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Coexpression cluster:C107

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Full id: C107_Neutrophils_CD14_Eosinophils_Monocytederived_Whole_Peripheral_blood



Phase1 CAGE Peaks

Hg19::chr10:30725492..30725508,+p1@ENST00000517117
Hg19::chr10:36812448..36812461,+p@chr10:36812448..36812461
+
Hg19::chr10:6268163..6268176,+p@chr10:6268163..6268176
+
Hg19::chr10:70856882..70856896,+p8@SRGN
Hg19::chr10:70863664..70863702,+p@chr10:70863664..70863702
+
Hg19::chr10:70863704..70863715,+p@chr10:70863704..70863715
+
Hg19::chr10:70863827..70863945,+p@chr10:70863827..70863945
+
Hg19::chr10:70863991..70864065,+p@chr10:70863991..70864065
+
Hg19::chr10:70864200..70864224,+p@chr10:70864200..70864224
+
Hg19::chr10:70864321..70864461,+p@chr10:70864321..70864461
+
Hg19::chr10:70864499..70864516,+p@chr10:70864499..70864516
+
Hg19::chr10:81036951..81036975,+p9@ZMIZ1
Hg19::chr10:98411359..98411370,-p@chr10:98411359..98411370
-
Hg19::chr11:47402161..47402172,-p@chr11:47402161..47402172
-
Hg19::chr11:64627800..64627813,-p14@EHD1
Hg19::chr11:73111863..73111868,+p@chr11:73111863..73111868
+
Hg19::chr11:9189018..9189023,-p@chr11:9189018..9189023
-
Hg19::chr12:104689289..104689304,+p@chr12:104689289..104689304
+
Hg19::chr12:11941706..11941715,+p@chr12:11941706..11941715
+
Hg19::chr12:7069526..7069543,+p@chr12:7069526..7069543
+
Hg19::chr13:41556186..41556208,-p12@ELF1
Hg19::chr13:49106957..49106986,+p4@RCBTB2
Hg19::chr14:103602898..103602915,+p@chr14:103602898..103602915
+
Hg19::chr14:35871083..35871094,-p@chr14:35871083..35871094
-
Hg19::chr14:35871193..35871245,-p@chr14:35871193..35871245
-
Hg19::chr14:35871248..35871275,-p@chr14:35871248..35871275
-
Hg19::chr14:35871743..35871762,-p@chr14:35871743..35871762
-
Hg19::chr15:58465371..58465381,+p@chr15:58465371..58465381
+
Hg19::chr15:58468831..58468835,+p@chr15:58468831..58468835
+
Hg19::chr15:58476142..58476157,+p@chr15:58476142..58476157
+
Hg19::chr15:58476191..58476232,+p@chr15:58476191..58476232
+
Hg19::chr15:58476291..58476309,+p@chr15:58476291..58476309
+
Hg19::chr15:58476386..58476397,+p@chr15:58476386..58476397
+
Hg19::chr15:58476413..58476430,+p@chr15:58476413..58476430
+
Hg19::chr15:58476515..58476543,+p@chr15:58476515..58476543
+
Hg19::chr15:89185184..89185187,+p@chr15:89185184..89185187
+
Hg19::chr16:11650476..11650513,-p7@LITAF
Hg19::chr16:3109599..3109646,+p@chr16:3109599..3109646
+
Hg19::chr16:31370061..31370065,+p@chr16:31370061..31370065
+
Hg19::chr16:31885632..31885657,+p@chr16:31885632..31885657
+
Hg19::chr16:31896481..31896487,+p@chr16:31896481..31896487
+
Hg19::chr16:31898587..31898590,+p@chr16:31898587..31898590
+
Hg19::chr16:31920466..31920469,+p@chr16:31920466..31920469
+
Hg19::chr16:3304314..3304318,-p@chr16:3304314..3304318
-
Hg19::chr16:50706888..50706902,-p@chr16:50706888..50706902
-
Hg19::chr17:1494137..1494149,-p@chr17:1494137..1494149
-
Hg19::chr17:38512930..38512974,+p@chr17:38512930..38512974
+
Hg19::chr17:43311522..43311537,+p17@FMNL1
Hg19::chr17:4618707..4618720,+p@chr17:4618707..4618720
+
Hg19::chr17:76353696..76353712,-p@chr17:76353696..76353712
-
Hg19::chr17:7749388..7749406,+p@chr17:7749388..7749406
+
Hg19::chr17:7751578..7751597,+p@chr17:7751578..7751597
+
Hg19::chr17:7752039..7752051,+p@chr17:7752039..7752051
+
Hg19::chr17:7757204..7757221,+p@chr17:7757204..7757221
+
Hg19::chr17:7757248..7757259,+p@chr17:7757248..7757259
+
Hg19::chr17:8124719..8124737,+p@chr17:8124719..8124737
+
Hg19::chr17:8783579..8783617,-p@chr17:8783579..8783617
-
Hg19::chr17:8785005..8785013,-p@chr17:8785005..8785013
-
Hg19::chr19:10385439..10385500,+p1@M55024
Hg19::chr19:10394236..10394259,+p@chr19:10394236..10394259
+
Hg19::chr19:10394909..10394927,+p6@ICAM1
Hg19::chr19:10395834..10395869,+p2@ICAM1
Hg19::chr19:45254481..45254495,+p13@BCL3
