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Coexpression cluster:C3330

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Full id: C3330_Hepatocyte_liver_Mesenchymal_tenocyte_Synoviocyte_Fibroblast_Nucleus



Phase1 CAGE Peaks

Hg19::chr12:7245125..7245138,-p3@C1R
Hg19::chr12:7245139..7245150,-p4@C1R
Hg19::chr12:7245152..7245169,-p5@C1R


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
multi-tissue structure3.08e-19342
anatomical cluster6.54e-14373
mesenchyme1.91e-13160
entire embryonic mesenchyme1.91e-13160
trunk mesenchyme2.50e-12122
organism subdivision7.86e-12264
multi-cellular organism1.40e-11656
muscle tissue1.74e-1064
musculature1.74e-1064
musculature of body1.74e-1064
skeletal muscle tissue5.12e-1062
striated muscle tissue5.12e-1062
myotome5.12e-1062
dense mesenchyme tissue2.07e-0973
primordium2.66e-09160
paraxial mesoderm4.01e-0972
presumptive paraxial mesoderm4.01e-0972
somite5.26e-0971
presomitic mesoderm5.26e-0971
presumptive segmental plate5.26e-0971
dermomyotome5.26e-0971
trunk paraxial mesoderm5.26e-0971
cell layer1.72e-08309
epithelium1.79e-08306
anatomical system2.16e-08624
anatomical group2.75e-08625
multilaminar epithelium2.96e-0883
epithelial vesicle5.76e-0878
trunk1.43e-07199
primary circulatory organ2.57e-0727
digestive system3.07e-07145
digestive tract3.07e-07145
primitive gut3.07e-07145
surface structure4.67e-0799
heart6.01e-0724
primitive heart tube6.01e-0724
primary heart field6.01e-0724
anterior lateral plate mesoderm6.01e-0724
heart tube6.01e-0724
heart primordium6.01e-0724
cardiac mesoderm6.01e-0724
cardiogenic plate6.01e-0724
heart rudiment6.01e-0724
organ system subdivision8.45e-07223
unilaminar epithelium8.56e-07148


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105137.971147625824820.001974187055288560.0115031311017229
CTCF#1066435.360256373075030.0064925092527670.0278697564262118
CTCFL#140690319.74647435897440.0001298372005551160.00171386089342465
POU2F2#545239.106124057742520.001324165192682130.00880520110521641
RAD21#5885310.35503389545630.0009004912073565420.00662485215589672
SMC3#9126315.04493284493280.0002935825420371870.00308403410861212
STAT3#6774310.51946499715420.0008589184530415310.00641663693256112
YY1#752834.911170749853860.008441455341808260.0328373493162661
ZNF143#7702313.50087655222790.0004062804962997170.00388176093248981



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.