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Coexpression cluster:C1214

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Full id: C1214_Eosinophils_Natural_CD14_Basophils_Neutrophils_Mast_CD34



Phase1 CAGE Peaks

Hg19::chr15:94850232..94850237,+p@chr15:94850232..94850237
+
Hg19::chr19:13957417..13957455,-p@chr19:13957417..13957455
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Hg19::chr19:13973090..13973103,-p@chr19:13973090..13973103
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Hg19::chr19:39894772..39894785,+p@chr19:39894772..39894785
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Hg19::chr20:35233898..35233903,-p@chr20:35233898..35233903
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Hg19::chr2:137000368..137000372,-p@chr2:137000368..137000372
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Hg19::chr2:28582698..28582710,+p@chr2:28582698..28582710
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
classical monocyte7.69e-9242
CD14-positive, CD16-negative classical monocyte7.69e-9242
defensive cell9.33e-7948
phagocyte9.33e-7948
myeloid leukocyte8.60e-7872
leukocyte1.98e-73136
granulocyte monocyte progenitor cell2.48e-6367
myeloid lineage restricted progenitor cell1.32e-6166
macrophage dendritic cell progenitor5.43e-6161
monopoietic cell1.86e-6059
monocyte1.86e-6059
monoblast1.86e-6059
promonocyte1.86e-6059
hematopoietic stem cell7.36e-60168
angioblastic mesenchymal cell7.36e-60168
nongranular leukocyte4.13e-58115
hematopoietic lineage restricted progenitor cell2.95e-57120
hematopoietic cell6.69e-56177
hematopoietic oligopotent progenitor cell2.30e-53161
hematopoietic multipotent progenitor cell2.30e-53161
myeloid cell3.77e-51108
common myeloid progenitor3.77e-51108
stuff accumulating cell8.36e-3887
mesenchymal cell1.39e-20354
intermediate monocyte7.16e-209
CD14-positive, CD16-positive monocyte7.16e-209
connective tissue cell7.90e-20361
motile cell3.57e-17386
granulocyte4.44e-158
multi fate stem cell6.12e-14427
stem cell1.32e-13441
somatic stem cell1.71e-13433
blood cell1.30e-1011
natural killer cell5.79e-093
pro-NK cell5.79e-093
basophil1.87e-083
single nucleate cell1.90e-073
mononuclear cell1.90e-073
mature alpha-beta T cell4.32e-0718
alpha-beta T cell4.32e-0718
immature T cell4.32e-0718
mature T cell4.32e-0718
immature alpha-beta T cell4.32e-0718
non-classical monocyte4.75e-073
CD14-low, CD16-positive monocyte4.75e-073
Uber Anatomy
Ontology termp-valuen
bone marrow4.76e-5776
bone element6.30e-5282
hematopoietic system1.15e-4798
blood island1.15e-4798
skeletal element3.73e-4690
immune system3.02e-4493
hemolymphoid system5.57e-42108
skeletal system3.10e-40100
musculoskeletal system6.20e-19167
connective tissue8.44e-19371
lateral plate mesoderm6.43e-17203
mesoderm1.87e-07315
mesoderm-derived structure1.87e-07315
presumptive mesoderm1.87e-07315


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#53335312.15833790154590.001376980163459870.00897077108674352
BCL3#602314.80590120160210.0007772745735585960.00609076974699026
CCNT2#90554.525858269259020.00155157330626470.00985613798023105
EP300#203343.870823843556110.01142567586684480.0418608770735073
FOS#235345.141688747939660.004042095865678250.019348815203757
FOSL2#235537.255800259097870.006020775093849750.0269861263476492
HMGN3#932444.673455841914620.005751881099938870.0259098861417518
JUN#372547.150188109906480.001171328177707770.00795864573232855
JUNB#3726313.11884256849480.00110478999316960.00767838970497372
MEF2C#4208211.80324414074970.01134538181234960.0416002644068385
NFKB1#479053.92004530299560.003036581424484610.0161196262779174
PAX5#507954.763975379412740.001218821047007470.00820077640306745
POU2F2#545245.203499461567160.003866714310179810.0190659447543019
SP1#666754.070272412957780.002549206128991580.0141112280121774
SPI1#668844.688184862012990.005685680529144170.0256670321496991
SRF#672235.913076398071920.01066868130167450.0393942301819257
TCF12#693857.596046358704590.0001311126373938080.00172459354367404
TCF7L2#693446.154386607507050.002064676148138040.01197227873163
ZEB1#693537.237899436090220.00606280792035710.02683364819232



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.