032..86696046,+p@chr2:86696032..86696046
+
Hg19::chr3:194204893..194204913,+p@chr3:194204893..194204913
+
Hg19::chr3:195018381..195018405,-p@chr3:195018381..195018405
-
Hg19::chr3:32543051..32543061,-p@chr3:32543051..32543061
-
Hg19::chr3:32995025..32995046,+p1@AB464482
p1@CU687156
Hg19::chr3:33061467..33061496,+p@chr3:33061467..33061496
+
Hg19::chr3:33063435..33063443,-p@chr3:33063435..33063443
-
Hg19::chr3:33064076..33064077,+p@chr3:33064076..33064077
+
Hg19::chr3:50647738..50647778,-p@chr3:50647738..50647778
-
Hg19::chr4:90228214..90228230,-p@chr4:90228214..90228230
-
Hg19::chr5:131878918..131878934,-p@chr5:131878918..131878934
-
Hg19::chr5:132009675..132009687,+p1@IL4
Hg19::chr5:66124481..66124523,-p@chr5:66124481..66124523
-
Hg19::chr5:66124998..66125007,+p@chr5:66124998..66125007
+
Hg19::chr5:79286163..79286172,-p@chr5:79286163..79286172
-
Hg19::chr6:11788124..11788142,-p@chr6:11788124..11788142
-
Hg19::chr6:149457920..149457945,-p@chr6:149457920..149457945
-
Hg19::chr6:149523352..149523377,-p@chr6:149523352..149523377
-
Hg19::chr6:167536230..167536251,+p5@CCR6
Hg19::chr6:34639750..34639779,-p5@C6orf106
Hg19::chr7:44663643..44663674,+p4@OGDH
Hg19::chr8:38216954..38216982,-p@chr8:38216954..38216982
-
Hg19::chr8:38216992..38217013,-p@chr8:38216992..38217013
-
Hg19::chr9:134552199..134552210,-p@chr9:134552199..134552210
-
Hg19::chr9:139001783..139001802,+p@chr9:139001783..139001802
+
Hg19::chrX:49107434..49107439,-p@chrX:49107434..49107439
-
Hg19::chrX:49107447..49107461,-p@chrX:49107447..49107461
-
Hg19::chrX:49113914..49113920,-p@chrX:49113914..49113920
-
Hg19::chrX:49121165..49121179,-p1@FOXP3
Hg19::chrY:23411611..23411629,+p@chrY:23411611..23411629
+
Hg19::chrY:23411674..23411684,+p@chrY:23411674..23411684
+
Hg19::chrY:23415362..23415365,+p@chrY:23415362..23415365
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

p.valueFDRnGenesnPathwayName
2.00529016035634e-050.00707001735823384265Cytokine-cytokine receptor interaction (KEGG):04060
2.23381275141668e-050.0070700173582338388Hematopoietic cell lineage (KEGG):04640
9.42667556910383e-050.0198902854508091223Cytokines and Inflammatory Response (Wikipathways):WP530



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0002440production of molecular mediator of immune response0.00683967092024917
GO:0006417regulation of translation0.00683967092024917
GO:0002573myeloid leukocyte differentiation0.00683967092024917
GO:0031326regulation of cellular biosynthetic process0.00683967092024917
GO:0042129regulation of T cell proliferation0.00683967092024917
GO:0009889regulation of biosynthetic process0.00683967092024917
GO:0042098T cell proliferation0.00683967092024917
GO:0017148negative regulation of translation0.00683967092024917
GO:0032944regulation of mononuclear cell proliferation0.00683967092024917
GO:0050670regulation of lymphocyte proliferation0.00683967092024917
GO:0031327negative regulation of cellular biosynthetic process0.00683967092024917
GO:0009890negative regulation of biosynthetic process0.00683967092024917
GO:0002376immune system process0.00683967092024917
GO:0032943mononuclear cell proliferation0.00683967092024917
GO:0046651lymphocyte proliferation0.00683967092024917
GO:0050863regulation of T cell activation0.00683967092024917
GO:0042089cytokine biosynthetic process0.00683967092024917
GO:0042107cytokine metabolic process0.00683967092024917
GO:0005157macrophage colony stimulating factor receptor binding0.00683967092024917
GO:0032693negative regulation of interleukin-10 production0.00683967092024917
GO:0050164oxoglutarate dehydrogenase (NADP+) activity0.00683967092024917
GO:0032689negative regulation of interferon-gamma production0.00683967092024917
GO:0032673regulation of interleukin-4 production0.00683967092024917
GO:0032601connective tissue growth factor production0.00683967092024917
GO:0005136interleukin-4 receptor binding0.00683967092024917
GO:0004276furin activity0.00683967092024917
GO:0002725negative regulation of T cell cytokine production0.00683967092024917
GO:0032713negative regulation of interleukin-4 production0.00683967092024917
GO:0045189connective tissue growth factor biosynthetic process0.00683967092024917
GO:0051525NFAT protein binding0.00683967092024917
GO:0032804negative regulation of low-density lipoprotein receptor catabolic process0.00683967092024917
GO:0046007negative regulation of activated T cell proliferation0.00683967092024917
GO:0006968cellular defense response0.00683967092024917
GO:0002449lymphocyte mediated immunity0.00683967092024917
GO:0002250adaptive immune response0.00699486912992422
