Coexpression cluster:C145

Full id: C145_neuroblastoma_peripheral_neuroectodermal_neuroepithelioma_carcinoid_adult_extraskeletal

Phase1 CAGE Peaks

Hg19::chr10:115469134..115469144,+	p11@CASP7
Hg19::chr10:130493765..130493772,+	p@chr10:130493765..130493772 +
Hg19::chr10:19206477..19206486,-	p@chr10:19206477..19206486 -
Hg19::chr11:111061427..111061435,-	p@chr11:111061427..111061435 -
Hg19::chr11:126898086..126898090,-	p@chr11:126898086..126898090 -
Hg19::chr12:20097309..20097312,+	p@chr12:20097309..20097312 +
Hg19::chr13:19866903..19866909,-	p@chr13:19866903..19866909 -
Hg19::chr13:19866912..19866922,-	p@chr13:19866912..19866922 -
Hg19::chr13:19867186..19867230,-	p@chr13:19867186..19867230 -
Hg19::chr13:21817233..21817255,+	p@chr13:21817233..21817255 +
Hg19::chr13:31573586..31573598,-	p@chr13:31573586..31573598 -
Hg19::chr13:31576161..31576165,-	p@chr13:31576161..31576165 -
Hg19::chr13:31586634..31586639,-	p@chr13:31586634..31586639 -
Hg19::chr13:31590717..31590730,-	p@chr13:31590717..31590730 -
Hg19::chr13:98503553..98503558,-	p@chr13:98503553..98503558 -
Hg19::chr14:96944793..96944803,+	p@chr14:96944793..96944803 +
Hg19::chr15:101818299..101818304,-	p@chr15:101818299..101818304 -
Hg19::chr15:70867778..70867780,-	p@chr15:70867778..70867780 -
Hg19::chr16:57880370..57880384,-	p8@KIFC3
Hg19::chr16:8626896..8626903,+	p@chr16:8626896..8626903 +
Hg19::chr16:8626925..8626935,+	p@chr16:8626925..8626935 +
Hg19::chr16:8626942..8626951,+	p@chr16:8626942..8626951 +
Hg19::chr16:8626961..8626972,+	p@chr16:8626961..8626972 +
Hg19::chr16:8627043..8627056,+	p@chr16:8627043..8627056 +
Hg19::chr16:8627138..8627146,+	p@chr16:8627138..8627146 +
Hg19::chr18:3742467..3742480,-	p19@DLGAP1
Hg19::chr18:56886837..56886844,+	p@chr18:56886837..56886844 +
Hg19::chr18:56886851..56886854,+	p@chr18:56886851..56886854 +
Hg19::chr18:56892776..56892782,+	p6@GRP
Hg19::chr18:77044132..77044175,+	p@chr18:77044132..77044175 +
Hg19::chr1:12710326..12710358,+	p@chr1:12710326..12710358 +
Hg19::chr1:177701516..177701535,-	p@chr1:177701516..177701535 -
Hg19::chr1:201328857..201328867,-	p@chr1:201328857..201328867 -
Hg19::chr1:209796957..209796972,-	p4@MIR4260
Hg19::chr1:209796983..209796993,-	p6@MIR4260
Hg19::chr1:209797028..209797042,-	p3@MIR4260
Hg19::chr1:209797044..209797052,-	p7@MIR4260
Hg19::chr1:209797057..209797070,-	p5@MIR4260
Hg19::chr1:209798010..209798013,-	p@chr1:209798010..209798013 -
Hg19::chr1:209798058..209798063,-	p@chr1:209798058..209798063 -
Hg19::chr1:236451669..236451673,+	p@chr1:236451669..236451673 +
Hg19::chr1:236818586..236818597,+	p@chr1:236818586..236818597 +
Hg19::chr1:247615972..247615977,-	p@chr1:247615972..247615977 -
Hg19::chr1:39045718..39045723,-	p@chr1:39045718..39045723 -
Hg19::chr1:60324644..60324660,+	p@chr1:60324644..60324660 +
Hg19::chr1:72475310..72475318,+	p@chr1:72475310..72475318 +
Hg19::chr20:24607850..24607857,-	p@chr20:24607850..24607857 -
Hg19::chr20:24608066..24608086,-	p@chr20:24608066..24608086 -
Hg19::chr20:24608551..24608564,-	p@chr20:24608551..24608564 -
Hg19::chr20:24608570..24608595,-	p@chr20:24608570..24608595 -
Hg19::chr20:24608639..24608641,-	p@chr20:24608639..24608641 -
Hg19::chr20:49393105..49393130,+	p@chr20:49393105..49393130 +
Hg19::chr21:27922896..27922913,+	p@chr21:27922896..27922913 +
Hg19::chr21:27924233..27924255,+	p@chr21:27924233..27924255 +
Hg19::chr21:27924313..27924341,+	p@chr21:27924313..27924341 +
Hg19::chr21:27941000..27941004,+	p@chr21:27941000..27941004 +
Hg19::chr21:28022135..28022171,+	p@chr21:28022135..28022171 +
