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Coexpression cluster:C2236

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Full id: C2236_Eosinophils_Neutrophils_CD14CD16_CD14_Mast_Whole_CD19



Phase1 CAGE Peaks

Hg19::chr12:7060508..7060609,+p1@PTPN6
Hg19::chr12:7060615..7060624,+p8@PTPN6
Hg19::chr19:41848208..41848225,-p18@TGFB1
Hg19::chr5:55711409..55711446,+p@chr5:55711409..55711446
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


p.valueFDRnGenesnPathwayName
6.45030198789693e-060.00408304115833875273Leishmaniasis (KEGG):05140



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0006470protein amino acid dephosphorylation0.00206049010094955
GO:0045066regulatory T cell differentiation0.00206049010094955
GO:0051280negative regulation of release of sequestered calcium ion into cytosol0.00206049010094955
GO:0009814defense response, incompatible interaction0.00206049010094955
GO:0009817defense response to fungus, incompatible interaction0.00206049010094955
GO:0050765negative regulation of phagocytosis0.00206049010094955
GO:0016311dephosphorylation0.00206049010094955
GO:0019049evasion of host defenses by virus0.00206049010094955
GO:0044415evasion or tolerance of host defenses0.00206049010094955
GO:0052173response to defenses of other organism during symbiotic interaction0.00206049010094955
GO:0048290isotype switching to IgA isotypes0.00206049010094955
GO:0035306positive regulation of dephosphorylation0.00206049010094955
GO:0044413avoidance of host defenses0.00206049010094955
GO:0051834evasion or tolerance of defenses of other organism during symbiotic interaction0.00206049010094955
GO:0048298positive regulation of isotype switching to IgA isotypes0.00206049010094955
GO:0051832avoidance of defenses of other organism during symbiotic interaction0.00206049010094955
GO:0035304regulation of protein amino acid dephosphorylation0.00206049010094955
GO:0052200response to host defenses0.00206049010094955
GO:0048296regulation of isotype switching to IgA isotypes0.00206049010094955
GO:0035307positive regulation of protein amino acid dephosphorylation0.00206049010094955
GO:0009611response to wounding0.00257793593993739
GO:0051279regulation of release of sequestered calcium ion into cytosol0.00268755622605763
GO:0007406negative regulation of neuroblast proliferation0.00268755622605763
GO:0007184SMAD protein nuclear translocation0.00316989145488023
GO:0045806negative regulation of endocytosis0.00316989145488023
GO:0031536positive regulation of exit from mitosis0.00316989145488023
GO:0035303regulation of dephosphorylation0.00355241227247147
GO:0001784phosphotyrosine binding0.00355241227247147
GO:0048535lymph node development0.00355241227247147
GO:0009605response to external stimulus0.00374612507344501
GO:0045830positive regulation of isotype switching0.00374612507344501
GO:0008354germ cell migration0.00374612507344501
GO:0045309protein phosphorylated amino acid binding0.00374612507344501
GO:0051283negative regulation of sequestering of calcium ion0.00405788400909243
GO:0051282regulation of sequestering of calcium ion0.00405788400909243
GO:0051209release of sequestered calcium ion into cytosol0.00405788400909243
GO:0030279negative regulation of ossification0.00405788400909243
GO:0050777negative regulation of immune response0.00405788400909243
GO:0045191regulation of isotype switching0.00405788400909243
GO:0002683negative regulation of immune system process0.00405788400909243
GO:0031575G1/S transition checkpoint0.00405788400909243
GO:0051208sequestering of calcium ion0.00405788400909243
GO:0051219phosphoprotein binding0.00405788400909243
GO:0050764regulation of phagocytosis0.00405788400909243
GO:0006915apoptosis0.00405788400909243
GO:0012501programmed cell death0.00405788400909243
GO:0002208somatic diversification of immunoglobulins during immune response0.00405788400909243
