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Coexpression cluster:C4052

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Full id: C4052_Eosinophils_CD19_Natural_CD8_Whole_CD4_Basophils



Phase1 CAGE Peaks

Hg19::chr20:56195449..56195459,-p4@ZBP1
Hg19::chr20:56195474..56195506,-p1@ZBP1
Hg19::chr20:56195509..56195520,-p3@ZBP1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte2.71e-63140
nongranular leukocyte3.34e-52119
hematopoietic lineage restricted progenitor cell3.42e-51124
hematopoietic stem cell9.38e-43172
angioblastic mesenchymal cell9.38e-43172
hematopoietic oligopotent progenitor cell1.62e-40165
hematopoietic multipotent progenitor cell1.62e-40165
hematopoietic cell1.31e-38182
myeloid leukocyte5.32e-2976
lymphocyte1.56e-2853
common lymphoid progenitor1.56e-2853
lymphoid lineage restricted progenitor cell3.68e-2852
CD14-positive, CD16-negative classical monocyte1.93e-2642
classical monocyte1.54e-2345
granulocyte monocyte progenitor cell6.28e-2371
myeloid lineage restricted progenitor cell1.38e-2170
macrophage dendritic cell progenitor2.95e-2165
monopoietic cell1.59e-2063
monocyte1.59e-2063
monoblast1.59e-2063
promonocyte1.59e-2063
mature alpha-beta T cell5.42e-1618
alpha-beta T cell5.42e-1618
immature T cell5.42e-1618
mature T cell5.42e-1618
immature alpha-beta T cell5.42e-1618
myeloid cell6.94e-15112
common myeloid progenitor6.94e-15112
T cell2.93e-1425
pro-T cell2.93e-1425
lymphocyte of B lineage2.76e-1224
pro-B cell2.76e-1224
CD8-positive, alpha-beta T cell1.16e-1011
B cell5.75e-1014
granulocyte2.61e-088
intermediate monocyte2.25e-079
CD14-positive, CD16-positive monocyte2.25e-079
Uber Anatomy
Ontology termp-valuen
hematopoietic system4.83e-31102
blood island4.83e-31102
hemolymphoid system6.26e-28112
bone marrow2.89e-1980
adult organism6.16e-18115
bone element1.60e-1686
immune system7.72e-15115
skeletal element6.70e-13101
skeletal system6.70e-13101
blood2.35e-0915
haemolymphatic fluid2.35e-0915
organism substance2.35e-0915


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.