MCL coexpression mm9:845

Phase1 CAGE Peaks

	Short description
Mm9::chr2:71367605..71367621,+	p9@Dlx1
Mm9::chr2:71367646..71367658,+	p11@Dlx1
Mm9::chr2:71367712..71367725,-	p@chr2:71367712..71367725 -
Mm9::chr2:71367855..71367864,+	p6@Dlx1
Mm9::chr2:71367871..71367898,+	p1@Dlx1
Mm9::chr2:71384401..71384424,-	p3@Dlx2
Mm9::chr2:71384425..71384456,-	p4@Dlx2
Mm9::chr2:71384458..71384526,-	p2@Dlx2
Mm9::chr3:103379198..103379209,+	p2@Syt6

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0003682	chromatin binding	0.0100113843144172
GO:0048306	calcium-dependent protein binding	0.0377534594233227
GO:0005667	transcription factor complex	0.0377534594233227
GO:0043565	sequence-specific DNA binding	0.0377534594233227
GO:0007340	acrosome reaction	0.0377534594233227
GO:0003727	single-stranded RNA binding	0.0377534594233227
GO:0044451	nucleoplasm part	0.0377534594233227
GO:0005654	nucleoplasm	0.0377534594233227
GO:0017156	calcium ion-dependent exocytosis	0.039472660718551
GO:0031981	nuclear lumen	0.039472660718551
GO:0043524	negative regulation of neuron apoptosis	0.039472660718551
GO:0031974	membrane-enclosed lumen	0.041487927027033
GO:0043233	organelle lumen	0.041487927027033
GO:0043523	regulation of neuron apoptosis	0.0432655166342465
GO:0003700	transcription factor activity	0.0432655166342465
GO:0051402	neuron apoptosis	0.0447989412981176
GO:0007338	single fertilization	0.0454849411957286
GO:0009566	fertilization	0.0497183098655478
GO:0044428	nuclear part	0.0497183098655478
GO:0008021	synaptic vesicle	0.0499450898651755

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
ectodermal cell	6.32e-12	44
neurectodermal cell	6.32e-12	44
neural cell	2.99e-11	43
non-terminally differentiated cell	3.53e-11	49
neuron	3.96e-11	33
neuronal stem cell	3.96e-11	33
neuroblast	3.96e-11	33
electrically signaling cell	3.96e-11	33
electrically responsive cell	7.66e-11	39
electrically active cell	7.66e-11	39
autonomic neuron	3.24e-10	9
neuron of cerebral cortex	2.99e-07	6

Uber Anatomy

Ontology term	p-value	n
ectoderm-derived structure	6.70e-16	95
ectoderm	6.70e-16	95
presumptive ectoderm	6.70e-16	95
nervous system	7.94e-14	75
central nervous system	6.47e-13	73
pre-chordal neural plate	1.00e-12	49
ecto-epithelium	5.07e-12	73
brain grey matter	2.13e-11	29
regional part of telencephalon	2.13e-11	29
telencephalon	2.13e-11	29
peripheral nervous system	5.44e-11	11
neurectoderm	6.93e-11	64
neural plate	6.93e-11	64
presumptive neural plate	6.93e-11	64
anterior neural tube	1.38e-10	40
regional part of forebrain	2.58e-10	39
forebrain	2.58e-10	39
future forebrain	2.58e-10	39
autonomic nervous system	3.24e-10	9
brain	8.22e-10	47
future brain	8.22e-10	47
regional part of brain	4.23e-09	46
gray matter	1.25e-08	34
neural tube	4.61e-07	52
neural rod	4.61e-07	52
future spinal cord	4.61e-07	52
neural keel	4.61e-07	52
regional part of nervous system	5.07e-07	54
cerebral cortex	7.49e-07	21
cerebral hemisphere	7.49e-07	21
pallium	7.49e-07	21

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}