GO:0002381immunoglobulin production during immune response0.00405788400909243
GO:0051101regulation of DNA binding0.00405788400909243
GO:0002204somatic recombination of immunoglobulin genes during immune response0.00405788400909243
GO:0005160transforming growth factor beta receptor binding0.00405788400909243
GO:0001837epithelial to mesenchymal transition0.00405788400909243
GO:0019048virus-host interaction0.00405788400909243
GO:0045190isotype switching0.00405788400909243
GO:0046851negative regulation of bone remodeling0.00405788400909243
GO:0050768negative regulation of neurogenesis0.00405788400909243
GO:0050680negative regulation of epithelial cell proliferation0.00405788400909243
GO:0050832defense response to fungus0.00405788400909243
GO:0016265death0.00405788400909243
GO:0008219cell death0.00405788400909243
GO:0016447somatic recombination of immunoglobulin gene segments0.00405788400909243
GO:0045930negative regulation of progression through mitotic cell cycle0.00405788400909243
GO:0016202regulation of striated muscle development0.00405788400909243
GO:0010458exit from mitosis0.00405788400909243
GO:0007096regulation of exit from mitosis0.00405788400909243
GO:0051238sequestering of metal ion0.00405788400909243
GO:0016444somatic cell DNA recombination0.00447846922097053
GO:0016445somatic diversification of immunoglobulins0.00447846922097053
GO:0002562somatic diversification of immune receptors via germline recombination within a single locus0.00447846922097053
GO:0002200somatic diversification of immune receptors0.00470872117487484
GO:0007405neuroblast proliferation0.00493247861524983
GO:0050679positive regulation of epithelial cell proliferation0.00501082262934408
GO:0002377immunoglobulin production0.00501082262934408
GO:0050871positive regulation of B cell activation0.00501082262934408
GO:0009620response to fungus0.00508305403775861
GO:0017015regulation of transforming growth factor beta receptor signaling pathway0.00508305403775861
GO:0030278regulation of ossification0.00508305403775861
GO:0006950response to stress0.00552651683656853
GO:0042306regulation of protein import into nucleus0.00552651683656853
GO:0051701interaction with host0.00552651683656853
GO:0000060protein import into nucleus, translocation0.00552651683656853
GO:0033157regulation of intracellular protein transport0.00552651683656853
GO:0048468cell development0.00563188635386827
GO:0051092activation of NF-kappaB transcription factor0.00564007429432708
GO:0046850regulation of bone remodeling0.00565877078367979
GO:0014031mesenchymal cell development0.00565877078367979
GO:0048762mesenchymal cell differentiation0.00565877078367979
GO:0051241negative regulation of multicellular organismal process0.00565877078367979
GO:0045937positive regulation of phosphate metabolic process0.00565877078367979
GO:0050864regulation of B cell activation0.00565877078367979
GO:0032386regulation of intracellular transport0.00565877078367979
GO:0042552myelination0.005821067193276
GO:0007093mitotic cell cycle checkpoint0.00591625123079949
GO:0002440production of molecular mediator of immune response0.00591625123079949
GO:0051223regulation of protein transport0.00600746294850141
GO:0051098regulation of binding0.00600746294850141
GO:0046822regulation of nucleocytoplasmic transport0.0061577800398386
GO:0051091positive regulation of transcription factor activity0.00621760082049371
GO:0050678regulation of epithelial cell proliferation0.00621760082049371
GO:0051051negative regulation of transport0.00621760082049371
GO:0001763morphogenesis of a branching structure0.00621760082049371
GO:0044403symbiosis, encompassing mutualism through parasitism0.00621760082049371
GO:0007272ensheathment of neurons0.00621760082049371
GO:0008366axon ensheathment0.00621760082049371
GO:0044419interspecies interaction between organisms0.00621760082049371
GO:0007346regulation of progression through mitotic cell cycle0.00621760082049371
