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{{f5samples
{{f5samples
|DRA_sample_Accession=CAGE@SAMD00005392
|DRA_sample_Accession=CAGE@SAMD00005392
|accession_numbers=CAGE;DRX008661;DRR009533;DRZ000958;DRZ002343
|accession_numbers=CAGE;DRX008661;DRR009533;DRZ000958;DRZ002343;DRZ012308;DRZ013693
|ancestors_in_anatomy_facet=UBERON:0000468,UBERON:0007023,UBERON:0007100,UBERON:0000948,UBERON:0002146,UBERON:0000479,UBERON:0004121,UBERON:0000064,UBERON:0010314,UBERON:0000062,UBERON:0004120,UBERON:0000061,UBERON:0000465,UBERON:0000467,UBERON:0010313,UBERON:0001062,UBERON:0000480,UBERON:0003103,UBERON:0003978,UBERON:0000946,UBERON:0005623,UBERON:0010317,UBERON:0004535,UBERON:0001009
|ancestors_in_anatomy_facet=UBERON:0000468,UBERON:0007023,UBERON:0007100,UBERON:0000948,UBERON:0002146,UBERON:0000479,UBERON:0004121,UBERON:0000064,UBERON:0010314,UBERON:0000062,UBERON:0004120,UBERON:0000061,UBERON:0000465,UBERON:0000467,UBERON:0010313,UBERON:0001062,UBERON:0000480,UBERON:0003103,UBERON:0003978,UBERON:0000946,UBERON:0005623,UBERON:0010317,UBERON:0004535,UBERON:0001009
|ancestors_in_cell_lineage_facet=
|ancestors_in_cell_lineage_facet=
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|fonse_treatment_closure=
|fonse_treatment_closure=
|has_quality=
|has_quality=
|hg19bam=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.tissue.hCAGE/heart%2520-%2520pulmonic%2520valve%252c%2520adult.CNhs12856.10206-103F8.hg19.nobarcode.bam
|hg19ctss=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.tissue.hCAGE/heart%2520-%2520pulmonic%2520valve%252c%2520adult.CNhs12856.10206-103F8.hg19.ctss.bed.gz
|hg19fasta=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.tissue.hCAGE/heart%2520-%2520pulmonic%2520valve%252c%2520adult.CNhs12856.10206-103F8.hg19.nobarcode.rdna.fa.gz
|hg38bam=http://fantom.gsc.riken.jp/5/datafiles/reprocessed/hg38_v2/basic/human.tissue.hCAGE/heart%2520-%2520pulmonic%2520valve%252c%2520adult.CNhs12856.10206-103F8.hg38.nobarcode.bam
|hg38ctss=http://fantom.gsc.riken.jp/5/datafiles/reprocessed/hg38_v2/basic/human.tissue.hCAGE/heart%2520-%2520pulmonic%2520valve%252c%2520adult.CNhs12856.10206-103F8.hg38.nobarcode.ctss.bed.gz
|id=FF:10206-103F8
|id=FF:10206-103F8
|is_a=EFO:0002091;;FF:0010206
|is_a=EFO:0002091;;FF:0010206
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|library_id=CNhs12856
|library_id=CNhs12856
|library_id_phase_based=2:CNhs12856
|library_id_phase_based=2:CNhs12856
|microRNAs=
|microRNAs_nn=
|microRNAs_nonnovel_cage=http://fantom.gsc.riken.jp/5/suppl/De_Rie_et_al_2017/vis_viewer/#/human#cage;sample;10206
|microRNAs_novel_cage=http://fantom.gsc.riken.jp/5/suppl/De_Rie_et_al_2017/vis_viewer_novel/#/human#cage;sample;10206
|name=heart - pulmonic valve, adult
|name=heart - pulmonic valve, adult
|namespace=FANTOM5
|namespace=FANTOM5
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|profile_rnaseq=
|profile_rnaseq=
|profile_srnaseq=,,,
|profile_srnaseq=,,,
|refex=http://refex.dbcls.jp/genelist.php?lang
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Line 91: Line 101:
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|top_motifs=MEF2{A,B,C,D}:6.23922940578;NR1H4:3.44257457613;GATA4:3.34015983518;SRF:3.3344799272;NR5A1,2:2.91345490402;MYBL2:2.55015529006;NFE2L1:2.45778870488;IKZF2:2.39657139457;ESRRA:2.27391482833;NFATC1..3:2.2249070483;TGIF1:2.15739164685;PRDM1:2.09628032036;PAX6:1.9725326179;TFAP2{A,C}:1.96002629774;RBPJ:1.94553731826;HAND1,2:1.92859284852;SPZ1:1.92787565208;SOX5:1.92143109947;XBP1:1.90203544167;GCM1,2:1.89045957236;AR:1.86572437073;TFAP4:1.80324790235;RREB1:1.76328244255;KLF4:1.75109311495;TLX1..3_NFIC{dimer}:1.71452049747;HOX{A4,D4}:1.69362037499;TFCP2:1.67211791893;NKX2-1,4:1.66633776728;MAFB:1.63189350308;RXR{A,B,G}:1.43989996944;CUX2:1.4357639096;HIC1:1.43521481211;FOXO1,3,4:1.42991689476;MAZ:1.40760276482;TEAD1:1.37144534428;PDX1:1.32946