GO:0002460adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.00699486912992422
GO:0051249regulation of lymphocyte activation0.00699486912992422
GO:0030099myeloid cell differentiation0.00699486912992422
GO:0002443leukocyte mediated immunity0.00699486912992422
GO:0050865regulation of cell activation0.00717289543612794
GO:0002521leukocyte differentiation0.00774819298077369
GO:0051246regulation of protein metabolic process0.00774819298077369
GO:0042110T cell activation0.00774819298077369
GO:0050776regulation of immune response0.00774819298077369
GO:0019955cytokine binding0.00774819298077369
GO:0002682regulation of immune system process0.00774819298077369
GO:0032653regulation of interleukin-10 production0.00774819298077369
GO:0004910interleukin-1, Type II, blocking receptor activity0.00774819298077369
GO:0032803regulation of low-density lipoprotein receptor catabolic process0.00774819298077369
GO:0002704negative regulation of leukocyte mediated immunity0.00774819298077369
GO:0032703negative regulation of interleukin-2 production0.00774819298077369
GO:0032801receptor catabolic process0.00774819298077369
GO:0002710negative regulation of T cell mediated immunity0.00774819298077369
GO:0048295positive regulation of isotype switching to IgE isotypes0.00774819298077369
GO:0002707negative regulation of lymphocyte mediated immunity0.00774819298077369
GO:0032802low-density lipoprotein receptor catabolic process0.00774819298077369
GO:0032792inhibition of CREB transcription factor0.00774819298077369
GO:0019968interleukin-1, Type II, blocking binding0.00774819298077369
GO:0051248negative regulation of protein metabolic process0.00819216705586183
GO:0042127regulation of cell proliferation0.00885534337479167
GO:0002252immune effector process0.00885534337479167
GO:0001816cytokine production0.0090803420662768
GO:0042592homeostatic process0.0090803420662768
GO:0032799low-density lipoprotein receptor metabolic process0.00949230836421774
GO:0048289isotype switching to IgE isotypes0.00949230836421774
GO:0002701negative regulation of production of molecular mediator of immune response0.00949230836421774
GO:0016565general transcriptional repressor activity0.00949230836421774
GO:0048293regulation of isotype switching to IgE isotypes0.00949230836421774
GO:0045085negative regulation of interleukin-2 biosynthetic process0.00949230836421774
GO:0048304positive regulation of isotype switching to IgG isotypes0.00949230836421774
GO:0002719negative regulation of cytokine production during immune response0.00949230836421774
GO:0006955immune response0.0105740373439106
GO:0050710negative regulation of cytokine secretion0.0113544630907996
GO:0048302regulation of isotype switching to IgG isotypes0.0113544630907996
GO:0015379potassium:chloride symporter activity0.0113544630907996
GO:0032633interleukin-4 production0.0113544630907996
GO:0002698negative regulation of immune effector process0.0113544630907996
GO:0032088inhibition of NF-kappaB transcription factor0.0113544630907996
GO:0048291isotype switching to IgG isotypes0.0113544630907996
GO:0042330taxis0.0113544630907996
GO:0006935chemotaxis0.0113544630907996
GO:0046649lymphocyte activation0.01275901911404
GO:0002820negative regulation of adaptive immune response0.01275901911404
GO:0002369T cell cytokine production0.01275901911404
GO:0032613interleukin-10 production0.01275901911404
GO:0045348positive regulation of MHC class II biosynthetic process0.01275901911404
GO:0002823negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.01275901911404
GO:0002724regulation of T cell cytokine production0.01275901911404
GO:0030097hemopoiesis0.0128714643838124
GO:0048534hemopoietic or lymphoid organ development0.0136068165663078
GO:0045342MHC class II biosynthetic process0.0136068165663078
GO:0045830positive regulation of isotype switching0.0136068165663078
GO:0045346regulation of MHC class II biosynthetic process0.0136068165663078
GO:0002709regulation of T cell mediated immunity0.0136068165663078
GO:0050709negative regulation of protein secretion0.0136068165663078
GO:0006884regulation of cell volume0.0136068165663078
GO:0043029T cell homeostasis0.0136068165663078
GO:0032663regulation of interleukin-2 production0.0136068165663078
GO:0032649regulation of interferon-gamma production0.0136068165663078
GO:0045321leukocyte activation0.0142592197625642
GO:0007626locomotory behavior0.0142721472839673
GO:0002520immune system development0.0142856100530098
GO:0046006regulation of activated T cell proliferation0.0148232410809889
GO:0045671negative regulation of osteoclast differentiation0.0148232410809889