GO:0050673epithelial cell proliferation0.00635188300532194
GO:0030100regulation of endocytosis0.00642418962948427
GO:0030424axon0.00642418962948427
GO:0030141secretory granule0.00692716904027421
GO:0050767regulation of neurogenesis0.00705019239876943
GO:0047485protein N-terminus binding0.00717101349592748
GO:0001508regulation of action potential0.00727858622798703
GO:0051235maintenance of localization0.00727858622798703
GO:0006909phagocytosis0.00727858622798703
GO:0030217T cell differentiation0.00727858622798703
GO:0006793phosphorus metabolic process0.00739714753182425
GO:0006796phosphate metabolic process0.00739714753182425
GO:0001666response to hypoxia0.00820673422484349
GO:0048869cellular developmental process0.00820673422484349
GO:0030154cell differentiation0.00820673422484349
GO:0007179transforming growth factor beta receptor signaling pathway0.00843866546840953
GO:0016064immunoglobulin mediated immune response0.0084684843854286
GO:0051251positive regulation of lymphocyte activation0.0084684843854286
GO:0051090regulation of transcription factor activity0.00849735185625042
GO:0019724B cell mediated immunity0.00849735185625042
GO:0030308negative regulation of cell growth0.00859244092463929
GO:0045792negative regulation of cell size0.008686039487641
GO:0000075cell cycle checkpoint0.00893765386618177
GO:0022415viral reproductive process0.00902714296975374
GO:0042113B cell activation0.00951369295350302
GO:0045926negative regulation of growth0.00951369295350302
GO:0010033response to organic substance0.00959680958217342
GO:0042493response to drug0.009678681137634
GO:0030098lymphocyte differentiation0.00975933528817835
GO:0007088regulation of mitosis0.0101412323453735
GO:0051174regulation of phosphorus metabolic process0.0102921391075896
GO:0019220regulation of phosphate metabolic process0.0102921391075896
GO:0007204elevation of cytosolic calcium ion concentration0.0102921391075896
GO:0051480cytosolic calcium ion homeostasis0.0102921391075896
GO:0002449lymphocyte mediated immunity0.0105108110616537
GO:0043687post-translational protein modification0.0106637744193752
GO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway0.0107141565090489
GO:0002250adaptive immune response0.0107141565090489
GO:0002460adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.0107141565090489
GO:0051249regulation of lymphocyte activation0.0107141565090489
GO:0051093negative regulation of developmental process0.0107811289564368
GO:0002443leukocyte mediated immunity0.0108471922724222
GO:0050865regulation of cell activation0.0110503331282197
GO:0043005neuron projection0.011113708774458
GO:0051247positive regulation of protein metabolic process0.0115846157013033
GO:0007166cell surface receptor linked signal transduction0.0116834586654113
GO:0014706striated muscle development0.0116834586654113
GO:0001503ossification0.0116834586654113
GO:0031214biomineral formation0.0116834586654113
GO:0002521leukocyte differentiation0.0118720457812149
GO:0046849bone remodeling0.012502112220223
GO:0006606protein import into nucleus0.012502112220223
GO:0051170nuclear import0.0125243917682088
GO:0042110T cell activation0.0125243917682088
GO:0050776regulation of immune response0.0125243917682088
GO:0002682regulation of immune system process0.0127007283478821
GO:0007050cell cycle arrest0.0127488499470269
GO:0048771tissue remodeling0.0131721626333633
GO:0006464protein modification process0.0134340631775533
GO:0002252immune effector process0.0135505160932149
GO:0051049regulation of transport0.0135505160932149
GO:0045087innate immune response0.0139588481081739
GO:0055074calcium ion homeostasis0.0140362234715278
GO:0006874cellular calcium ion homeostasis0.0140362234715278
GO:0043412biopolymer modification0.0140489859928888
GO:0017038protein import0.0145395928833342
GO:0006875cellular metal ion homeostasis0.0145395928833342
