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Coexpression cluster:C1737

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Full id: C1737_argyrophil_merkel_neuroblastoma_gastrointestinal_carcinoid_smallcell_small



Phase1 CAGE Peaks

Hg19::chr15:38920201..38920211,+p@chr15:38920201..38920211
+
Hg19::chr16:67219436..67219445,-p@chr16:67219436..67219445
-
Hg19::chr17:61598180..61598190,+p@chr17:61598180..61598190
+
Hg19::chr5:50681985..50682031,+p2@ISL1
Hg19::chr5:50687141..50687154,+p@chr5:50687141..50687154
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
Merkel cell9.95e-072
Uber Anatomy
Ontology termp-valuen
adult organism1.16e-09115
regional part of nervous system3.50e-0994
nervous system3.50e-0994
neural tube3.93e-0957
neural rod3.93e-0957
future spinal cord3.93e-0957
neural keel3.93e-0957
regional part of brain1.11e-0859
brain1.20e-0869
future brain1.20e-0869
sex gland2.14e-0812
male reproductive gland2.14e-0812
medulla oblongata3.43e-083
myelencephalon3.43e-083
future myelencephalon3.43e-083
neurectoderm3.76e-0890
neural plate7.25e-0886
presumptive neural plate7.25e-0886
central nervous system2.12e-0782
segmental subdivision of hindbrain2.90e-0712
hindbrain2.90e-0712
presumptive hindbrain2.90e-0712
male organism6.33e-0722
male reproductive system6.33e-0722
prostate gland9.98e-0711
male accessory sex gland9.98e-0711
embryonic cloacal epithelium9.98e-0711
epithelium of hindgut9.98e-0711
urogenital sinus epithelium9.98e-0711
prostate bud9.98e-0711
prostate field9.98e-0711


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.