Hg19::chr19:45254529..45254561,+p10@BCL3
Hg19::chr19:45257744..45257775,-p@chr19:45257744..45257775
-
Hg19::chr19:46021273..46021287,+p@chr19:46021273..46021287
+
Hg19::chr19:47823066..47823077,+p6@C5AR1
Hg19::chr19:47823108..47823121,+p4@C5AR1
Hg19::chr19:47823947..47823977,+p@chr19:47823947..47823977
+
Hg19::chr19:6911416..6911419,+p@chr19:6911416..6911419
+
Hg19::chr1:111415920..111415938,+p@chr1:111415920..111415938
+
Hg19::chr1:12233986..12233997,+p@chr1:12233986..12233997
+
Hg19::chr1:12268070..12268096,+p@chr1:12268070..12268096
+
Hg19::chr1:153346989..153347005,-p2@S100A12
Hg19::chr1:159047229..159047256,+p@chr1:159047229..159047256
+
Hg19::chr1:183534904..183534917,-p@chr1:183534904..183534917
-
Hg19::chr1:186643827..186643840,-p@chr1:186643827..186643840
-
Hg19::chr1:186644510..186644524,-p5@PTGS2
Hg19::chr1:186645709..186645759,-p@chr1:186645709..186645759
-
Hg19::chr1:186646037..186646054,-p@chr1:186646037..186646054
-
Hg19::chr1:186647433..186647479,-p@chr1:186647433..186647479
-
Hg19::chr1:186648493..186648522,-p2@PTGS2
Hg19::chr1:198668673..198668721,+p@chr1:198668673..198668721
+
Hg19::chr1:204379602..204379617,-p7@PPP1R15B
Hg19::chr1:28477178..28477206,-p9@PTAFR
Hg19::chr1:31210518..31210532,-p@chr1:31210518..31210532
-
Hg19::chr1:33407895..33407908,-p@chr1:33407895..33407908
-
Hg19::chr1:45274037..45274057,+p10@BTBD19
Hg19::chr20:30655354..30655358,+p@chr20:30655354..30655358
+
Hg19::chr20:48273183..48273197,-p@chr20:48273183..48273197
-
Hg19::chr20:48807587..48807603,+p16@CEBPB
Hg19::chr20:48808321..48808329,+p18@CEBPB
Hg19::chr21:30693983..30693995,+p@chr21:30693983..30693995
+
Hg19::chr22:37271760..37271775,+p@chr22:37271760..37271775
+
Hg19::chr22:39353724..39353729,+p3@APOBEC3A
Hg19::chr22:39354248..39354259,+p@chr22:39354248..39354259
+
Hg19::chr22:50967529..50967543,-p@chr22:50967529..50967543
-
Hg19::chr2:162042013..162042017,+p@chr2:162042013..162042017
+
Hg19::chr2:178104674..178104678,-p@chr2:178104674..178104678
-
Hg19::chr2:178108722..178108726,-p@chr2:178108722..178108726
-
Hg19::chr2:191878162..191878168,-p@chr2:191878162..191878168
-
Hg19::chr2:201992511..201992523,+p@chr2:201992511..201992523
+
Hg19::chr2:201994909..201994915,+p@chr2:201994909..201994915
+
Hg19::chr2:219252609..219252626,+p@chr2:219252609..219252626
+
Hg19::chr2:219260100..219260114,+p@chr2:219260100..219260114
+
Hg19::chr2:238671981..238671993,+p@chr2:238671981..238671993
+
Hg19::chr2:68598937..68598940,+p@chr2:68598937..68598940
+
Hg19::chr2:68607457..68607467,+p@chr2:68607457..68607467
+
Hg19::chr2:68613716..68613733,+p@chr2:68613716..68613733
+
Hg19::chr2:68620333..68620347,+p@chr2:68620333..68620347
+
Hg19::chr2:68621234..68621246,+p@chr2:68621234..68621246
+
Hg19::chr2:70167296..70167306,+p3@MXD1
Hg19::chr2:7028589..7028594,+p@chr2:7028589..7028594
+
Hg19::chr3:101572086..101572118,+p@chr3:101572086..101572118
+
Hg19::chr3:146260094..146260114,-p@chr3:146260094..146260114
-
Hg19::chr3:149534318..149534320,+p@chr3:149534318..149534320
+
Hg19::chr3:149581826..149581830,+p@chr3:149581826..149581830
+
Hg19::chr3:32525474..32525488,-p2@CMTM6
Hg19::chr4:160170453..160170457,+p@chr4:160170453..160170457
+
Hg19::chr4:185697770..185697782,-p@chr4:185697770..185697782
-
Hg19::chr4:2828548..2828556,+p9@SH3BP2
Hg19::chr4:3043632..3043648,+p@chr4:3043632..3043648
+
Hg19::chr4:74608160..74608175,+p@chr4:74608160..74608175
+
Hg19::chr4:74608483..74608501,+p9@IL8
Hg19::chr5:131644103..131644105,+p@chr5:131644103..131644105
+
Hg19::chr5:131675781..131675785,+p@chr5:131675781..131675785
+
Hg19::chr5:131819320..131819333,-p@chr5:131819320..131819333
-
Hg19::chr5:131822767..131822784,-p@chr5:131822767..131822784
-
Hg19::chr5:131823700..131823718,-p@chr5:131823700..131823718
-
Hg19::chr5:131825168..131825179,-p4@IRF1
Hg19::chr5:169679481..169679500,-p@chr5:169679481..169679500