GO:0055065metal ion homeostasis0.0145395928833342
GO:0042060wound healing0.0153949540833138
GO:0006913nucleocytoplasmic transport0.017988952623837
GO:0046649lymphocyte activation0.0180032059714914
GO:0051169nuclear transport0.0180172957615725
GO:0030097hemopoiesis0.0184895278787589
GO:0001558regulation of cell growth0.0185007391088173
GO:0032502developmental process0.0187647019955975
GO:0007517muscle development0.0194240394070176
GO:0048534hemopoietic or lymphoid organ development0.0194299237665899
GO:0045321leukocyte activation0.0199954876014571
GO:0030005cellular di-, tri-valent inorganic cation homeostasis0.0199954876014571
GO:0002520immune system development0.0201083690822038
GO:0055066di-, tri-valent inorganic cation homeostasis0.0201104356201654
GO:0006310DNA recombination0.0213027112445465
GO:0010324membrane invagination0.0213027112445465
GO:0006897endocytosis0.0213027112445465
GO:0030003cellular cation homeostasis0.0213961365321492
GO:0016049cell growth0.0213961365321492
GO:0040008regulation of growth0.0213961365321492
GO:0055080cation homeostasis0.0214970119510755
GO:0008361regulation of cell size0.0215911465360642
GO:0051707response to other organism0.0215911465360642
GO:0001775cell activation0.0216833518416847
GO:0001501skeletal development0.0216833518416847
GO:0006917induction of apoptosis0.021876068821807
GO:0012502induction of programmed cell death0.021876068821807
GO:0004725protein tyrosine phosphatase activity0.0221662759483106
GO:0006605protein targeting0.0221662759483106
GO:0045893positive regulation of transcription, DNA-dependent0.0225409065093586
GO:0008285negative regulation of cell proliferation0.0225409065093586
GO:0045786negative regulation of progression through cell cycle0.0225409065093586
GO:0008284positive regulation of cell proliferation0.0231140999528246
GO:0016477cell migration0.0231140999528246
GO:0050793regulation of developmental process0.0231736693375057
GO:0006873cellular ion homeostasis0.0231736693375057
GO:0055082cellular chemical homeostasis0.0231736693375057
GO:0007067mitosis0.0232577860515655
GO:0048699generation of neurons0.0234376026025504
GO:0000087M phase of mitotic cell cycle0.0236157051062257
GO:0008083growth factor activity0.0242700046495253
GO:0043065positive regulation of apoptosis0.0244424856494988
GO:0043068positive regulation of programmed cell death0.0245186743594489
GO:0022008neurogenesis0.024782603119839
GO:0007276gamete generation0.0248564992906902
GO:0050801ion homeostasis0.0250230604966794
GO:0051239regulation of multicellular organismal process0.0258384340947735
GO:0045941positive regulation of transcription0.025906467296979
GO:0016044membrane organization and biogenesis0.0262500139072716
GO:0045935positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0264182343048339
GO:0009607response to biotic stimulus0.0264182343048339
GO:0006954inflammatory response0.0264182343048339
GO:0016481negative regulation of transcription0.0264182343048339
GO:0007167enzyme linked receptor protein signaling pathway0.0271117065808389
GO:0048878chemical homeostasis0.0271719441412501
GO:0009888tissue development0.0271726741397441
GO:0022414reproductive process0.0271726741397441
GO:0000279M phase0.0271726741397441
GO:0016563transcription activator activity0.0273195892415244
GO:0042995cell projection0.0274350947975721
GO:0004721phosphoprotein phosphatase activity0.0274350947975721
GO:0019953sexual reproduction0.0274920948196355
GO:0045934negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0277215898472288
GO:0000278mitotic cell cycle0.0282074449957576
GO:0019226transmission of nerve impulse0.0284318936848912
GO:0051704multi-organism process0.0285690544056786
GO:0016023cytoplasmic membrane-bound vesicle0.0296399746567695
GO:0031988membrane-bound vesicle0.02990063306683
GO:0000074regulation of progression through cell cycle0.02990063306683