570903;STAT1,3:1.3217549579;EP300:1.32035541507;FOXL1:1.31686761043;ZNF384:1.30044395601;RXR{A,B,G}_{NR1H2,PPAR}dimers:1.28962684898;PATZ1:1.27388122951;MZF1:1.26403265135;GATA6:1.22467539396;MTE{core}:1.22127174065;EVI1:1.20913486508;GTF2A1,2:1.1866014331;SMAD1..7,9:1.17112253821;TLX2:1.15072136584;NR3C1:1.14746918374;FOXP1:1.10819866901;TFAP2B:1.07720266802;MED-1{core}:1.01086720935;NHLH1,2:0.985869246228;GTF2I:0.961769540178;SP1:0.938723442258;CDC5L:0.897177384726;EGR1..3:0.885602505685;ZFP161:0.881840387004;RORA:0.868638709741;PAX5:0.858208371107;ZNF423:0.823689876719;GFI1B:0.81199025035;ATF2:0.805937437417;ALX1:0.79703110193;ZBTB16:0.795253196897;UFEwm:0.780223684652;ZIC1..3:0.774346333835;NKX3-2:0.773099321551;BREu{core}:0.772471019756;BPTF:0.76240952191;MTF1:0.754941304428;FOX{D1,D2}:0.749819072914;MYFfamily:0.74171136773;POU3F1..4:0.729657531541;ZNF238:0.712813982211;CDX1,2,4:0.704961756988;POU6F1:0.704832806412;IRF7:0.662217460679;IKZF1:0.652654178345;TOPORS:0.64953368785;NKX3-1:0.614767594163;HOX{A6,A7,B6,B7}:0.598534400938;EBF1:0.595481873797;PPARG:0.593660562281;NFIX:0.575345853596;HBP1_HMGB_SSRP1_UBTF:0.553374447126;HOXA9_MEIS1:0.530690068681;FOXP3:0.460803198945;PITX1..3:0.418257815577;SOX17:0.395443083891;NFIL3:0.379125030693;FOXA2:0.371644232692;T:0.361584399982;REST:0.332995380246;NKX2-2,8:0.316381206937;RXRA_VDR{dimer}:0.289331339924;NKX6-1,2:0.277338263443;GZF1:0.267386463631;ZBTB6:0.251974312784;LMO2:0.219356656809;NANOG:0.189126886733;SREBF1,2:0.151880338661;EN1,2:0.150528111295;XCPE1{core}:0.130378237324;TBP:0.12811756754;HMGA1,2:0.124339001545;HMX1:0.119161910475;HSF1,2:0.103331692484;FOX{F1,F2,J1}:0.0681489211944;TEF:0.0617499753585;RFX2..5_RFXANK_RFXAP:0.0497845660911;TBX4,5:0.0372965889634;NR6A1:0.0157671625356;ATF4:-0.0486626648567;HNF4A_NR2F1,2:-0.0540151469835;FOSL2:-0.0569283847537;HOX{A5,B5}:-0.0620274584694;IRF1,2:-0.0717276902155;JUN:-0.089865700935;CREB1:-0.111455952135;ATF6:-0.139837950454;PAX4:-0.15655212367;ESR1:-0.157060786471;SNAI1..3:-0.177037214592;AIRE:-0.193281197441;ALX4:-0.193408039766;SOX{8,9,10}:-0.194608033966;HNF1A:-0.195539940716;MYOD1:-0.228156580447;ATF5_CREB3:-0.240143188152;ETS1,2:-0.248250182665;FOXQ1:-0.249595896502;PBX1:-0.262957280886;GLI1..3:-0.268270798672;ONECUT1,2:-0.289489325246;SPI1:-0.299388661779;FOX{I1,J2}:-0.316951554651;ZNF143:-0.322148599358;STAT2,4,6:-0.326268369527;ADNP_IRX_SIX_ZHX:-0.329488336959;FOXN1:-0.373925739341;NRF1:-0.391586158962;LHX3,4:-0.394007219046;ARID5B:-0.424154089352;SPIB:-0.433451858135;YY1:-0.48229499779;ZNF148:-0.535576943153;CEBPA,B_DDIT3:-0.588430949028;FOXD3:-0.59552601046;ZEB1:-0.613784246056;TP53:-0.631754720418;RFX1:-0.68594116677;ELF1,2,4:-0.735320756593;GFI1:-0.748427989401;AHR_ARNT_ARNT2:-0.759232581868;HLF:-0.763975495429;PAX2:-0.782815653827;NFE2:-0.801382938921;SOX2:-0.80333428655;FOXM1:-0.805345672531;TAL1_TCF{3,4,12}:-0.805901850718;STAT5{A,B}:-0.816028384805;LEF1_TCF7_TCF7L1,2:-0.836261612214;NFKB1_REL_RELA:-0.871228188243;DMAP1_NCOR{1,2}_SMARC:-0.879216727665;POU1F1:-0.92800693107;PRRX1,2:-0.945173203936;TFDP1:-0.95808680163;NKX2-3_NKX2-5:-1.01726055579;BACH2:-1.0388877624;E2F1..5:-1.08241295534;FOS_FOS{B,L1}_JUN{B,D}:-1.11763726201;NFY{A,B,C}:-1.1273311547;NANOG{mouse}:-1.13864652486;NFE2L2:-1.16001077437;VSX1,2:-1.19061079017;RUNX1..3:-1.26022871288;POU5F1:-1.28037336526;DBP:-1.41166770512;CRX:-1.47644076931;PAX1,9:-1.52335682463;bHLH_family:-1.54384047106;ELK1,4_GABP{A,B1}:-1.67360355583;PAX3,7:-1.74578356497;MYB:-1.81148729863;OCT4_SOX2{dimer}:-1.82560790131;HES1:-1.82983625564;ARNT_ARNT2_BHLHB2_MAX_MYC_USF1:-1.92389168145;POU2F1..3:-1.97047458467;HIF1A:-2.06695201162;PAX8:-2.43709608058
|xref=
|xref=
|zenbu_report=https://fantom.gsc.riken.jp/zenbu/reports/#miRNA_expression_atlas_human;search_select_hide=table111:FF:10206-103F8;search_select_hide=table117:FF:10206-103F8
}}
}}

