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Coexpression cluster:C3331

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Full id: C3331_brain_occipital_paracentral_parietal_insula_postcentral_pons



Phase1 CAGE Peaks

Hg19::chr12:75603643..75603652,-p19@KCNC2
Hg19::chr1:116915494..116915499,+p52@ATP1A1
Hg19::chr7:152456920..152456929,+p4@ACTR3B


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0030955potassium ion binding0.00539806025887904
GO:0031420alkali metal ion binding0.00585347486191332
GO:0006813potassium ion transport0.00585347486191332
GO:0005890sodium:potassium-exchanging ATPase complex0.0148899497119923
GO:0015672monovalent inorganic cation transport0.0148899497119923
GO:0030641cellular hydrogen ion homeostasis0.0153004158396385
GO:0030001metal ion transport0.0153004158396385
GO:0055067monovalent inorganic cation homeostasis0.0153004158396385
GO:0030004cellular monovalent inorganic cation homeostasis0.0153004158396385
GO:0005391sodium:potassium-exchanging ATPase activity0.01548990470091
GO:0030317sperm motility0.01548990470091
GO:0006812cation transport0.01548990470091
GO:0008324cation transmembrane transporter activity0.01548990470091
GO:0015075ion transmembrane transporter activity0.0287753110400164
GO:0005887integral to plasma membrane0.0287753110400164
GO:0031226intrinsic to plasma membrane0.0287753110400164
GO:0006811ion transport0.0287753110400164
GO:0022891substrate-specific transmembrane transporter activity0.0336885223102745
GO:0022857transmembrane transporter activity0.0362112514340256
GO:0048770pigment granule0.0362112514340256
GO:0042470melanosome0.0362112514340256
GO:0022892substrate-specific transporter activity0.0369774297685521
GO:0031402sodium ion binding0.0382262584592676
GO:0008076voltage-gated potassium channel complex0.0468993386301315



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
central nervous system4.42e-2282
regional part of nervous system1.06e-2194
nervous system1.06e-2194
neural tube1.23e-2157
neural rod1.23e-2157
future spinal cord1.23e-2157
neural keel1.23e-2157
brain9.74e-2169
future brain9.74e-2169
regional part of brain6.33e-1959
telencephalon8.43e-1934
cerebral hemisphere9.34e-1932
regional part of forebrain1.01e-1841
forebrain1.01e-1841
future forebrain1.01e-1841
gray matter1.82e-1834
brain grey matter1.82e-1834
anterior neural tube4.83e-1842
regional part of telencephalon1.10e-1733
neural plate4.33e-1686
presumptive neural plate4.33e-1686
neurectoderm1.32e-1590
cerebral cortex1.32e-1525
pallium1.32e-1525
regional part of cerebral cortex1.38e-1422
neocortex1.74e-1420
pre-chordal neural plate5.21e-1361
adult organism1.48e-11115
head5.36e-11123
anterior region of body2.56e-10129
craniocervical region2.56e-10129
ectoderm-derived structure1.86e-09169
ectoderm2.30e-09173
presumptive ectoderm2.30e-09173
occipital lobe1.50e-075


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.