GO:0051726regulation of cell cycle0.0302810314848609
GO:0009887organ morphogenesis0.0304075868306677
GO:0031325positive regulation of cellular metabolic process0.0305330867900803
GO:0022403cell cycle phase0.0307403978631971
GO:0019725cellular homeostasis0.0311110003802775
GO:0031324negative regulation of cellular metabolic process0.0313896883456635
GO:0006928cell motility0.0313896883456635
GO:0051674localization of cell0.0313896883456635
GO:0009893positive regulation of metabolic process0.0318139601688625
GO:0007165signal transduction0.0318139601688625
GO:0005578proteinaceous extracellular matrix0.0340217146424188
GO:0051246regulation of protein metabolic process0.0340217146424188
GO:0031410cytoplasmic vesicle0.0341276918296541
GO:0031982vesicle0.0345507055252033
GO:0009892negative regulation of metabolic process0.0347328780898267
GO:0016791phosphoric monoester hydrolase activity0.0347559323918043
GO:0007154cell communication0.0361918096548299
GO:0044267cellular protein metabolic process0.0363645558128093
GO:0042127regulation of cell proliferation0.0367711650166377
GO:0044260cellular macromolecule metabolic process0.037023657213381
GO:0032989cellular structure morphogenesis0.0370459803513501
GO:0000902cell morphogenesis0.0370459803513501
GO:0042592homeostatic process0.0370595047182018
GO:0019538protein metabolic process0.0391184422583096
GO:0005615extracellular space0.0403561355709879
GO:0006886intracellular protein transport0.0403561355709879
GO:0042981regulation of apoptosis0.0432959286704676
GO:0042578phosphoric ester hydrolase activity0.0434249170822596
GO:0043067regulation of programmed cell death0.0434249170822596
GO:0006952defense response0.0438609639151437
GO:0042221response to chemical stimulus0.0440711758487935
GO:0016192vesicle-mediated transport0.0451662904214498
GO:0022402cell cycle process0.046399908682708
GO:0007267cell-cell signaling0.0473308073613599
GO:0065009regulation of a molecular function0.049421473323182



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell1.33e-82172
angioblastic mesenchymal cell1.33e-82172
hematopoietic oligopotent progenitor cell3.42e-78165
hematopoietic multipotent progenitor cell3.42e-78165
leukocyte7.16e-74140
hematopoietic cell8.55e-74182
hematopoietic lineage restricted progenitor cell8.95e-63124
nongranular leukocyte1.57e-59119
myeloid cell9.64e-49112
common myeloid progenitor9.64e-49112
myeloid leukocyte6.27e-4176
granulocyte monocyte progenitor cell3.54e-3671
myeloid lineage restricted progenitor cell4.10e-3570
macrophage dendritic cell progenitor3.54e-3265
monopoietic cell4.50e-3163
monocyte4.50e-3163
monoblast4.50e-3163
promonocyte4.50e-3163
CD14-positive, CD16-negative classical monocyte2.91e-3042
classical monocyte1.11e-2645
lymphocyte1.31e-2453
common lymphoid progenitor1.31e-2453
lymphoid lineage restricted progenitor cell3.81e-2452
lymphocyte of B lineage2.15e-1324
pro-B cell2.15e-1324
mesenchymal cell1.44e-11358
T cell5.49e-1125
pro-T cell5.49e-1125
connective tissue cell2.19e-10365
B cell4.50e-1014
mature alpha-beta T cell5.13e-1018
alpha-beta T cell5.13e-1018
immature T cell5.13e-1018
mature T cell5.13e-1018
immature alpha-beta T cell5.13e-1018
intermediate monocyte3.03e-089
CD14-positive, CD16-positive monocyte3.03e-089
motile cell5.53e-08390
granulocyte1.49e-078
CD8-positive, alpha-beta T cell3.73e-0711
Uber Anatomy
Ontology termp-valuen
hematopoietic system5.39e-40102
blood island5.39e-40102
hemolymphoid system3.76e-35112
bone marrow1.55e-3080
bone element3.92e-2686
immune system8.71e-23115
adult organism8.97e-23115
skeletal element7.15e-19101
skeletal system7.15e-19101
connective tissue3.63e-09375
lateral plate mesoderm7.39e-07216
Disease
Ontology termp-valuen
hematologic cancer4.34e-1151
immune system cancer4.34e-1151
leukemia2.36e-1039
myeloid leukemia1.34e-0731


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.