Latest revision as of 13:56, 3 June 2020

Name:heart - pulmonic valve, adult
Species:Human (Homo sapiens)
Library ID:CNhs12856
Sample type:tissues
Genomic View: UCSC
RefEX:Specific genes
FANTOM CAT:1, 2, 3, 4, 5, 6, 7
CAGEd-oPOSSUM:link
ZENBU report :link
Additional information
Sample information
strainNA
tissueNA
dev stageNA
sexM
age26
cell typeCELL MIXTURE - tissue sample
cell lineNA
companyBiochain
collaborationNA
External link for information[{{{sample_info_link}}} {{{sample_info_link}}}]
RNA information
lot numberNA
catalog numberR1234135-10
sample typeNA
extraction protocol (Details)NA

CAGE Accession numbers
MethodSample accession id
CAGE  SAMD00005392
Library accession numbers

Library idMethodExp. accession idRun accession id
CNhs12856 CAGE DRX008661 DRR009533
Accession ID Hg19

Library idBAMCTSS
CNhs12856 DRZ000958 DRZ002343
Accession ID Hg38

Library idBAMCTSS
CNhs12856 DRZ012308 DRZ013693
Download raw sequence, BAM & CTSS
Hg19
FastaBAMCTSS
downloaddownloaddonwload
Hg38
BAMCTSS
downloaddonwload


Relative expression to median (log10)


Transcription factors with enriched expression in this sampleRanked list of transcription factor promoter expression in this sample relative to the median expression in the FANTOM5 collection is shown. Value is log10 transformed.



