MCL coexpression mm9:2690

Phase1 CAGE Peaks

	Short description
Mm9::chr11:58762392..58762422,+	p1@Hist3h2ba p1@Hist3h2bb-ps
Mm9::chr19:18787682..18787702,+	p2@D030056L22Rik
Mm9::chr8:87493555..87493578,+	p2@Prdx2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008379	thioredoxin peroxidase activity	0.00734125897112804
GO:0051920	peroxiredoxin activity	0.0220207602882316
GO:0006800	oxygen and reactive oxygen species metabolic process	0.0403415292727481
GO:0008430	selenium binding	0.0403415292727481
GO:0004601	peroxidase activity	0.0403415292727481
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	0.0403415292727481
GO:0006979	response to oxidative stress	0.0471369227400901

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
neuron	6.80e-16	33
neuronal stem cell	6.80e-16	33
neuroblast	6.80e-16	33
electrically signaling cell	6.80e-16	33
ectodermal cell	1.84e-15	44
neurectodermal cell	1.84e-15	44
neural cell	6.79e-15	43
CNS neuron (sensu Vertebrata)	1.98e-14	23
neuroblast (sensu Vertebrata)	1.98e-14	23
electrically responsive cell	1.79e-11	39
electrically active cell	1.79e-11	39
non-terminally differentiated cell	2.68e-11	49

Uber Anatomy

Ontology term	p-value	n
central nervous system	4.30e-23	73
nervous system	5.80e-22	75
neurectoderm	1.09e-19	64
neural plate	1.09e-19	64
presumptive neural plate	1.09e-19	64
ectoderm-derived structure	1.64e-18	95
ectoderm	1.64e-18	95
presumptive ectoderm	1.64e-18	95
regional part of nervous system	1.09e-17	54
neural tube	5.20e-16	52
neural rod	5.20e-16	52
future spinal cord	5.20e-16	52
neural keel	5.20e-16	52
ecto-epithelium	5.60e-16	73
pre-chordal neural plate	1.13e-15	49
gray matter	1.34e-14	34
structure with developmental contribution from neural crest	4.05e-14	92
brain	6.50e-14	47
future brain	6.50e-14	47
regional part of brain	1.26e-13	46
anterior neural tube	3.94e-13	40
regional part of forebrain	5.47e-13	39
forebrain	5.47e-13	39
future forebrain	5.47e-13	39
brain grey matter	6.87e-12	29
regional part of telencephalon	6.87e-12	29
telencephalon	6.87e-12	29
cerebral cortex	1.71e-08	21
cerebral hemisphere	1.71e-08	21
pallium	1.71e-08	21

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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