-
Hg19::chr5:169680174..169680190,-p@chr5:169680174..169680190
-
Hg19::chr5:169689728..169689741,-p@chr5:169689728..169689741
-
Hg19::chr5:169693806..169693817,+p@chr5:169693806..169693817
+
Hg19::chr5:169693846..169693873,-p@chr5:169693846..169693873
-
Hg19::chr5:169693893..169693904,-p@chr5:169693893..169693904
-
Hg19::chr5:169694054..169694090,-p5@LCP2
Hg19::chr5:169695413..169695438,-p7@LCP2
Hg19::chr5:169701329..169701349,-p@chr5:169701329..169701349
-
Hg19::chr5:90603345..90603360,-p@chr5:90603345..90603360
-
Hg19::chr5:90605182..90605197,-p@chr5:90605182..90605197
-
Hg19::chr6:12115609..12115614,+p@chr6:12115609..12115614
+
Hg19::chr6:143095902..143095910,-p3@HIVEP2
Hg19::chr6:144508935..144508960,+p3@STX11
Hg19::chr6:144509089..144509105,+p6@STX11
Hg19::chr6:160100700..160100748,-p1@AK093984
Hg19::chr6:160101116..160101129,-p17@SOD2
Hg19::chr6:160101253..160101264,-p38@SOD2
Hg19::chr6:160101278..160101296,-p25@SOD2
Hg19::chr6:160101445..160101456,-p30@SOD2
Hg19::chr6:160101463..160101476,-p24@SOD2
Hg19::chr6:160101477..160101493,-p19@SOD2
Hg19::chr6:160101566..160101580,-p26@SOD2
Hg19::chr6:160101697..160101724,-p10@SOD2
Hg19::chr6:160102949..160102962,-p@chr6:160102949..160102962
-
Hg19::chr6:160103116..160103127,-p@chr6:160103116..160103127
-
Hg19::chr6:160103198..160103229,-p@chr6:160103198..160103229
-
Hg19::chr6:160103444..160103546,-p@chr6:160103444..160103546
-
Hg19::chr6:160103586..160103607,-p@chr6:160103586..160103607
-
Hg19::chr6:160103621..160103639,+p@chr6:160103621..160103639
+
Hg19::chr6:160109951..160109968,-p@chr6:160109951..160109968
-
Hg19::chr6:32806116..32806132,+p@chr6:32806116..32806132
+
Hg19::chr6:41248877..41248896,-p@chr6:41248877..41248896
-
Hg19::chr6:89793486..89793557,+p3@PNRC1
Hg19::chr7:105986788..105986793,+p@chr7:105986788..105986793
+
Hg19::chr7:141731853..141731857,+p@chr7:141731853..141731857
+
Hg19::chr7:99972030..99972041,+p6@PILRA
Hg19::chr8:104007596..104007601,+p@chr8:104007596..104007601
+
Hg19::chr8:126442977..126442989,+p17@TRIB1
Hg19::chr8:126448604..126448616,+p25@TRIB1
Hg19::chr9:115925098..115925110,+p@chr9:115925098..115925110
+
Hg19::chr9:120470472..120470490,+p9@TLR4
Hg19::chr9:36141830..36141837,+p@chr9:36141830..36141837
+
Hg19::chr9:95884266..95884282,-p@chr9:95884266..95884282
-
Hg19::chrX:129203655..129203659,-p@chrX:129203655..129203659
-
Hg19::chrX:23801881..23801897,+p@chrX:23801881..23801897
+
Hg19::chrX:23801993..23802015,+p@chrX:23801993..23802015
+
Hg19::chrX:30726530..30726536,+p@chrX:30726530..30726536
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

p.valueFDRnGenesnPathwayName
0.0003992840277158070.01404148830800593137Natural killer cell mediated cytotoxicity (KEGG):04650
2.10806633184702e-050.00190629426865595351Malaria (KEGG):05144
2.7961012221032e-050.00221241509198916356Staphylococcus aureus infection (KEGG):05150
0.0008275710500377490.02757118287757343176Influenza A (KEGG):05164
0.0001234808479326840.00601256744164529392Rheumatoid arthritis (KEGG):05323
3.61744606966908e-050.00254427040233392361Selenium Pathway (Wikipathways):WP15
0.001370255892973750.039488154037708252Vitamin B12 Metabolism (Wikipathways):WP1533
0.0001580985561453120.006671759069332193100Senescence and Autophagy (Wikipathways):WP615
0.001267537768407280.039488154037708250Type II interferon signaling (IFNG) (Wikipathways):WP619
0.0003661130298261680.01363232634588033133T Cell Receptor Signaling Pathway (Wikipathways):WP69
1.31693457438319e-050.001389365975974276511Signaling in Immune system (Reactome):REACT_6900
0.001372416096097280.0394881540377084466Hemostasis (Reactome):REACT_604
0.000176823536539310.006995581164336466816TGF beta receptor up reg. targets (Netpath):NetPath_7
6.13226721795312e-079.70431287241081e-058728TNF alpha/NF-kB up reg. targets (Netpath):NetPath_9