Co-expression clusters with enriched expression in this sampleRanked list of co-expression cluster expression in this sample relative to the median expression in the FANTOM5 collection is shown. Value is log10 transformed. <br>Analyst:NA <br><br>link to dataset.<br>data

Coexpression clusterscore
C0-CD14-Eosinophils-Neutrophils-Basophils-CD34-immature-Peripheral0
C1-testis-epididymis-embryonic-medulla-pituitary-trachea-caudate0
C10-occipital-temporal-parietal-brain-duodenum-Neurons-Neural0
C100-rhabdomyosarcoma-gastric-pineal-Wilms-cervical-mesodermal-endometrial0
C101-small-cerebellum-maxillary-colon-parietal-epididymis-merkel0
C102-neuroblastoma-testicular-pituitary-carcinosarcoma-rectum-acantholytic-iPS0
C103-CD4-CD8-Natural-Peripheral-Whole-Neutrophils-Basophils0
C104-Mast-Basophils-immature-CD14-CD34-eye-Natural0
C105-heart-skeletal-occipital-hippocampus-acute-Sebocyte-penis1.208
C106-Hep2-epitheloid-placenta-cervical-rectal-anaplastic-glassy0
C107-Neutrophils-CD14-Eosinophils-Monocytederived-Whole-Peripheral-blood0
C108-breast-hepatoblastoma-MCF7-parotid-salivary-submaxillary-prostate0
C109-Reticulocytes-non-acute-Hodgkin-Burkitt-retinoblastoma-lymphoma-0.382
C11-cerebellum-medulla-pons-parietal-occipital-middle-medial0
C110-leukemia-chronic-Eosinophils-acute-Whole-CD34-Lymphatic0
C111-medulla-lung-trachea-testis-caudate-epididymis-throat0
C112-gastric-pancreas-temporal-duodenum-small-extraskeletal-adrenal0
C113-thyroid-throat-lung-lymph-small-colon-trachea0
C114-teratocarcinoma-medulloblastoma-carcinosarcoma-iPS-anaplastic-acute-neuroblastoma0
C115-pituitary-Neural-caudate-putamen-amygdala-medulla-hippocampus0
C116-myeloma-xeroderma-tonsil-CD19-spleen-lymph-trachea0
C117-serous-clear-kidney-neuroectodermal-mesothelioma-endometrial-Intestinal0
C118-cerebellum-parietal-occipital-medial-middle-frontal-insula0
C119-CD4-CD8-Natural-Neutrophils-CD14-Peripheral-CD190.0896
C12-Mast-Basophils-immature-chorionic-mature-CD14-Eosinophils0
C120-immature-salivary-tongue-skin-cervical-CD14-CD340
C121-NK-Natural-CD8-CD4-anaplastic-chronic-B0
C122-chronic-Reticulocytes-skeletal-leukemia-acute-colon-Tracheal0
C123-CD19-Natural-CD8-CD4-CD14-Peripheral-Basophils0
C124-small-temporal-duodenum-colon-gall-signet-Hepatocyte0
C125-mucinous-alveolar-mesothelioma-Smooth-lung-CD14-Nucleus0
C126-gastrointestinal-argyrophil-smallcell-merkel-bile-insula-brain0
C127-maxillary-small-hepatoblastoma-hepatocellular-alveolar-colon-argyrophil0
C128-testicular-choriocarcinoma-H9-teratocarcinoma-pancreatic-iPS-HES3GFP0
C129-liver-Hepatocyte-colon-duodenum-temporal-testicular-small0
C13-Neutrophils-Eosinophils-CD14-Monocytederived-Whole-Peripheral-CD40
C130-iPS-HES3GFP-H9-teratocarcinoma-testicular-colon-Alveolar0
C131-lung-trachea-Alveolar-thyroid-umbilical-throat-skin0
C132-acute-small-Dendritic-Macrophage-CD14-Neutrophils-Monocytederived0
C133-signet-gall-small-kidney-colon-ductal-adenocarcinoma0
C134-skeletal-diaphragm-tongue-throat-Skeletal-skin-penis0
C135-neuroblastoma-retinoblastoma-carcinoid-choriocarcinoma-testicular-acute-rectum0
C136-Wilms-extraskeletal-anaplastic-rhabdomyosarcoma-cholangiocellular-nonsmall-neuroectodermal0
C137-large-ductal-melanoma-cervical-Endothelial-Smooth-chronic0
C138-diffuse-Burkitt-lymphangiectasia-lymphoma-acute-CD19-pineal0
C139-astrocytoma-skin-salivary-gall-serous-Mallassezderived-renal0
C14-Whole-blood-Reticulocytes-liver-Neutrophils-Eosinophils-spleen0
C140-Renal-Endothelial-Hepatic-Lymphatic-heart-lung-spleen0.416
C141-Hodgkin-acute-thymus-chronic-vein-CD4-B0
C142-Preadipocyte-Fibroblast-hepatic-Ewing-Adipocyte-Olfactory-Hair0
C143-Monocytederived-CD14-Macrophage-Dendritic-Basophils-CD14CD16-Osteoblast0
C144-CD4-tonsil-NK-appendix-CD8-splenic-mycosis0
C145-neuroblastoma-peripheral-neuroectodermal-neuroepithelioma-carcinoid-adult-extraskeletal0
C146-lymphangiectasia-lymphoma-gall-lymph-tonsil-gastric-transitionalcell0
C147-Neutrophils-Eosinophils-CD4-CD14-CD8-Natural-Peripheral0.0233
C148-kidney-small-epididymis-pancreas-serous-duodenum-temporal0
C149-occipital-medial-brain-amygdala-parietal-cerebral-cerebellum0
C15-anaplastic-small-skeletal-neuroblastoma-parietal-temporal-tongue0
C150-merkel-carcinoid-nonsmall-gastrointestinal-argyrophil-pineal-small0
C151-CD14-Natural-Basophils-CD8-Eosinophils-CD4-Mast0
C152-peripheral-neuroectodermal-neuroepithelioma-neuroblastoma-testicular-carcinoid-lung0
C153-rhabdomyosarcoma-liposarcoma-pancreatic-somatostatinoma-Reticulocytes-lymphoma-testicular0
C154-adenocarcinoma-Mesenchymal-Cardiac-small-sacrococcigeal-Smooth-Prostate0
C155-pituitary-placenta-nonsmall-cervical-smallcell-choriocarcinoma-epitheloid0
C156-plasma-splenic-hereditary-B-large-xeroderma-b0
C157-testicular-H9-testis-iPS-teratocarcinoma-colon-trachea0
C158-adrenal-gastric-temporal-parietal-duodenum-caudate-putamen0
C159-choriocarcinoma-pancreatic-placenta-chorionic-testicular-bronchioalveolar-seminal0
C16-medial-amygdala-occipital-parietal-olfactory-putamen-brain0
C160-medulla-Hepatocyte-retina-corpus-liver-pineal-cerebral0
C161-mesothelioma-Mesothelial-acute-mesenchymal-extraskeletal-renal-placenta0
C162-spinal-locus-medulla-substantia-thalamus-globus-diencephalon0
