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Coexpression cluster:C416

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Full id: C416_CD4_Neutrophils_CD8_Natural_CD19_CD14_Peripheral



Phase1 CAGE Peaks

Hg19::chr12:432372..432377,-p3@KDM5A
Hg19::chr14:58759862..58759865,-p@chr14:58759862..58759865
-
Hg19::chr15:63867377..63867381,+p@chr15:63867377..63867381
+
Hg19::chr15:93440362..93440368,+p@chr15:93440362..93440368
+
Hg19::chr16:89942255..89942258,+p@chr16:89942255..89942258
+
Hg19::chr17:47907569..47907575,+p@chr17:47907569..47907575
+
Hg19::chr17:76693404..76693408,-p@chr17:76693404..76693408
-
Hg19::chr19:16720749..16720753,-p@chr19:16720749..16720753
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Hg19::chr1:14085673..14085677,+p@chr1:14085673..14085677
+
Hg19::chr1:171455261..171455278,+p@chr1:171455261..171455278
+
Hg19::chr1:65394459..65394461,-p@chr1:65394459..65394461
-
Hg19::chr1:67405973..67405977,+p@chr1:67405973..67405977
+
Hg19::chr2:197017976..197017980,-p@chr2:197017976..197017980
-
Hg19::chr2:225422591..225422605,-p8@CUL3
Hg19::chr2:225434670..225434674,-p6@CUL3
Hg19::chr2:54194783..54194785,-p@chr2:54194783..54194785
-
Hg19::chr5:93340701..93340703,-p@chr5:93340701..93340703
-
Hg19::chr6:131948461..131948465,-p@chr6:131948461..131948465
-
Hg19::chr6:155101505..155101509,+p@chr6:155101505..155101509
+
Hg19::chr6:4022409..4022413,+p@chr6:4022409..4022413
+
Hg19::chr7:151950594..151950600,-p@chr7:151950594..151950600
-
Hg19::chr7:155448253..155448257,+p@chr7:155448253..155448257
+
Hg19::chr7:32912993..32912997,-p@chr7:32912993..32912997
-
Hg19::chr9:86593238..86593252,-p3@HNRNPK
Hg19::chrX:70754993..70754996,+p@chrX:70754993..70754996
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0031461cullin-RING ubiquitin ligase complex0.0203991522430237
GO:0031625ubiquitin protein ligase binding0.0203991522430237
GO:0000082G1/S transition of mitotic cell cycle0.0203991522430237
GO:0008629induction of apoptosis by intracellular signals0.0203991522430237
GO:0000151ubiquitin ligase complex0.0286154774520193
GO:0051329interphase of mitotic cell cycle0.0286154774520193
GO:0051325interphase0.0286154774520193
GO:0007050cell cycle arrest0.0286154774520193
GO:0006917induction of apoptosis0.0334546096785588
GO:0012502induction of programmed cell death0.0334546096785588
GO:0045786negative regulation of progression through cell cycle0.0334546096785588
GO:0008284positive regulation of cell proliferation0.0334546096785588
GO:0043065positive regulation of apoptosis0.0334546096785588
GO:0043068positive regulation of programmed cell death0.0334546096785588
GO:0006511ubiquitin-dependent protein catabolic process0.0334546096785588
GO:0043632modification-dependent macromolecule catabolic process0.0334546096785588
GO:0019941modification-dependent protein catabolic process0.0334546096785588
GO:0051603proteolysis involved in cellular protein catabolic process0.0334546096785588
GO:0044257cellular protein catabolic process0.0334546096785588
GO:0019899enzyme binding0.0334546096785588
GO:0000278mitotic cell cycle0.0334546096785588
GO:0000074regulation of progression through cell cycle0.0334546096785588
GO:0030163protein catabolic process0.0334546096785588
GO:0051726regulation of cell cycle0.0334546096785588
GO:0022403cell cycle phase0.0334546096785588
GO:0043285biopolymer catabolic process0.0393712033003214
GO:0042127regulation of cell proliferation0.0393712033003214
GO:0044265cellular macromolecule catabolic process0.0421143788243069
GO:0006512ubiquitin cycle0.0421143788243069
GO:0042981regulation of apoptosis0.0421143788243069
GO:0043067regulation of programmed cell death0.0421143788243069
GO:0022402cell cycle process0.0429275089289218
GO:0009057macromolecule catabolic process0.0429275089289218
GO:0005794Golgi apparatus0.0463314078722269
GO:0008283cell proliferation0.0482456140350877



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte3.08e-45140
hematopoietic stem cell3.63e-43172
angioblastic mesenchymal cell3.63e-43172
hematopoietic oligopotent progenitor cell4.31e-39165
hematopoietic multipotent progenitor cell4.31e-39165
hematopoietic cell1.96e-38182
hematopoietic lineage restricted progenitor cell6.15e-37124
nongranular leukocyte1.44e-36119
myeloid leukocyte2.62e-2176
CD14-positive, CD16-negative classical monocyte1.60e-2042
myeloid cell2.11e-20112
common myeloid progenitor2.11e-20112
classical monocyte3.51e-1945
lymphocyte7.84e-1853
common lymphoid progenitor7.84e-1853
myeloid lineage restricted progenitor cell9.05e-1870
lymphoid lineage restricted progenitor cell9.35e-1852
macrophage dendritic cell progenitor1.94e-1765
granulocyte monocyte progenitor cell2.48e-1771
monopoietic cell1.50e-1663
monocyte1.50e-1663
monoblast1.50e-1663
promonocyte1.50e-1663
mature alpha-beta T cell3.26e-0918
alpha-beta T cell3.26e-0918
immature T cell3.26e-0918
mature T cell3.26e-0918
immature alpha-beta T cell3.26e-0918
T cell3.60e-0925
pro-T cell3.60e-0925
lymphocyte of B lineage4.38e-0824
pro-B cell4.38e-0824
intermediate monocyte7.11e-079
CD14-positive, CD16-positive monocyte7.11e-079
Uber Anatomy
Ontology termp-valuen
hematopoietic system3.71e-21102
blood island3.71e-21102
hemolymphoid system1.81e-19112
bone marrow4.27e-1480
bone element1.42e-1386
immune system4.67e-11115
adult organism1.66e-09115
skeletal element3.97e-09101
skeletal system3.97e-09101
blood1.37e-0715
haemolymphatic fluid1.37e-0715
organism substance1.37e-0715


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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