5.64966556451738e-079.70431287241081e-055155IL-1 up reg. targets (Netpath):NetPath_13
8.17819163062055e-050.004313996085152345433IL-2 up reg. targets (Netpath):NetPath_14
1.31367905060236e-050.001389365975974275295IL-2 down reg. targets (Netpath):NetPath_14
7.62220659880978e-050.004313996085152344217IL-4 up reg. targets (Netpath):NetPath_16
4.63242987303954e-102.93232810963403e-07690IL-4 down reg. targets (Netpath):NetPath_16
2.44960860146816e-077.75301122364673e-055131IL-5 up reg. targets (Netpath):NetPath_17
8.14764635786901e-050.00431399608515234380IL-6 up reg. targets (Netpath):NetPath_18
0.001643897210316910.0452429101795916257IL-7 up reg. targets (Netpath):NetPath_19
0.0001437880991663430.00650127619802109217{RARA,17} (Static Module):NA



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0001816cytokine production2.2290398649873e-11
GO:0006952defense response5.433798875121e-06
GO:0009605response to external stimulus6.7497786026716e-06
GO:0006954inflammatory response1.96328965111205e-05
GO:0042035regulation of cytokine biosynthetic process2.0964285662949e-05
GO:0065007biological regulation2.0964285662949e-05
GO:0005515protein binding2.0964285662949e-05
GO:0042089cytokine biosynthetic process2.0964285662949e-05
GO:0042107cytokine metabolic process2.0964285662949e-05
GO:0042221response to chemical stimulus2.55364701945347e-05
GO:0009611response to wounding6.35925373718454e-05
GO:0002274myeloid leukocyte activation7.85130404390194e-05
GO:0045084positive regulation of interleukin-12 biosynthetic process9.83625055051188e-05
GO:0048519negative regulation of biological process0.000142006681156699
GO:0050789regulation of biological process0.000142006681156699
GO:0006955immune response0.000142006681156699
GO:0045075regulation of interleukin-12 biosynthetic process0.000142006681156699
GO:0042090interleukin-12 biosynthetic process0.000142006681156699
GO:0006950response to stress0.000153439360301109
GO:0042108positive regulation of cytokine biosynthetic process0.000170360441221724
GO:0042330taxis0.000173301283204169
GO:0006935chemotaxis0.000173301283204169
GO:0032615interleukin-12 production0.000277555723537233
GO:0031325positive regulation of cellular metabolic process0.000278623758926738
GO:0002376immune system process0.000278623758926738
GO:0045727positive regulation of translation0.000278623758926738
GO:0006366transcription from RNA polymerase II promoter0.000278623758926738
GO:0045321leukocyte activation0.000324159245032858
GO:0007626locomotory behavior0.000324159245032858
GO:0006417regulation of translation0.000326708765467945
GO:0009893positive regulation of metabolic process0.000326708765467945
GO:0031328positive regulation of cellular biosynthetic process0.000338234990026411
GO:0031326regulation of cellular biosynthetic process0.000413274490095933
GO:0032501multicellular organismal process0.000414243486747844
GO:0006357regulation of transcription from RNA polymerase II promoter0.000421937304622257
GO:0001775cell activation0.000458987569102588
GO:0009891positive regulation of biosynthetic process0.000465367139162871
GO:0009889regulation of biosynthetic process0.000492523719130039
GO:0048523negative regulation of cellular process0.000492523719130039
GO:0042088T-helper 1 type immune response0.000700069451730291
GO:0051247positive regulation of protein metabolic process0.000751520218800036
GO:0050794regulation of cellular process0.000814844471591072
GO:0045941positive regulation of transcription0.00118150492484849
GO:0045935positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.00132280558750138
GO:0007610behavior0.00138184988058552
GO:0048522positive regulation of cellular process0.00151586155017615
GO:0009620response to fungus0.00153817121316647
GO:0050663cytokine secretion0.00167262002127017
GO:0010468regulation of gene expression0.00169125801383065