C163-Skeletal-skeletal-Pericytes-Hepatic-rhabdomyosarcoma-throat-mesenchymal0
C164-signet-corpus-optic-mucinous-substantia-salivary-choriocarcinoma0
C165-epithelioid-Adipocyte-mesothelioma-myxofibrosarcoma-lung-gastric-Mesothelial0
C166-Macrophage-Monocytederived-Dendritic-adipose-lymph-CD14-lung0
C167-Basophils-Mast-Eosinophils-Neutrophils-Peripheral-Whole-CD40
C168-Mast-CD14-immature-Basophils-Eosinophils-CD34-Peripheral0
C169-hereditary-adult-gall-lymphangiectasia-chronic-b-choriocarcinoma0
C17-Mast-CD14-Monocytederived-Lymphatic-Smooth-mesenchymal-Macrophage0
C170-epitheloid-cervical-Hep2-keratoacanthoma-adult-neuroblastoma-signet0
C171-merkel-neuroblastoma-pineal-retinoblastoma-carcinoid-small-eye0
C172-chorionic-skeletal-tongue-amniotic-liver-gastrointestinal-Pericytes0.164
C173-Adipocyte-mature-skin-left-Hepatocyte-Osteoblast-adipose0
C174-CD14-Neutrophils-Smooth-mesothelioma-embryonic-Monocytederived-Eosinophils0
C175-Eosinophils-Neutrophils-CD4-Basophils-CD19-CD8-Natural0
C176-Eosinophils-Neutrophils-Mast-CD14-CD4-Basophils-CD190.201
C177-melanoma-Melanocyte-mesenchymal-retina-Mallassezderived-Gingival-squamous0
C178-spleen-liver-Hepatocyte-b-lymph-vein-thymus0
C179-CD19-Peripheral-lymphoma-blood-lymph-spleen-tonsil0
C18-CD4-CD8-thymus-Whole-Peripheral-Natural-blood0
C180-skeletal-heart-Hepatocyte-acute-occipital-hippocampus-middle1.242
C181-liposarcoma-somatostatinoma-neuroblastoma-mesothelioma-nonsmall-small-Alveolar0
C182-renal-mature-mesothelioma-lung-Mammary-Adipocyte-acute0
C183-acute-non-CD34-diffuse-CD133-myeloma-Burkitt0
C184-somatostatinoma-smallcell-nonsmall-small-gastrointestinal-pineal-thyroid0
C185-small-adrenal-gastric-Mesenchymal-acute-HES3GFP-testis0
C186-squamous-papillotubular-large-Tracheal-oral-Small-epidermoid0
C187-migratory-immature-Dendritic-CD19-CD14-Monocytederived-Macrophage0.0896
C188-left-heart-tongue-skeletal-Skeletal-diaphragm-throat0.227
C189-b-splenic-tonsil-CD19-lymph-appendix-spleen0
C19-embryonic-testis-cord-chronic-CD14-NK-mesothelioma0
C190-colon-small-rectum-duodenum-appendix-temporal-oral0
C191-leiomyoblastoma-Mast-parietal-acute-bone-neuroepithelioma-embryonic0
C192-Neutrophils-CD14-Peripheral-Eosinophils-CD8-Natural-CD40.0896
C193-Mesenchymal-Adipocyte-mature-Cardiac-heart-CD14CD16-CD140
C194-MCF7-breast-prostate-Intestinal-diffuse-Wilms-Alveolar0
C195-Small-Gingival-Bronchial-Smooth-mesenchymal-Urothelial-Tracheal0
C196-testicular-iPS-H9-teratocarcinoma-HES3GFP-choriocarcinoma-endometrial0
C197-tongue-esophagus-tonsil-salivary-cervix-nasal-Gingival0
C198-Mesenchymal-Hair-Hepatic-Fibroblast-Smooth-tenocyte-Pericytes0.164
C199-glioblastoma-B-osteosarcoma-Fibroblast-heart-rhabdomyosarcoma-myxofibrosarcoma0
C2-Eosinophils-Neutrophils-CD14-Whole-Basophils-Peripheral-Mast0
C20-heart-left-skeletal-diaphragm-tongue-umbilical-throat0.797
C200-seminal-Cardiac-Smooth-Hair-submaxillary-Neutrophils-mixed0.103
C201-colon-small-adenocarcinoma-duodenum-temporal-signet-gall0
C202-salivary-skin-penis-tongue-uterus-cervical-immature0
C203-acute-NK-chronic-CD133-lymphoma-immature-Dendritic0
C204-Smooth-nasal-CD4-CD19-CD8-CD14-CD340
C205-mycosis-cord-hairy-xeroderma-CD4-B-b0
C206-melanoma-somatostatinoma-nonsmall-small-neuroblastoma-smallcell-pituitary0
C207-Corneal-Keratinocyte-Esophageal-Mammary-Bronchial-Urothelial-Sebocyte0
C208-skin-amniotic-papillotubular-salivary-umbilical-Alveolar-serous0
C209-acute-myelodysplastic-CD34-granulocyte-CD133-liver-spleen0
C21-cord-mycosis-hairy-xeroderma-adult-CD4-anaplastic0
C210-Burkitt-lymphoma-appendix-acute-diffuse-CD19-tonsil0
C211-small-Hepatocyte-liver-colon-temporal-duodenum-kidney0
C212-chronic-acute-Whole-Reticulocytes-leukemia-blood-CD340
C213-CD14-Natural-CD8-CD4-Basophils-Eosinophils-Peripheral0
C214-Neurons-Neural-duodenum-temporal-occipital-parietal-brain0
C215-chronic-acute-peripheral-Hepatocyte-osteosarcoma-NK-immature0
C216-osteosarcoma-Smooth-Mesenchymal-large-neuroectodermal-acute-CD340
C217-carcinoid-neuroectodermal-mature-mesodermal-colon-acute-occipital0
C218-tonsil-lymph-CD19-spleen-colon-appendix-salivary0
C219-nasal-Basophils-amniotic-Melanocyte-CD14-Osteoblast-duodenum0
C22-CD4-CD8-Natural-Basophils-CD14-Peripheral-CD190
C220-Adipocyte-mature-left-breast-skin-liver-adipose0.0896
C221-alveolar-Osteoblast-Myoblast-mesenchymal-liposarcoma-Smooth-hepatocellular0
C222-Melanocyte-Tracheal-Neutrophils-seminal-Smooth-Hair-Chondrocyte0.171
C223-Chondrocyte-basal-renal-Fibroblast-Smooth-spindle-Synoviocyte0
C224-clear-serous-pleomorphic-choriocarcinoma-mesothelioma-amniotic-renal0
C225-ductal-alveolar-giant-prostate-salivary-squamous-Tracheal0
C226-Corneal-Keratinocyte-Esophageal-Urothelial-Mammary-Bronchial-Tracheal0
C227-chorionic-amniotic-Mesenchymal-Placental-gastric-diaphragm-tongue0
C228-colon-Intestinal-Prostate-hepatoblastoma-hepatocellular-testis-adult0
C229-Mesenchymal-CD4-Melanocyte-acute-skeletal-left-heart0
C23-CD4-CD8-Natural-Peripheral-Basophils-CD19-CD140
C230-aorta-normal-heart-penis-osteosarcoma-basal-lung0.647
C231-Mesothelial-mesenchymal-mesothelioma-Fibroblast-Preadipocyte-leiomyoma-mycosis0
C232-teratocarcinoma-HES3GFP-H9-iPS-testicular-neuroblastoma-cerebellum0
