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Coexpression cluster:C1105

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Full id: C1105_CD14_CD19_acute_CD14CD16_CD4_Mast_granulocyte



Phase1 CAGE Peaks

Hg19::chr10:114134954..114135003,+p5@ACSL5
Hg19::chr10:114135952..114136022,+p1@ACSL5
Hg19::chr15:81293457..81293493,+p3@MESDC1
Hg19::chr19:14247942..14248026,+p1@LOC100507373
Hg19::chr19:54876447..54876469,-p3@LAIR1
Hg19::chr19:54876483..54876501,-p2@LAIR1
Hg19::chr1:209941862..209941887,+p6@TRAF3IP3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0004467long-chain-fatty-acid-CoA ligase activity0.0269268105022804
GO:0015645fatty-acid ligase activity0.0269268105022804
GO:0016877ligase activity, forming carbon-sulfur bonds0.0361194873165629
GO:0031903microbody membrane0.0361194873165629
GO:0005778peroxisomal membrane0.0361194873165629
GO:0044439peroxisomal part0.0361194873165629
GO:0044438microbody part0.0361194873165629
GO:0005741mitochondrial outer membrane0.0383650411735975
GO:0016021integral to membrane0.0383650411735975
GO:0031224intrinsic to membrane0.0383650411735975
GO:0031968organelle outer membrane0.0383650411735975
GO:0019867outer membrane0.0383650411735975
GO:0042579microbody0.0383650411735975
GO:0005777peroxisome0.0383650411735975
GO:0044425membrane part0.0478199413750389



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell2.63e-67172
angioblastic mesenchymal cell2.63e-67172
hematopoietic oligopotent progenitor cell1.33e-63165
hematopoietic multipotent progenitor cell1.33e-63165
hematopoietic cell5.53e-63182
leukocyte3.82e-61140
hematopoietic lineage restricted progenitor cell5.72e-55124
nongranular leukocyte1.27e-53119
myeloid cell1.36e-39112
common myeloid progenitor1.36e-39112
myeloid leukocyte1.38e-3576
granulocyte monocyte progenitor cell2.06e-3371
myeloid lineage restricted progenitor cell8.04e-3370
macrophage dendritic cell progenitor2.25e-3065
monopoietic cell3.75e-3063
monocyte3.75e-3063
monoblast3.75e-3063
promonocyte3.75e-3063
CD14-positive, CD16-negative classical monocyte3.59e-2742
classical monocyte3.98e-2645
lymphocyte1.93e-2053
common lymphoid progenitor1.93e-2053
lymphoid lineage restricted progenitor cell3.76e-2052
mesenchymal cell1.35e-15358
connective tissue cell5.01e-14365
T cell1.42e-1025
pro-T cell1.42e-1025
lymphocyte of B lineage1.57e-0924
pro-B cell1.57e-0924
mature alpha-beta T cell3.10e-0918
alpha-beta T cell3.10e-0918
immature T cell3.10e-0918
mature T cell3.10e-0918
immature alpha-beta T cell3.10e-0918
motile cell5.64e-09390
B cell7.85e-0814
intermediate monocyte8.05e-079
CD14-positive, CD16-positive monocyte8.05e-079
Uber Anatomy
Ontology termp-valuen
hemolymphoid system1.83e-38112
hematopoietic system7.32e-38102
blood island7.32e-38102
bone marrow2.83e-2980
immune system9.27e-28115
bone element1.47e-2486
adult organism1.43e-18115
skeletal element1.98e-16101
skeletal system1.98e-16101
lateral plate mesoderm4.97e-13216
connective tissue1.10e-12375
Disease
Ontology termp-valuen
hematologic cancer2.82e-0951
immune system cancer2.82e-0951
leukemia7.08e-0839


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.