Hg19::chr21:28025780..28025786,+	p@chr21:28025780..28025786 +
Hg19::chr21:28083005..28083006,+	p@chr21:28083005..28083006 +
Hg19::chr21:46341022..46341041,+	p2@ENST00000441379 p2@uc002zgh.2
Hg19::chr2:121797299..121797304,+	p@chr2:121797299..121797304 +
Hg19::chr2:152185906..152185915,-	p@chr2:152185906..152185915 -
Hg19::chr2:152185920..152185940,-	p@chr2:152185920..152185940 -
Hg19::chr2:152185966..152185977,-	p@chr2:152185966..152185977 -
Hg19::chr2:152186077..152186088,-	p@chr2:152186077..152186088 -
Hg19::chr2:152186116..152186128,-	p@chr2:152186116..152186128 -
Hg19::chr2:152186130..152186137,-	p@chr2:152186130..152186137 -
Hg19::chr2:178013069..178013115,-	p@chr2:178013069..178013115 -
Hg19::chr2:208528667..208528672,+	p@chr2:208528667..208528672 +
Hg19::chr2:234265736..234265757,+	p@chr2:234265736..234265757 +
Hg19::chr2:234265804..234265830,+	p@chr2:234265804..234265830 +
Hg19::chr2:234699417..234699436,+	p@chr2:234699417..234699436 +
Hg19::chr2:234699439..234699454,+	p@chr2:234699439..234699454 +
Hg19::chr2:234699458..234699476,+	p@chr2:234699458..234699476 +
Hg19::chr2:234699501..234699508,+	p@chr2:234699501..234699508 +
Hg19::chr2:234699525..234699537,+	p@chr2:234699525..234699537 +
Hg19::chr2:234699597..234699619,+	p@chr2:234699597..234699619 +
Hg19::chr3:126191239..126191272,-	p11@ZXDC
Hg19::chr3:197808599..197808629,-	p@chr3:197808599..197808629 -
Hg19::chr3:197836976..197836989,+	p1@ENST00000419104 p1@ENST00000422555
Hg19::chr3:58223326..58223335,+	p5@ABHD6
Hg19::chr4:159766833..159766839,-	p@chr4:159766833..159766839 -
Hg19::chr4:166503334..166503340,+	p@chr4:166503334..166503340 +
Hg19::chr4:41750793..41750804,-	p5@PHOX2B
Hg19::chr4:72897707..72897731,+	p1@NPFFR2
Hg19::chr4:72897735..72897749,+	p3@NPFFR2
Hg19::chr4:72897772..72897779,+	p6@NPFFR2
Hg19::chr4:72897784..72897795,+	p2@NPFFR2
Hg19::chr4:72897809..72897820,+	p4@NPFFR2
Hg19::chr5:124007135..124007142,+	p@chr5:124007135..124007142 +
Hg19::chr5:42970980..42970988,+	p@chr5:42970980..42970988 +
Hg19::chr5:43033953..43033958,+	p@chr5:43033953..43033958 +
Hg19::chr6:123160336..123160346,+	p@chr6:123160336..123160346 +
Hg19::chr6:123160905..123160921,+	p@chr6:123160905..123160921 +
Hg19::chr6:123160933..123160937,+	p@chr6:123160933..123160937 +
Hg19::chr6:123194886..123194889,+	p@chr6:123194886..123194889 +
Hg19::chr6:14537245..14537253,-	p@chr6:14537245..14537253 -
Hg19::chr6:16804682..16804686,+	p@chr6:16804682..16804686 +
Hg19::chr6:3939499..3939502,-	p@chr6:3939499..3939502 -
Hg19::chr6:83931577..83931579,+	p@chr6:83931577..83931579 +
Hg19::chr7:31232388..31232398,-	p@chr7:31232388..31232398 -
Hg19::chr7:41976787..41976795,+	p@chr7:41976787..41976795 +
Hg19::chr7:7553032..7553040,+	p@chr7:7553032..7553040 +
Hg19::chr8:2072348..2072354,-	p@chr8:2072348..2072354 -
Hg19::chr8:26723933..26723943,-	p@chr8:26723933..26723943 -
Hg19::chr8:27041862..27041872,+	p1@ENST00000521408
Hg19::chr8:28174496..28174516,+	p3@PNOC
Hg19::chr8:28200458..28200480,+	p@chr8:28200458..28200480 +
Hg19::chr8:37560262..37560269,-	p@chr8:37560262..37560269 -
Hg19::chr8:70745541..70745555,-	p3@SLCO5A1
Hg19::chr8:97136855..97136857,-	p@chr8:97136855..97136857 -
Hg19::chr8:97173993..97174018,-	p@chr8:97173993..97174018 -
Hg19::chr8:97174234..97174264,-	p@chr8:97174234..97174264 -
Hg19::chr8:97178060..97178066,+	p@chr8:97178060..97178066 +
Hg19::chr9:90112117..90112164,+	p19@DAPK1
Hg19::chrX:135918268..135918276,+	p@chrX:135918268..135918276 +
Hg19::chrX:25034686..25034690,-	p@chrX:25034686..25034690 -
Hg19::chrX:2712069..2712080,+	p6@XG