C233-uterus-cervix-ovary-epididymis-colon-rectum-MCF70
C234-oral-epidermoid-malignant-cervical-ductal-lung-keratoacanthoma0
C235-Intestinal-Prostate-liver-colon-small-kidney-pancreas0
C236-CD14-Neutrophils-Monocytederived-renal-Eosinophils-testis-mesothelioma0
C237-acute-breast-testicular-hepatoblastoma-chronic-argyrophil-Bronchial0
C238-stomach-gall-breast-duodenum-temporal-MCF7-smallcell0
C239-CD4-lymphangiectasia-CD8-NK-mycosis-Renal-hairy0
C24-pineal-eye-retina-retinoblastoma-medulloblastoma-small-cerebral0
C240-Adipocyte-Preadipocyte-Osteoblast-Chondrocyte-tenocyte-Synoviocyte-mesenchymal0
C241-Reticulocytes-chronic-Tracheal-Hodgkin-Endothelial-Hair-thymus-0.906
C242-acute-Chondrocyte-myelodysplastic-granulocyte-biphenotypic-Fibroblast-stomach0
C243-Chondrocyte-trachea-Synoviocyte-mesodermal-renal-Fibroblast-Ewing0
C244-CD14-Monocytederived-Hepatocyte-heart-Neutrophils-acute-Macrophage0
C245-prostate-penis-salivary-esophagus-kidney-Neutrophils-Pancreatic0
C246-Neutrophils-Eosinophils-Whole-CD14-CD14CD16-Basophils-migratory0.164
C247-pons-locus-medulla-spinal-paracentral-medial-occipital0
C248-iPS-Aortic-Hep2-amygdala-acute-medial-Myoblast0
C249-nonsmall-small-smallcell-occipital-somatostatinoma-maxillary-medial0
C25-small-colon-temporal-duodenum-liver-Hepatocyte-gall0
C250-Mast-Neutrophils-CD14-Eosinophils-CD8-Peripheral-CD40.0773
C251-gall-tonsil-trachea-CD14-salivary-throat-tongue0
C252-hepatic-Olfactory-sacrococcigeal-leiomyoma-normal-Synoviocyte-glioblastoma0.164
C253-spleen-rhabdomyosarcoma-Hepatocyte-small-uterus-liver-rectum0
C254-prostate-rhabdomyosarcoma-seminal-Fibroblast-transitionalcell-Smooth-Iris0
C255-Wilms-leiomyoblastoma-kidney-adrenal-MCF7-epithelioid-Mast0
C256-occipital-caudate-amygdala-medial-thalamus-hippocampus-medulla0
C257-pineal-insula-frontal-occipital-temporal-medial-paracentral0
C258-hepatoblastoma-hepatocellular-signet-colon-Intestinal-Prostate-gastric0
C259-Preadipocyte-Adipocyte-Fibroblast-Chondrocyte-tenocyte-normal-Ewing0
C26-Eosinophils-Neutrophils-CD14-CD14CD16-Basophils-Monocytederived-Whole0
C260-acute-chronic-Natural-NK-Basophils-biphenotypic-blood0
C261-locus-medial-parietal-pons-diencephalon-olfactory-spinal0
C262-breast-MCF7-skeletal-Reticulocytes-mucinous-hepatoblastoma-Wilms0
C263-cervical-keratoacanthoma-tongue-skin-esophagus-throat-tonsil0
C264-giant-keratoacanthoma-colon-fibrosarcoma-HES3GFP-Hep2-acute0
C265-CD4-Eosinophils-CD14-Natural-CD19-Basophils-CD80
C266-acute-chronic-leukemia-small-choriocarcinoma-hepatoma-Mast0
C267-pancreatic-placenta-choriocarcinoma-testicular-teratocarcinoma-chorionic-clear0
C268-Mallassezderived-Urothelial-Gingival-Small-Bronchial-Tracheal-Prostate0
C269-Basophils-Mast-Eosinophils-mature-CD14-chorionic-CD40
C27-pancreas-temporal-duodenum-salivary-ductus-umbilical-lung0
C270-CD4-Fibroblast-acute-iPS-Aortic-CD34-Smooth-0.0133
C271-pineal-spinal-locus-globus-medulla-thalamus-cerebellum0.0896
C272-CD19-CD4-CD8-Whole-Peripheral-lymph-tonsil0
C273-Neutrophils-CD14-Eosinophils-Monocytederived-CD4-Natural-Mast0.0896
C274-CD14-Mast-immature-Basophils-mature-vagina-Hepatocyte0
C275-pons-medulla-cerebellum-locus-thalamus-diencephalon-spinal0
C276-mesothelioma-kidney-renal-small-clear-cerebellum-Renal0
C277-mesothelioma-epithelioid-thyroid-extraskeletal-alveolar-glioblastoma-adenocarcinoma0
C278-amygdala-hippocampus-insula-medial-putamen-temporal-olfactory0
C279-parietal-cerebellum-occipital-temporal-middle-duodenum-medial0
C28-thymus-acute-vein-Hodgkin-chronic-throat-Dendritic0
C280-Mast-Natural-CD19-CD8-Eosinophils-CD34-CD40
C281-Hodgkin-Reticulocytes-chronic-NK-acute-retinoblastoma-small-0.627
C282-acute-B-tonsil-CD19-submaxillary-lymph-throat0
C283-tenocyte-Chondrocyte-mesenchymal-Macrophage-pleomorphic-Synoviocyte-cholangiocellular0
C284-parietal-occipital-medial-temporal-olfactory-locus-hippocampus0.332
C285-cervical-Hep2-small-colon-temporal-duodenum-bronchogenic0
C286-cerebellum-occipital-optic-parietal-globus-caudate-medial0.6
C287-Hepatocyte-Chondrocyte-Adipocyte-Synoviocyte-liver-tenocyte-mesenchymal0
C288-Chondrocyte-Renal-Pericytes-Fibroblast-aorta-Smooth-Meningeal0.486
C289-chorionic-skeletal-heart-Mast-amniotic-granulosa-left0
C29-mature-adipose-Adipocyte-breast-Lymphatic-vein-heart0.164
C290-Eosinophils-CD14-Basophils-Mast-CD4-CD8-immature0
C291-spinal-substantia-retina-medulla-tongue-skeletal-trachea0
C292-Mesenchymal-skin-umbilical-Adipocyte-mesenchymal-Chondrocyte-skeletal0.0896
C293-CD14-CD14CD16-Basophils-Peripheral-immature-Eosinophils-CD340
C294-CD14-Macrophage-Monocytederived-CD14CD16-Neutrophils-Basophils-Peripheral0.164
C295-Fibroblast-Smooth-Myoblast-Chondrocyte-hepatic-Synoviocyte-Preadipocyte0
C296-gall-small-mesothelioma-acute-bronchioalveolar-epidermoid-mixed0
C297-Eosinophils-CD4-Basophils-Natural-Neutrophils-CD8-Peripheral0
C298-small-optic-substantia-thalamus-diencephalon-globus-occipital0
C299-CD14CD16-Eosinophils-Neutrophils-CD14-Whole-Basophils-blood0
C3-occipital-temporal-insula-medial-postcentral-frontal-amygdala0
C30-thyroid-throat-mesothelioma-mucinous-trachea-chorionic-mesenchymal0
C300-CD4-CD8-NK-Natural-blood-mycosis-Basophils0
C301-Smooth-mesenchymal-Endothelial-Hepatic-basal-hepatic-chorionic0