GO:0004591oxoglutarate dehydrogenase (succinyl-transferring) activity0.0148232410809889
GO:0050798activated T cell proliferation0.0148232410809889
GO:0042130negative regulation of T cell proliferation0.0166237024164733
GO:0004908interleukin-1 receptor activity0.0166237024164733
GO:0001775cell activation0.0167419623278427
GO:0008283cell proliferation0.0167419623278427
GO:0002718regulation of cytokine production during immune response0.0167419623278427
GO:0002700regulation of production of molecular mediator of immune response0.0167419623278427
GO:0045670regulation of osteoclast differentiation0.0167419623278427
GO:0004945angiotensin type II receptor activity0.0167419623278427
GO:0001595angiotensin receptor activity0.0167419623278427
GO:0050777negative regulation of immune response0.0167419623278427
GO:0002762negative regulation of myeloid leukocyte differentiation0.0167419623278427
GO:0045191regulation of isotype switching0.0167419623278427
GO:0002367cytokine production during immune response0.0167419623278427
GO:0030890positive regulation of B cell proliferation0.0167419623278427
GO:0065007biological regulation0.0167419623278427
GO:0002683negative regulation of immune system process0.0174971254258332
GO:0042092T-helper 2 type immune response0.0174971254258332
GO:0002456T cell mediated immunity0.0174971254258332
GO:0019966interleukin-1 binding0.0174971254258332
GO:0002260lymphocyte homeostasis0.0174971254258332
GO:0001818negative regulation of cytokine production0.0174971254258332
GO:0030888regulation of B cell proliferation0.0174971254258332
GO:0008284positive regulation of cell proliferation0.0174971254258332
GO:0006873cellular ion homeostasis0.0174971254258332
GO:0055082cellular chemical homeostasis0.0174971254258332
GO:0043112receptor metabolic process0.0174971254258332
GO:0030316osteoclast differentiation0.0174971254258332
GO:0002208somatic diversification of immunoglobulins during immune response0.0174971254258332
GO:0002381immunoglobulin production during immune response0.0174971254258332
GO:0050868negative regulation of T cell activation0.0174971254258332
GO:0030225macrophage differentiation0.0174971254258332
GO:0050672negative regulation of lymphocyte proliferation0.0174971254258332
GO:0002204somatic recombination of immunoglobulin genes during immune response0.0174971254258332
GO:0045190isotype switching0.0174971254258332
GO:0032945negative regulation of mononuclear cell proliferation0.0174971254258332
GO:0002703regulation of leukocyte mediated immunity0.0186862618924103
GO:0002706regulation of lymphocyte mediated immunity0.0186862618924103
GO:0015377cation:chloride symporter activity0.0186862618924103
GO:0008083growth factor activity0.0191008012011806
GO:0016447somatic recombination of immunoglobulin gene segments0.0196922737065576
GO:0002819regulation of adaptive immune response0.0196922737065576
GO:0002822regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.0.0196922737065576
GO:0050801ion homeostasis0.0206327863999324
GO:0001776leukocyte homeostasis0.0209199940569343
GO:0005515protein binding0.0210090596731958
GO:0051239regulation of multicellular organismal process0.0210090596731958
GO:0045941positive regulation of transcription0.0210090596731958
GO:0016444somatic cell DNA recombination0.0210090596731958
GO:0048872homeostasis of number of cells0.0210090596731958
GO:0016445somatic diversification of immunoglobulins0.0210090596731958
GO:0045076regulation of interleukin-2 biosynthetic process0.0210090596731958
GO:0002697regulation of immune effector process0.0210090596731958
GO:0002761regulation of myeloid leukocyte differentiation0.0210090596731958
GO:0002562somatic diversification of immune receptors via germline recombination within a single locus0.0210090596731958
GO:0045935positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0214659153375232
GO:0042094interleukin-2 biosynthetic process0.0214659153375232
GO:0002200somatic diversification of immune receptors0.0214659153375232
GO:0043433negative regulation of transcription factor activity0.0214659153375232
GO:0006465signal peptide processing0.0214659153375232
GO:0050707regulation of cytokine secretion0.0214659153375232
GO:0042036negative regulation of cytokine biosynthetic process0.0214659153375232
GO:0007610behavior0.022043145403191
GO:0051048negative regulation of secretion0.0225329827501509
GO:0048878chemical homeostasis0.0226474620966088
GO:0065008regulation of biological quality0.0226474620966088
GO:0048522positive regulation of cellular process0.0226474620966088