GO:0031323regulation of cellular metabolic process0.00209283920943127
GO:0048518positive regulation of biological process0.00245247638102661
GO:0045944positive regulation of transcription from RNA polymerase II promoter0.00255052842973593
GO:0045185maintenance of protein localization0.00258323322401245
GO:0006355regulation of transcription, DNA-dependent0.00260130132644168
GO:0019222regulation of metabolic process0.00303547485230157
GO:0006351transcription, DNA-dependent0.00303547485230157
GO:0032774RNA biosynthetic process0.00303547485230157
GO:0048513organ development0.00317548114244536
GO:0051246regulation of protein metabolic process0.00418751893043749
GO:0045449regulation of transcription0.0046738062421673
GO:0019219regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.00523251555619257
GO:0001817regulation of cytokine production0.00544137798478529
GO:0051235maintenance of localization0.00544137798478529
GO:0006350transcription0.0057694572000471
GO:0006915apoptosis0.0057694572000471
GO:0012501programmed cell death0.0057694572000471
GO:0051707response to other organism0.0057694572000471
GO:0010467gene expression0.0057694572000471
GO:0008219cell death0.0057694572000471
GO:0016265death0.0057694572000471
GO:0045893positive regulation of transcription, DNA-dependent0.0057694572000471
GO:0033371T cell secretory granule organization and biogenesis0.0057694572000471
GO:0033377maintenance of protein localization in T cell secretory granule0.0057694572000471
GO:0033365protein localization in organelle0.0057694572000471
GO:0033370maintenance of protein localization in mast cell secretory granule0.0057694572000471
GO:0002335mature B cell differentiation0.0057694572000471
GO:0033367protein localization in mast cell secretory granule0.0057694572000471
GO:0033366protein localization in secretory granule0.0057694572000471
GO:0002312B cell activation during immune response0.0057694572000471
GO:0016046detection of fungus0.0057694572000471
GO:0033382maintenance of granzyme B localization in T cell secretory granule0.0057694572000471
GO:0033373maintenance of protease localization in mast cell secretory granule0.0057694572000471
GO:0033380granzyme B localization in T cell secretory granule0.0057694572000471
GO:0033379maintenance of protease localization in T cell secretory granule0.0057694572000471
GO:0032996Bcl3-Bcl10 complex0.0057694572000471
GO:0033364mast cell secretory granule organization and biogenesis0.0057694572000471
GO:0008383manganese superoxide dismutase activity0.0057694572000471
GO:0033368protease localization in mast cell secretory granule0.0057694572000471
GO:0002313mature B cell differentiation during immune response0.0057694572000471
GO:0019371cyclooxygenase pathway0.0057694572000471
GO:0033374protein localization in T cell secretory granule0.0057694572000471
GO:0033375protease localization in T cell secretory granule0.0057694572000471
GO:0002315marginal zone B cell differentiation0.0057694572000471
GO:0043066negative regulation of apoptosis0.00590418382699472
GO:0043069negative regulation of programmed cell death0.00606776012889687
GO:0009306protein secretion0.00689378387994926
GO:0032502developmental process0.00702996740489555
GO:0016070RNA metabolic process0.00795523672046586
GO:0030155regulation of cell adhesion0.00894330730733729
GO:0019932second-messenger-mediated signaling0.00894749628732592
GO:0002268follicular dendritic cell differentiation0.00971286054594151
GO:0033257Bcl3/NF-kappaB2 complex0.00971286054594151
GO:0042629mast cell granule0.00971286054594151
GO:0033363secretory granule organization and biogenesis0.00971286054594151
GO:0046696lipopolysaccharide receptor complex0.00971286054594151
GO:0033256I-kappaB/NF-kappaB complex0.00971286054594151
GO:0002266follicular dendritic cell activation0.00971286054594151