C302-acute-peripheral-Neutrophils-NK-myelodysplastic-CD34-carcinoid0
C303-CD14-Basophils-Peripheral-Eosinophils-CD14CD16-Neutrophils-Whole0
C305-heart-skeletal-smooth-left-bladder-penis-esophagus0.69
C31-skeletal-tongue-diaphragm-throat-penis-skin-trachea0.0896
C32-middle-occipital-parietal-hippocampus-amygdala-medial-olfactory0
C33-Reticulocytes-liver-Whole-blood-chronic-acute-spleen0
C34-placenta-chorionic-choriocarcinoma-mesothelioma-Wilms-Smooth-bile0
C35-caudate-putamen-diencephalon-nucleus-globus-thalamus-insula0
C36-B-b-splenic-plasma-xeroderma-adrenal-Burkitt0
C37-salivary-submaxillary-parotid-seminal-tongue-ductus-trachea0
C38-extraskeletal-rhabdomyosarcoma-adrenal-rectal-mesothelioma-lung-Wilms0
C39-epididymis-ductus-seminal-testis-acute-thyroid-CD1330
C4-optic-corpus-substantia-medulla-spinal-thalamus-globus0
C40-eye-retina-Lens-pineal-tongue-retinoblastoma-small0
C41-retina-eye-medulla-Retinal-medulloblastoma-kidney-pineal0
C42-small-lung-maxillary-pharyngeal-Mesenchymal-Wilms-colon0
C43-ductus-seminal-duodenum-temporal-gall-prostate-bladder0
C44-Dendritic-CD19-CD133-granulocyte-acute-thymus-immature0
C45-testicular-choriocarcinoma-H9-teratocarcinoma-Wilms-pancreatic-iPS0
C46-acute-Hodgkin-thymus-CD8-chronic-CD4-merkel0
C47-CD19-Burkitt-acute-xeroderma-tonsil-lymphoma-appendix0
C48-smooth-bladder-esophagus-colon-penis-aorta-uterus0.452
C49-H9-iPS-testicular-HES3GFP-teratocarcinoma-hepatoblastoma-choriocarcinoma0
C5-Hepatocyte-liver-hepatocellular-Intestinal-kidney-small-pancreas0
C50-chorionic-placenta-amniotic-migratory-smallcell-chronic-choriocarcinoma0
C51-kidney-mesothelioma-renal-signet-gall-lung-pancreas0
C52-adult-NK-chronic-cord-testis-embryonic-myeloma0
C53-medulloblastoma-pineal-retinoblastoma-small-retina-eye-pituitary0
C54-Dendritic-Macrophage-Monocytederived-CD14-leiomyoma-adipose-immature0
C55-hepatocellular-Intestinal-liver-Prostate-fibrosarcoma-Hepatocyte-hepatoblastoma0
C56-heart-left-umbilical-skeletal-penis-diaphragm-tongue0.452
C57-Neutrophils-Eosinophils-Whole-CD4-CD8-CD19-Natural0.0896
C58-Melanocyte-melanoma-retina-Retinal-eye-migratory-H90
C59-Smooth-Fibroblast-Mesenchymal-tenocyte-Ewing-skin-hepatic0.0896
C6-CD14-Eosinophils-Basophils-Peripheral-CD34-Natural-immature0
C60-esophagus-tonsil-throat-tongue-uterus-cervix-cervical0
C61-migratory-Dendritic-immature-Macrophage-xeroderma-cord-b0
C62-Burkitt-tonsil-CD19-submaxillary-spleen-salivary-lymph0
C63-neuroectodermal-neuroblastoma-carcinoid-peripheral-chronic-neuroepithelioma-acute0
C64-Mast-chronic-acute-immature-chorionic-Basophils-Dendritic0
C65-CD14-Eosinophils-Monocytederived-Basophils-immature-Macrophage-Neutrophils0
C66-cerebellum-middle-occipital-parietal-medial-amygdala-hippocampus0.0896
C67-CD14-Monocytederived-Macrophage-dura-Dendritic-spleen-lung0
C68-amniotic-chorionic-Placental-salivary-placenta-tongue-mesothelioma0
C69-anaplastic-CD14-cord-hairy-mycosis-adult-NK0
C7-CD14-Eosinophils-Neutrophils-Smooth-Basophils-Macrophage-Mast0
C70-parotid-submaxillary-salivary-throat-trachea-aorta-tongue0
C71-Monocytederived-Macrophage-CD14-Dendritic-Osteoblast-leiomyoma-Prostate0
C72-skeletal-tongue-throat-heart-diaphragm-penis-left0
C73-pineal-eye-retina-caudate-cerebellum-left-parietal0
C74-splenic-B-b-plasma-xeroderma-lymphoma-hairy0
C75-Eosinophils-Natural-CD8-Basophils-CD14-CD4-Peripheral0
C76-argyrophil-gastrointestinal-temporal-duodenum-neuroblastoma-merkel-smallcell0
C77-Saos2-osteosarcoma-Neutrophils-Natural-Chondrocyte-Basophils-CD80
C78-lymphoma-plasma-tonsil-appendix-lymph-seminal-trachea0
C79-chorionic-Chondrocyte-Cardiac-Smooth-Fibroblast-Preadipocyte-Mesenchymal0.0896
C8-Natural-CD8-Basophils-CD4-CD14-Peripheral-CD340
C80-immature-migratory-CD14-Dendritic-splenic-cord-Mast0
C81-trachea-salivary-throat-aorta-eye-submaxillary-parotid0
C82-Basophils-CD14-Eosinophils-Natural-Peripheral-immature-CD340
C83-choriocarcinoma-pancreatic-placenta-chorionic-HES3GFP-testicular-amniotic0
C84-choriocarcinoma-pancreatic-Wilms-Mallassezderived-thymus-salivary-colon0
C85-neuroblastoma-carcinoid-retinoblastoma-small-pineal-rhabdomyosarcoma-medulloblastoma0
C86-colon-carcinoid-small-neuroectodermal-giant-large-neuroepithelioma0
C87-retinoblastoma-left-nonsmall-heart-small-diaphragm-bronchogenic0
C88-Melanocyte-melanoma-Macrophage-Mesenchymal-migratory-Dendritic-Monocytederived0
C89-small-retinoblastoma-medulloblastoma-iPS-acantholytic-eye-bronchogenic0
C9-skeletal-diaphragm-tongue-throat-penis-heart-left0.227
C90-neuroectodermal-peripheral-neuroepithelioma-neuroblastoma-carcinoid-parietal-putamen0
C91-Fibroblast-Smooth-mesenchymal-Mesothelial-Small-Preadipocyte-Hair0
C92-CD14CD16-CD14-Eosinophils-Basophils-Neutrophils-Macrophage-Whole0
C93-chronic-acute-leukemia-acantholytic-medulloblastoma-testis-papillotubular0
C94-smallcell-adrenal-lung-nonsmall-small-somatostatinoma-teratocarcinoma0
C95-lung-aorta-trachea-penis-Alveolar-throat-endometrioid0
C96-non-acute-tonsil-spleen-Burkitt-lymphoma-appendix0
C97-small-smallcell-gastrointestinal-argyrophil-putamen-duodenum-brain0
C98-CD8-Natural-Basophils-blood-CD4-Peripheral-Whole0
C99-hairy-mycosis-submaxillary-salivary-cord-kidney-parotid0