GO:0051059NF-kappaB binding0.0226474620966088
GO:0002377immunoglobulin production0.0226474620966088
GO:0050871positive regulation of B cell activation0.0226474620966088
GO:0032609interferon-gamma production0.0226474620966088
GO:0042100B cell proliferation0.0226474620966088
GO:0045638negative regulation of myeloid cell differentiation0.0226474620966088
GO:0005125cytokine activity0.0229122396093299
GO:0051250negative regulation of lymphocyte activation0.0236351688993002
GO:0050663cytokine secretion0.0247365777129357
GO:0032623interleukin-2 production0.0256842556334335
GO:0016624oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor0.0256842556334335
GO:0048518positive regulation of biological process0.0288621617302424
GO:0019957C-C chemokine binding0.0288621617302424
GO:0016493C-C chemokine receptor activity0.0288621617302424
GO:0051241negative regulation of multicellular organismal process0.0295234892360718
GO:0042102positive regulation of T cell proliferation0.0295234892360718
GO:0050864regulation of B cell activation0.0295234892360718
GO:0031325positive regulation of cellular metabolic process0.0295234892360718
GO:0050708regulation of protein secretion0.0304362923968099
GO:0019725cellular homeostasis0.0307627271557973
GO:0031324negative regulation of cellular metabolic process0.031543669199429
GO:0006518peptide metabolic process0.0322573951588899
GO:0009893positive regulation of metabolic process0.032689212371392
GO:0048523negative regulation of cellular process0.032689212371392
GO:0030183B cell differentiation0.032727770443523
GO:0030140trans-Golgi network transport vesicle0.032727770443523
GO:0032946positive regulation of mononuclear cell proliferation0.0335108540097155
GO:0050671positive regulation of lymphocyte proliferation0.0335108540097155
GO:0048519negative regulation of biological process0.0353893559769884
GO:0006412translation0.0372036479975713
GO:0045637regulation of myeloid cell differentiation0.0372036479975713
GO:0004907interleukin receptor activity0.0372036479975713
GO:0004289subtilase activity0.0381032136950474
GO:0009892negative regulation of metabolic process0.0381769303645508
GO:0004950chemokine receptor activity0.0386186634662823
GO:0001637G-protein chemoattractant receptor activity0.0386186634662823
GO:0006066alcohol metabolic process0.0391107838973536
GO:0019956chemokine binding0.0403593060030109
GO:0015296anion:cation symporter activity0.0410221858338763
GO:0051015actin filament binding0.0410221858338763
GO:0019965interleukin binding0.0418678931946746
GO:0050870positive regulation of T cell activation0.0425066411937473
GO:0001817regulation of cytokine production0.0425066411937473



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
leukocyte1.05e-46140
hematopoietic stem cell2.05e-46172
angioblastic mesenchymal cell2.05e-46172
hematopoietic cell1.01e-44182
hematopoietic oligopotent progenitor cell1.77e-44165
hematopoietic multipotent progenitor cell1.77e-44165
nongranular leukocyte2.63e-39119
hematopoietic lineage restricted progenitor cell5.58e-39124
lymphocyte2.97e-2653
common lymphoid progenitor2.97e-2653
lymphoid lineage restricted progenitor cell7.21e-2652
myeloid cell5.66e-19112
common myeloid progenitor5.66e-19112
myeloid leukocyte6.88e-1676
granulocyte monocyte progenitor cell9.53e-1571
T cell5.21e-1425
pro-T cell5.21e-1425
myeloid lineage restricted progenitor cell1.54e-1370
macrophage dendritic cell progenitor1.84e-1365
monopoietic cell1.16e-1263
monocyte1.16e-1263
monoblast1.16e-1263
promonocyte1.16e-1263
mature alpha-beta T cell3.24e-1218
alpha-beta T cell3.24e-1218
immature T cell3.24e-1218
mature T cell3.24e-1218
immature alpha-beta T cell3.24e-1218
lymphocyte of B lineage2.61e-1124
pro-B cell2.61e-1124
CD14-positive, CD16-negative classical monocyte1.20e-0942
classical monocyte3.13e-0945
CD8-positive, alpha-beta T cell9.54e-0811
B cell2.27e-0714
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.16e-21102
blood island1.16e-21102
hemolymphoid system1.21e-19112
adult organism8.80e-14115
bone marrow1.57e-1180
immune system2.28e-10115
blood1.24e-0915
haemolymphatic fluid1.24e-0915
organism substance1.24e-0915
bone element1.26e-0986
skeletal element7.81e-07101
skeletal system7.81e-07101
lateral plate mesoderm9.34e-07216
Disease
Ontology termp-valuen
hematologic cancer1.37e-0751
immune system cancer1.37e-0751


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538122.435780179230360.003959696132274990.0190066506277538



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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