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MCL coexpression mm9:1893

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Phase1 CAGE Peaks

 Short description
Mm9::chr10:57351852..57351866,+p3@Pkib
Mm9::chr10:57351868..57351907,+p1@Pkib
Mm9::chr10:57351914..57351926,+p5@Pkib
Mm9::chr12:99813245..99813258,-p6@Kcnk10


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0004862cAMP-dependent protein kinase inhibitor activity0.0121617179066112
GO:0004860protein kinase inhibitor activity0.0256501195402001
GO:0019210kinase inhibitor activity0.0256501195402001
GO:0006469negative regulation of protein kinase activity0.0256501195402001
GO:0033673negative regulation of kinase activity0.0256501195402001
GO:0051348negative regulation of transferase activity0.0256501195402001
GO:0043086negative regulation of catalytic activity0.0271862726864854
GO:0019887protein kinase regulator activity0.0318720337344778
GO:0019207kinase regulator activity0.0332672814824209
GO:0045859regulation of protein kinase activity0.0454415183000368
GO:0043549regulation of kinase activity0.0454415183000368
GO:0051338regulation of transferase activity0.0454415183000368



Relative expression of the co-expression cluster over median <br>Analyst:





Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
regional part of nervous system3.45e-1254
neurectoderm1.59e-1164
neural plate1.59e-1164
presumptive neural plate1.59e-1164
ecto-epithelium3.01e-1173
neural tube3.62e-1152
neural rod3.62e-1152
future spinal cord3.62e-1152
neural keel3.62e-1152
brain2.13e-0947
future brain2.13e-0947
ectoderm-derived structure3.36e-0995
ectoderm3.36e-0995
presumptive ectoderm3.36e-0995
pre-chordal neural plate4.20e-0949
regional part of brain7.41e-0946
central nervous system3.30e-0873
nervous system3.34e-0875
gray matter5.48e-0834
anterior neural tube1.98e-0740
adult organism3.73e-0751
regional part of forebrain6.87e-0739
forebrain6.87e-0739
future forebrain6.87e-0739


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs




JASPAR motifs


Motifs-log10(p-value)

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