GO:0005153interleukin-8 receptor binding0.00971286054594151
GO:0001315age-dependent response to reactive oxygen species0.00971286054594151
GO:0045415negative regulation of interleukin-8 biosynthetic process0.00971286054594151
GO:0007165signal transduction0.00971286054594151
GO:0048731system development0.00982317753055583
GO:0009607response to biotic stimulus0.00982317753055583
GO:0002460adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.0101775419916928
GO:0002250adaptive immune response0.0101775419916928
GO:0051649establishment of cellular localization0.0103766203444414
GO:0051641cellular localization0.0114864701962215
GO:0007275multicellular organismal development0.0118899996931101
GO:0050858negative regulation of antigen receptor-mediated signaling pathway0.0124682133320994
GO:0045082positive regulation of interleukin-10 biosynthetic process0.0124682133320994
GO:0004944C5a anaphylatoxin receptor activity0.0124682133320994
GO:0010225response to UV-C0.0124682133320994
GO:0001530lipopolysaccharide binding0.0124682133320994
GO:0004666prostaglandin-endoperoxide synthase activity0.0124682133320994
GO:0050860negative regulation of T cell receptor signaling pathway0.0124682133320994
GO:0042091interleukin-10 biosynthetic process0.0124682133320994
GO:0019730antimicrobial humoral response0.0124682133320994
GO:0045074regulation of interleukin-10 biosynthetic process0.0124682133320994
GO:0042536negative regulation of tumor necrosis factor biosynthetic process0.0124682133320994
GO:0002521leukocyte differentiation0.0125621045497277
GO:0051704multi-organism process0.012643356332854
GO:0030674protein binding, bridging0.012643356332854
GO:0043405regulation of MAP kinase activity0.013095735842446
GO:0042742defense response to bacterium0.0135523882118116
GO:0008283cell proliferation0.0141965606161204
GO:0048869cellular developmental process0.0141965606161204
GO:0030154cell differentiation0.0141965606161204
GO:0007154cell communication0.0141965606161204
GO:0048468cell development0.0141965606161204
GO:0005087Ran guanyl-nucleotide exchange factor activity0.0141965606161204
GO:0002467germinal center formation0.0141965606161204
GO:0045091regulation of retroviral genome replication0.0141965606161204
GO:0019369arachidonic acid metabolic process0.0141965606161204
GO:0004942anaphylatoxin receptor activity0.0141965606161204
GO:0001892embryonic placenta development0.0141965606161204
GO:0004992platelet activating factor receptor activity0.0141965606161204
GO:0000303response to superoxide0.0141965606161204
GO:0042832defense response to protozoan0.0141965606161204
GO:0050710negative regulation of cytokine secretion0.0141965606161204
GO:0030502negative regulation of bone mineralization0.0141965606161204
GO:0048536spleen development0.0141965606161204
GO:0009617response to bacterium0.0148078715922745
GO:0007243protein kinase cascade0.0152684925342779
GO:0005737cytoplasm0.0163191090114548
GO:0042640anagen0.016636871488105
GO:0051457maintenance of protein localization in nucleus0.016636871488105
GO:0045064T-helper 2 cell differentiation0.016636871488105
GO:0032613interleukin-10 production0.016636871488105
GO:0001562response to protozoan0.016636871488105
GO:0032729positive regulation of interferon-gamma production0.016636871488105
GO:0000305response to oxygen radical0.016636871488105
GO:0006979response to oxidative stress0.0176996877048507
GO:0007242intracellular signaling cascade0.0185885031211321
GO:0032649regulation of interferon-gamma production0.0191248024712713
GO:0050709negative regulation of protein secretion0.0191248024712713
GO:0045090retroviral genome replication0.0191248024712713
GO:0042119neutrophil activation0.0191248024712713
GO:0050856regulation of T cell receptor signaling pathway0.0191248024712713
GO:0048015phosphoinositide-mediated signaling0.0195290363614825
