MCL coexpression mm9:1893

Phase1 CAGE Peaks

	Short description
Mm9::chr10:57351852..57351866,+	p3@Pkib
Mm9::chr10:57351868..57351907,+	p1@Pkib
Mm9::chr10:57351914..57351926,+	p5@Pkib
Mm9::chr12:99813245..99813258,-	p6@Kcnk10

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004862	cAMP-dependent protein kinase inhibitor activity	0.0121617179066112
GO:0004860	protein kinase inhibitor activity	0.0256501195402001
GO:0019210	kinase inhibitor activity	0.0256501195402001
GO:0006469	negative regulation of protein kinase activity	0.0256501195402001
GO:0033673	negative regulation of kinase activity	0.0256501195402001
GO:0051348	negative regulation of transferase activity	0.0256501195402001
GO:0043086	negative regulation of catalytic activity	0.0271862726864854
GO:0019887	protein kinase regulator activity	0.0318720337344778
GO:0019207	kinase regulator activity	0.0332672814824209
GO:0045859	regulation of protein kinase activity	0.0454415183000368
GO:0043549	regulation of kinase activity	0.0454415183000368
GO:0051338	regulation of transferase activity	0.0454415183000368

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	3.45e-12	54
neurectoderm	1.59e-11	64
neural plate	1.59e-11	64
presumptive neural plate	1.59e-11	64
ecto-epithelium	3.01e-11	73
neural tube	3.62e-11	52
neural rod	3.62e-11	52
future spinal cord	3.62e-11	52
neural keel	3.62e-11	52
brain	2.13e-09	47
future brain	2.13e-09	47
ectoderm-derived structure	3.36e-09	95
ectoderm	3.36e-09	95
presumptive ectoderm	3.36e-09	95
pre-chordal neural plate	4.20e-09	49
regional part of brain	7.41e-09	46
central nervous system	3.30e-08	73
nervous system	3.34e-08	75
gray matter	5.48e-08	34
anterior neural tube	1.98e-07	40
adult organism	3.73e-07	51
regional part of forebrain	6.87e-07	39
forebrain	6.87e-07	39
future forebrain	6.87e-07	39

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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