Coexpression cluster:C1593

Full id: C1593_anaplastic_NK_blood_Natural_CD8_Whole_adult

Phase1 CAGE Peaks

Hg19::chr10:72357594..72357605,-	p4@PRF1
Hg19::chr10:72362487..72362507,-	p2@PRF1
Hg19::chr10:72362665..72362683,-	p5@PRF1
Hg19::chr19:51875523..51875549,-	p@chr19:51875523..51875549 -
Hg19::chr19:55417469..55417480,+	p2@NCR1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

p.value	FDR	nGenes	nPathway	Name
2.28656823893637e-05	0.0144739769524672	2	137	Natural killer cell mediated cytotoxicity (KEGG):04650

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0001906	cell killing	2.68685548807027e-05
GO:0006968	cellular defense response	0.000252485390717191
GO:0051801	cytolysis of cells in other organism during symbiotic interaction	0.000958744547581376
GO:0001907	killing by symbiont of host cells	0.000958744547581376
GO:0052331	hemolysis by organism of red blood cells in other organism during symbiotic interaction	0.000958744547581376
GO:0051817	modification of morphology or physiology of other organism during symbiotic interaction	0.000958744547581376
GO:0051715	cytolysis of cells of another organism	0.000958744547581376
GO:0052043	modification by symbiont of host cellular component	0.000958744547581376
GO:0006927	transformed cell apoptosis	0.000958744547581376
GO:0031640	killing of cells of another organism	0.000958744547581376
GO:0001897	cytolysis by symbiont of host cells	0.000958744547581376
GO:0052185	modification of structure of other organism during symbiotic interaction	0.000958744547581376
GO:0051818	disruption of cells of other organism during symbiotic interaction	0.000958744547581376
GO:0052332	modification by organism of cell membrane in other organism during symbiotic interaction	0.000958744547581376
GO:0051883	killing of cells in other organism during symbiotic interaction	0.000958744547581376
GO:0019836	hemolysis by symbiont of host red blood cells	0.000958744547581376
GO:0044003	modification by symbiont of host morphology or physiology	0.000958744547581376
GO:0052188	modification of cellular component in other organism during symbiotic interaction	0.000958744547581376
GO:0052111	modification by symbiont of host structure	0.000958744547581376
GO:0052025	modification by symbiont of host cell membrane	0.000958744547581376
GO:0044004	disruption by symbiont of host cells	0.000958744547581376
GO:0006926	virus-infected cell apoptosis	0.00122020237302143
GO:0006952	defense response	0.00146227471504837
GO:0042269	regulation of natural killer cell mediated cytotoxicity	0.00195732153961825
GO:0016514	SWI/SNF complex	0.00206483628486486
GO:0045471	response to ethanol	0.00206483628486486
GO:0001910	regulation of leukocyte mediated cytotoxicity	0.00230670741862533
GO:0031341	regulation of cell killing	0.00230670741862533
GO:0006915	apoptosis	0.00230670741862533
GO:0012501	programmed cell death	0.00230670741862533
GO:0042267	natural killer cell mediated cytotoxicity	0.00230670741862533
GO:0002228	natural killer cell mediated immunity	0.00230670741862533
GO:0016265	death	0.00239270756740181
GO:0008219	cell death	0.00239270756740181
GO:0009405	pathogenesis	0.00249236892117645
GO:0001909	leukocyte mediated cytotoxicity	0.00260949314776118
GO:0019835	cytolysis	0.00290159034559855
GO:0030101	natural killer cell activation	0.00317829321061253
GO:0051701	interaction with host	0.00378475306873572
GO:0048468	cell development	0.00380635062002154
GO:0007623	circadian rhythm	0.00474513809620455
GO:0044403	symbiosis, encompassing mutualism through parasitism	0.00499225835979043
GO:0044419	interspecies interaction between organisms	0.00499225835979043
GO:0016585	chromatin remodeling complex	0.00625013144668185
GO:0048869	cellular developmental process	0.00703128521102429
GO:0030154	cell differentiation	0.00703128521102429
GO:0010033	response to organic substance	0.00884539981063303
GO:0002449	lymphocyte mediated immunity	0.0100565938693465
GO:0002443	leukocyte mediated immunity	0.0106713602344203
GO:0002252	immune effector process	0.0147414128790072
GO:0045087	innate immune response	0.0149770229113583
GO:0046649	lymphocyte activation	0.0199598181369645
GO:0032502	developmental process	0.0208728226941865
GO:0005057	receptor signaling protein activity	0.0219067445981678
GO:0045321	leukocyte activation	0.0219067445981678
GO:0001775	cell activation	0.0245701659673497
GO:0006917	induction of apoptosis	0.0245701659673497
GO:0012502	induction of programmed cell death	0.0245701659673497
GO:0043065	positive regulation of apoptosis	0.0287498970203366
GO:0043068	positive regulation of programmed cell death	0.0287498970203366
GO:0051704	multi-organism process	0.0364586630602866
GO:0016023	cytoplasmic membrane-bound vesicle	0.0373049438326
GO:0031988	membrane-bound vesicle	0.0373049438326
GO:0031410	cytoplasmic vesicle	0.044289821495002
GO:0031982	vesicle	0.0443221006614301
GO:0044451	nucleoplasm part	0.0456578825829426

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

---

Cell Type

Ontology term	p-value	n
hematopoietic stem cell	2.19e-31	172
angioblastic mesenchymal cell	2.19e-31	172
hematopoietic cell	5.33e-31	182
hematopoietic oligopotent progenitor cell	4.39e-30	165
hematopoietic multipotent progenitor cell	4.39e-30	165
leukocyte	1.11e-24	140
nongranular leukocyte	5.86e-21	119
hematopoietic lineage restricted progenitor cell	7.71e-20	124
T cell	1.95e-19	25
pro-T cell	1.95e-19	25
lymphoid lineage restricted progenitor cell	4.04e-18	52
lymphocyte	1.83e-17	53
common lymphoid progenitor	1.83e-17	53
mature alpha-beta T cell	1.20e-15	18
alpha-beta T cell	1.20e-15	18
immature T cell	1.20e-15	18
mature T cell	1.20e-15	18
immature alpha-beta T cell	1.20e-15	18
myeloid cell	1.75e-13	112
common myeloid progenitor	1.75e-13	112
CD8-positive, alpha-beta T cell	1.70e-11	11
myeloid leukocyte	4.47e-08	76
CD14-positive, CD16-negative classical monocyte	6.91e-08	42
classical monocyte	8.87e-07	45

Uber Anatomy

Ontology term	p-value	n
adult organism	1.57e-28	115
blood	3.01e-14	15
haemolymphatic fluid	3.01e-14	15
organism substance	3.01e-14	15
hematopoietic system	1.17e-12	102
blood island	1.17e-12	102
hemolymphoid system	1.25e-11	112

Disease

Ontology term	p-value	n
leukemia	7.93e-09	39
hematologic cancer	1.46e-07	51
immune system cancer	1.46e-07	51
myeloid leukemia	5.86e-07	31

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

This analysis result is provided for C0 - C305 clusters.