GO:0048856anatomical structure development0.0196642202669524
GO:0048820hair follicle maturation0.0217847238095414
GO:0045671negative regulation of osteoclast differentiation0.0217847238095414
GO:0007249I-kappaB kinase/NF-kappaB cascade0.0220501452142255
GO:0045184establishment of protein localization0.0236494678176184
GO:0045414regulation of interleukin-8 biosynthetic process0.0236494678176184
GO:0030279negative regulation of ossification0.0236494678176184
GO:0045576mast cell activation0.0236494678176184
GO:0042771DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis0.0236494678176184
GO:0042534regulation of tumor necrosis factor biosynthetic process0.0236494678176184
GO:0042533tumor necrosis factor biosynthetic process0.0236494678176184
GO:0050930induction of positive chemotaxis0.0236494678176184
GO:0043231intracellular membrane-bound organelle0.0254693686739627
GO:0043227membrane-bound organelle0.0254693686739627
GO:0045670regulation of osteoclast differentiation0.0254693686739627
GO:0042116macrophage activation0.0254693686739627
GO:0042228interleukin-8 biosynthetic process0.0254693686739627
GO:0002762negative regulation of myeloid leukocyte differentiation0.0254693686739627
GO:0016721oxidoreductase activity, acting on superoxide radicals as acceptor0.0254693686739627
GO:0004784superoxide dismutase activity0.0254693686739627
GO:0008104protein localization0.0257040568900661
GO:0030097hemopoiesis0.0257040568900661
GO:0044424intracellular part0.0257040568900661
GO:0050926regulation of positive chemotaxis0.0257040568900661
GO:0045408regulation of interleukin-6 biosynthetic process0.0257040568900661
GO:0001516prostaglandin biosynthetic process0.0257040568900661
GO:0002286T cell activation during immune response0.0257040568900661
GO:0050854regulation of antigen receptor-mediated signaling pathway0.0257040568900661
GO:0046457prostanoid biosynthetic process0.0257040568900661
GO:0002292T cell differentiation during immune response0.0257040568900661
GO:0002293alpha-beta T cell differentiation during immune response0.0257040568900661
GO:0002263cell activation during immune response0.0257040568900661
GO:0002294CD4-positive, alpha-beta T cell differentiation during immune response0.0257040568900661
GO:0042092T-helper 2 type immune response0.0257040568900661
GO:0042093T-helper cell differentiation0.0257040568900661
GO:0002366leukocyte activation during immune response0.0257040568900661
GO:0002285lymphocyte activation during immune response0.0257040568900661
GO:0050927positive regulation of positive chemotaxis0.0257040568900661
GO:0050918positive chemotaxis0.0257040568900661
GO:0048534hemopoietic or lymphoid organ development0.0272051820618708
GO:0050921positive regulation of chemotaxis0.0272051820618708
GO:0051101regulation of DNA binding0.0272051820618708
GO:0043367CD4-positive, alpha beta T cell differentiation0.0272051820618708
GO:0046851negative regulation of bone remodeling0.0272051820618708
GO:0030316osteoclast differentiation0.0272051820618708
GO:0032637interleukin-8 production0.0272051820618708
GO:0030500regulation of bone mineralization0.0272051820618708
GO:0033036macromolecule localization0.0272051820618708
GO:0005615extracellular space0.027363362714516
GO:0002520immune system development0.0283656632143117
GO:0050920regulation of chemotaxis0.0283656632143117
GO:0042348NF-kappaB import into nucleus0.0283656632143117
GO:0042226interleukin-6 biosynthetic process0.0283656632143117
GO:0030593neutrophil chemotaxis0.0283656632143117
GO:0051605protein maturation via proteolysis0.0283656632143117
GO:0042345regulation of NF-kappaB import into nucleus0.0283656632143117
GO:0050832defense response to fungus0.0283656632143117
GO:0001836release of cytochrome c from mitochondria0.0303148621582159
GO:0032640tumor necrosis factor production0.0303148621582159