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005184	neuropeptide hormone activity	0.0115249039428662

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

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Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	7.58e-20	94
nervous system	7.58e-20	94
central nervous system	1.11e-18	82
cerebral hemisphere	2.07e-14	32
gray matter	2.45e-14	34
brain grey matter	2.45e-14	34
brain	4.44e-14	69
future brain	4.44e-14	69
neural tube	6.38e-14	57
neural rod	6.38e-14	57
future spinal cord	6.38e-14	57
neural keel	6.38e-14	57
cerebral cortex	7.49e-14	25
pallium	7.49e-14	25
telencephalon	7.81e-14	34
ectoderm	1.01e-13	173
presumptive ectoderm	1.01e-13	173
regional part of cerebral cortex	2.39e-13	22
neurectoderm	2.44e-13	90
regional part of forebrain	2.49e-13	41
forebrain	2.49e-13	41
future forebrain	2.49e-13	41
regional part of telencephalon	2.97e-13	33
anterior neural tube	2.28e-12	42
neocortex	3.08e-12	20
regional part of brain	3.39e-12	59
ectoderm-derived structure	4.31e-12	169
neural plate	2.09e-11	86
presumptive neural plate	2.09e-11	86
pre-chordal neural plate	2.99e-10	61
organ part	1.14e-08	219
anterior region of body	7.58e-08	129
craniocervical region	7.58e-08	129
head	2.99e-07	123
adult organism	6.71e-07	115

Disease

Ontology term	p-value	n
germ cell and embryonal cancer	6.85e-09	22
germ cell cancer	6.85e-09	22
cancer	5.19e-07	235
cell type cancer	8.04e-07	143

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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