Repeat families with enriched expression in this sample<b>Summary:</b>Ranked list of repeat family expression in this sample relative tothe median expression in the FANTOM5 collection is shown. Value is log10transformed.<br><b>Analyst:</b>NA<br><br>link to dataset.<br>data



TFBS(DNA)motifs over-represented in proximal region of promoters active in this sample


JASPAR motifs<b>Summary:</b>Association of JASPAR motif to the promoter expression in thissample. Pearson's correlation between the number of TFBSs estimated byusing the position-weight matrix for each promoter and its expression isexpressed as Z-score by taking the ones based on random position-weightmatrix, and the tail probability of the normal distribution correspondingto the Z-score is taken as the resulting P-value. Lower P-value indicatesmore (non-random) association of the motif to promoter expression<br><b>Analyst:</b> Michiel de Hoon <br><br><br>link to dataset.<br>data

library id: CNhs12856

Jaspar motifP-value
MA0002.20.00576
MA0003.10.869
MA0004.19.56141e-4
MA0006.10.804
MA0007.10.209
MA0009.10.333
MA0014.10.155
MA0017.10.608
MA0018.20.0715
MA0019.10.748
MA0024.10.00361
MA0025.10.874
MA0027.10.734
MA0028.11.53077e-7
MA0029.10.826
MA0030.10.747
MA0031.10.977
MA0035.20.413
MA0038.10.00768
MA0039.20.0378
MA0040.10.199
MA0041.10.964
MA0042.10.673
MA0043.10.0134
MA0046.10.0141
MA0047.20.597
MA0048.10.183
MA0050.10.121
MA0051.10.053
MA0052.13.92143e-32
MA0055.10.00114
MA0057.10.808
MA0058.11.19296e-4
MA0059.11.73276e-5
MA0060.14.17226e-8
MA0061.11.47252e-6
MA0062.21.56365e-14
MA0065.20.362
MA0066.10.184
MA0067.10.133
MA0068.10.879
MA0069.10.883
MA0070.10.825
MA0071.10.643
MA0072.10.395
MA0073.10.664
MA0074.10.795
MA0076.11.09282e-9
MA0077.10.917
MA0078.10.521
MA0079.20.67
MA0080.22.28277e-7
MA0081.10.0106
MA0083.13.37424e-6
MA0084.10.884
MA0087.10.888
MA0088.10.0287
MA0090.10.0117
MA0091.10.431
MA0092.10.331
MA0093.14.0146e-4
MA0099.23.29489e-28
MA0100.10.0193
MA0101.16.30421e-5
MA0102.20.0314
MA0103.10.00834
MA0104.21.84993e-5
MA0105.13.20637e-8
MA0106.10.0462
MA0107.12.1527e-6
MA0108.24.16679e-4
MA0111.10.578
MA0112.20.612
MA0113.10.102
MA0114.10.436
MA0115.10.393
MA0116.17.0597e-4
MA0117.10.403
MA0119.10.302
MA0122.10.237
MA0124.10.53
MA0125.10.717
MA0131.10.25
MA0135.10.861
MA0136.11.0032e-13
MA0137.20.631
MA0138.20.451
MA0139.10.0775
MA0140.10.821
MA0141.10.0539
MA0142.10.00451
MA0143.10.326
MA0144.10.455
MA0145.10.458
MA0146.10.138
MA0147.15.97649e-6
MA0148.10.851
MA0149.10.19
MA0150.11.11163e-7
MA0152.10.399
MA0153.10.454
MA0154.10.0886
MA0155.10.866
MA0156.19.61262e-15
MA0157.10.359
MA0159.10.54
MA0160.10.138
MA0162.10.556
MA0163.11.11942e-5
MA0164.10.488
MA0258.10.633
MA0259.10.0237



FANTOM5 phase1 novel unique motifs<b>Summary:</b>Association of the 169 novel and unique motifs discovered in FANTOM5 phase1 in this sample. Among the de-novo motifs discovered by DMF, HOMER,ChIPMunk, and ScanAll, only novel motifs are selected after comparison with known motif sets, and their clustering based on MACRO-APE resulted in169 novel and unique motifs. Their association to the promoter expression is evaluated in the same way to the JASPAR motif above<br><b>Analyst:</b> Michiel de Hoon <br><br><br>link to dataset.<br>data

library id: CNhs12856

Novel motifP-value
10.17
100.126
1000.514
1010.246
1020.269
1030.115
1040.098
1050.775
1060.596
1070.487
1080.42
1090.00622
110.072
1100.143
1110.293
1120.826
1130.245
1140.58
1150.724
1160.564
1170.00823
1180.0121
1190.385
120.627
1200.13
1210.424
1220.0343
1230.927
1240.626
1250.566
1260.403
1270.539
1280.459
1290.64
130.119
1300.421
1310.216
1320.0188
1330.298
1340.346
1350.247
1362.99251e-4
1370.441
1380.693
1390.629
140.762
1400.602
1410.919
1420.851
1430.0171
1440.511
1450.359
1460.266
1470.0271
1480.848
1490.377
150.17
1500.362
1510.999
1520.503
1530.126
1540.766
1550.413
1560.831
1570.42
1580.395
1590.142
160.116
1600.865
1610.688
1620.898
1630.377
1640.0597
1650.465
1660.0563
1670.213
1680.823
1690.232
170.402
180.0668
190.289
20.203
200.0664
210.606
220.901
230.428
240.0462
250.258
260.0157
270.39
280.638
291.2163e-4
30.146
300.247
310.894
320.364
330.0469
340.275
350.671
360.0581
370.207
380.542
390.313
40.685
400.0127
410.15
420.213
430.13
440.499
450.48
460.319
470.0888
480.0817
490.736
50.552
500.977
510.424
520.274
530.832
540.727
550.729
560.556
570.298
580.477
590.503
60.962
600.984
610.0742
620.467
630.614
640.146
650.982
664.26348e-4
670.564
680.187
690.62
70.36
700.131
710.0187
720.456
730.0611
740.473
750.0182
760.112
770.62
780.509
790.381
80.251
800.526
810.891
820.416
830.206
840.439
850.2
860.696
872.34822e-6
880.984
890.486
90.857
900.0919
910.0684
920.653
930.713
940.109
952.53242e-4
960.389
970.809
980.748
990.256



de novo motifs identified by HOMER in promoters active in this sample<b>Summary:</b>The result of HOMER in this sample is shown.<br><b>Analyst:</b>NA <br> library id: CNhs12856


FANTOM5 (FF) ontology


Direct parent terms


Ancestor terms (non development)<b>Summary:</b>Connected ontology terms with is_a, part_of or located_in relationship <br><b>Analyst:</b> Hideya Kawaji<br><br>link to source data<br>data

UBERON: Anatomy
0000468 (multi-cellular organism)
0007023 (adult organism)
0007100 (primary circulatory organ)
0000948 (heart)
0002146 (pulmonary valve)
0000479 (tissue)
0004121 (ectoderm-derived structure)
0000064 (organ part)
0010314 (structure with developmental contribution from neural crest)
0000062 (organ)
0004120 (mesoderm-derived structure)
0000061 (anatomical structure)
0000465 (material anatomical entity)
0000467 (anatomical system)
0010313 (neural crest-derived structure)
0001062 (anatomical entity)
0000480 (anatomical group)
0003103 (compound organ)
0003978 (valve)
0000946 (cardial valve)
0005623 (semi-lunar valve)
0010317 (germ layer / neural crest derived structure)
0004535 (cardiovascular system)
0001009 (circulatory system)

FF: FANTOM5
0000102 (sample by type)
0000210 (human sample)
0000101 (sample by species)
0000001 (sample)
0000998 (adult tissue sample)
0000004 (tissue sample)
0010206 (human heart, pulmonic valve - adult sample)

Ancestor terms (development)<b>Summary:</b>Connected ontology terms with develops_from, derives_from or preceded_by relationship <br><b>Analyst:</b> Hideya Kawaji <br><br>link to source data<br>data
UBERON:0002532 (epiblast (generic))
UBERON:0006601 (presumptive ectoderm)
UBERON:0006603 (presumptive mesoderm)
UBERON:0003104 (mesenchyme)
UBERON:0005062 (neural fold)
UBERON:0007284 (presumptive neural plate)
UBERON:0010316 (germ layer / neural crest)