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Coexpression cluster:C3819

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Full id: C3819_testicular_Mast_hepatoblastoma_endometrial_cerebellum_cord_H9



Phase1 CAGE Peaks

Hg19::chr19:52408227..52408243,-p2@ZNF649
Hg19::chr19:52408257..52408278,-p1@ZNF649
Hg19::chr19:52408285..52408310,-p3@ZNF649


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism1.12e-33115
central nervous system9.08e-2382
neural tube1.08e-2257
neural rod1.08e-2257
future spinal cord1.08e-2257
neural keel1.08e-2257
regional part of nervous system1.12e-2194
nervous system1.12e-2194
regional part of forebrain4.95e-1941
forebrain4.95e-1941
future forebrain4.95e-1941
regional part of brain9.46e-1959
anterior neural tube1.22e-1842
brain1.51e-1669
future brain1.51e-1669
gray matter6.69e-1634
brain grey matter6.69e-1634
telencephalon7.18e-1634
regional part of telencephalon2.09e-1533
neurectoderm2.53e-1590
neural plate7.12e-1586
presumptive neural plate7.12e-1586
cerebral hemisphere1.29e-1432
pre-chordal neural plate3.46e-1161
ectoderm5.82e-11173
presumptive ectoderm5.82e-11173
cerebral cortex7.86e-1125
pallium7.86e-1125
regional part of cerebral cortex1.26e-1022
ectoderm-derived structure1.66e-10169
neocortex1.67e-0920
anterior region of body5.69e-08129
craniocervical region5.69e-08129
head2.78e-07123
nucleus of brain9.97e-079
neural nucleus9.97e-079


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL3#602334.54710280373832.42397750207122e-050.000526972910780217
CTCF#1066435.360256373075030.0064925092527670.0279432610998819
CTCFL#140690319.74647435897440.0001298372005551160.0017173337625096
E2F4#1874312.66806031528440.0004917987006298980.00437280474162149
E2F6#187635.017155731697390.00791769806886330.0322221279123257
EGR1#195834.988179094810140.008056488137383440.0320647675233486
ELF1#199734.258097958807540.01295179875054610.0462278428525438
ETS1#211339.728760922202340.001085840092584840.0076232894211796
NR3C1#2908314.9730233311730.0002978331194675480.00309014436360732
REST#597839.650028716128020.001112636247114590.0076752058792867
SIN3A#2594235.408884726815140.006318961977991520.0276764969603463
SIRT6#515483153.6384039900252.75057764221434e-071.3978957585169e-05
SIX5#147912317.0867153554590.0002004060546325010.00239722917647048
SP2#6668326.15353049384465.58768218891694e-050.000940486607781299
TAF7#6879311.43306940492390.0006690181981945830.00542987189938173
TCF7L2#6934310.77017656313730.0008003181298398380.00613779006919833
TRIM28#10155318.59052504526250.0001555969297255280.00197046050001265
YY1#752834.911170749853860.008441455341808260.0329391800651266
ZEB1#6935316.88843201754390.0002075486917327580.00242734354041181
ZNF143#7702313.50087655222790.0004062804962997170.00389065915579003



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.