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Coexpression cluster:C1593

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Full id: C1593_anaplastic_NK_blood_Natural_CD8_Whole_adult



Phase1 CAGE Peaks

Hg19::chr10:72357594..72357605,-p4@PRF1
Hg19::chr10:72362487..72362507,-p2@PRF1
Hg19::chr10:72362665..72362683,-p5@PRF1
Hg19::chr19:51875523..51875549,-p@chr19:51875523..51875549
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Hg19::chr19:55417469..55417480,+p2@NCR1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0001906cell killing2.68685548807027e-05
GO:0006968cellular defense response0.000252485390717191
GO:0051801cytolysis of cells in other organism during symbiotic interaction0.000958744547581376
GO:0001907killing by symbiont of host cells0.000958744547581376
GO:0052331hemolysis by organism of red blood cells in other organism during symbiotic interaction0.000958744547581376
GO:0051817modification of morphology or physiology of other organism during symbiotic interaction0.000958744547581376
GO:0051715cytolysis of cells of another organism0.000958744547581376
GO:0052043modification by symbiont of host cellular component0.000958744547581376
GO:0006927transformed cell apoptosis0.000958744547581376
GO:0031640killing of cells of another organism0.000958744547581376
GO:0001897cytolysis by symbiont of host cells0.000958744547581376
GO:0052185modification of structure of other organism during symbiotic interaction0.000958744547581376
GO:0051818disruption of cells of other organism during symbiotic interaction0.000958744547581376
GO:0052332modification by organism of cell membrane in other organism during symbiotic interaction0.000958744547581376
GO:0051883killing of cells in other organism during symbiotic interaction0.000958744547581376
GO:0019836hemolysis by symbiont of host red blood cells0.000958744547581376
GO:0044003modification by symbiont of host morphology or physiology0.000958744547581376
GO:0052188modification of cellular component in other organism during symbiotic interaction0.000958744547581376
GO:0052111modification by symbiont of host structure0.000958744547581376
GO:0052025modification by symbiont of host cell membrane0.000958744547581376
GO:0044004disruption by symbiont of host cells0.000958744547581376
GO:0006926virus-infected cell apoptosis0.00122020237302143
GO:0006952defense response0.00146227471504837
GO:0042269regulation of natural killer cell mediated cytotoxicity0.00195732153961825
GO:0016514SWI/SNF complex0.00206483628486486
GO:0045471response to ethanol0.00206483628486486
GO:0001910regulation of leukocyte mediated cytotoxicity0.00230670741862533
GO:0031341regulation of cell killing0.00230670741862533
GO:0006915apoptosis0.00230670741862533
GO:0012501programmed cell death0.00230670741862533
GO:0042267natural killer cell mediated cytotoxicity0.00230670741862533
GO:0002228natural killer cell mediated immunity0.00230670741862533
GO:0016265death0.00239270756740181
GO:0008219cell death0.00239270756740181
GO:0009405pathogenesis0.00249236892117645
GO:0001909leukocyte mediated cytotoxicity0.00260949314776118
GO:0019835cytolysis0.00290159034559855
GO:0030101natural killer cell activation0.00317829321061253
GO:0051701interaction with host0.00378475306873572
GO:0048468cell development0.00380635062002154
GO:0007623circadian rhythm0.00474513809620455
GO:0044403symbiosis, encompassing mutualism through parasitism0.00499225835979043
GO:0044419interspecies interaction between organisms0.00499225835979043
GO:0016585chromatin remodeling complex0.00625013144668185
GO:0048869cellular developmental process0.00703128521102429
GO:0030154cell differentiation0.00703128521102429
GO:0010033response to organic substance0.00884539981063303
GO:0002449lymphocyte mediated immunity0.0100565938693465
GO:0002443leukocyte mediated immunity0.0106713602344203
GO:0002252immune effector process0.0147414128790072
GO:0045087innate immune response0.0149770229113583
GO:0046649lymphocyte activation0.0199598181369645
GO:0032502developmental process0.0208728226941865
GO:0005057receptor signaling protein activity0.0219067445981678
GO:0045321leukocyte activation0.0219067445981678
GO:0001775cell activation0.0245701659673497
GO:0006917induction of apoptosis0.0245701659673497
GO:0012502induction of programmed cell death0.0245701659673497
GO:0043065positive regulation of apoptosis0.0287498970203366
GO:0043068positive regulation of programmed cell death0.0287498970203366
GO:0051704multi-organism process0.0364586630602866
GO:0016023cytoplasmic membrane-bound vesicle0.0373049438326
GO:0031988membrane-bound vesicle0.0373049438326
GO:0031410cytoplasmic vesicle0.044289821495002
GO:0031982vesicle0.0443221006614301
GO:0044451nucleoplasm part0.0456578825829426



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
hematopoietic stem cell2.19e-31172
angioblastic mesenchymal cell2.19e-31172
hematopoietic cell5.33e-31182
hematopoietic oligopotent progenitor cell4.39e-30165
hematopoietic multipotent progenitor cell4.39e-30165
leukocyte1.11e-24140
nongranular leukocyte5.86e-21119
hematopoietic lineage restricted progenitor cell7.71e-20124
T cell1.95e-1925
pro-T cell1.95e-1925
lymphoid lineage restricted progenitor cell4.04e-1852
lymphocyte1.83e-1753
common lymphoid progenitor1.83e-1753
mature alpha-beta T cell1.20e-1518
alpha-beta T cell1.20e-1518
immature T cell1.20e-1518
mature T cell1.20e-1518
immature alpha-beta T cell1.20e-1518
myeloid cell1.75e-13112
common myeloid progenitor1.75e-13112
CD8-positive, alpha-beta T cell1.70e-1111
myeloid leukocyte4.47e-0876
CD14-positive, CD16-negative classical monocyte6.91e-0842
classical monocyte8.87e-0745
Uber Anatomy
Ontology termp-valuen
adult organism1.57e-28115
blood3.01e-1415
haemolymphatic fluid3.01e-1415
organism substance3.01e-1415
hematopoietic system1.17e-12102
blood island1.17e-12102
hemolymphoid system1.25e-11112
Disease
Ontology termp-valuen
leukemia7.93e-0939
hematologic cancer1.46e-0751
immune system cancer1.46e-0751
myeloid leukemia5.86e-0731


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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