GO:0045069regulation of viral genome replication0.0303148621582159
GO:0042981regulation of apoptosis0.0319019423321378
GO:0051604protein maturation0.0322118294305836
GO:0009595detection of biotic stimulus0.0322118294305836
GO:0043067regulation of programmed cell death0.032391407482829
GO:0005764lysosome0.0331077455322376
GO:0000323lytic vacuole0.0332796856566326
GO:0032635interleukin-6 production0.0336292571048591
GO:0001890placenta development0.0336292571048591
GO:0002761regulation of myeloid leukocyte differentiation0.0336292571048591
GO:0030330DNA damage response, signal transduction by p53 class mediator0.034832489986551
GO:0050707regulation of cytokine secretion0.034832489986551
GO:0046632alpha-beta T cell differentiation0.034832489986551
GO:0042036negative regulation of cytokine biosynthetic process0.034832489986551
GO:0007202phospholipase C activation0.034832489986551
GO:0016050vesicle organization and biogenesis0.034832489986551
GO:0045444fat cell differentiation0.034832489986551
GO:0006917induction of apoptosis0.0348486356483192
GO:0012502induction of programmed cell death0.0350188135331035
GO:0016564transcription repressor activity0.0351888414433236
GO:0050792regulation of viral reproduction0.0356839973157255
GO:0050852T cell receptor signaling pathway0.0356839973157255
GO:0006692prostanoid metabolic process0.0356839973157255
GO:0031901early endosome membrane0.0356839973157255
GO:0051048negative regulation of secretion0.0356839973157255
GO:0006693prostaglandin metabolic process0.0356839973157255
GO:0022405hair cycle process0.0364856949867669
GO:0032609interferon-gamma production0.0364856949867669
GO:0042633hair cycle0.0364856949867669
GO:0022404molting cycle process0.0364856949867669
GO:0001942hair follicle development0.0364856949867669
GO:0042303molting cycle0.0364856949867669
GO:0045638negative regulation of myeloid cell differentiation0.0364856949867669
GO:0008285negative regulation of cell proliferation0.0364856949867669
GO:0045786negative regulation of progression through cell cycle0.0364856949867669
GO:0016043cellular component organization and biogenesis0.0366472503545525
GO:0046631alpha-beta T cell activation0.0377687402963367
GO:0030278regulation of ossification0.0377687402963367
GO:0008630DNA damage response, signal transduction resulting in induction of apoptosis0.0377687402963367
GO:0008637apoptotic mitochondrial changes0.0377687402963367
GO:0005773vacuole0.038105137103877
GO:0045859regulation of protein kinase activity0.0390129481834106
GO:0042542response to hydrogen peroxide0.0390129481834106
GO:0030282bone mineralization0.0390129481834106
GO:0005626insoluble fraction0.0390129481834106
GO:0006412translation0.0390929441439382
GO:0043549regulation of kinase activity0.0400328905409625
GO:0006801superoxide metabolic process0.0402108885406451
GO:0042990regulation of transcription factor import into nucleus0.0402108885406451
GO:0042991transcription factor import into nucleus0.0402108885406451
GO:0065009regulation of a molecular function0.0406298812614006
GO:0051338regulation of transferase activity0.0408596433951566
GO:0033157regulation of intracellular protein transport0.041219363387219
GO:0042306regulation of protein import into nucleus0.041219363387219
GO:0030139endocytic vesicle0.041219363387219
GO:0000060protein import into nucleus, translocation0.041219363387219
GO:0001819positive regulation of cytokine production0.0426329487877967
GO:0030595leukocyte chemotaxis0.0426329487877967
GO:0043065positive regulation of apoptosis0.0426329487877967
GO:0043068positive regulation of programmed cell death0.0431091079967831
GO:0046850regulation of bone remodeling0.0439882509742389
GO:0032507maintenance of cellular protein localization0.0439882509742389
GO:0044249cellular biosynthetic process0.0439882509742389
GO:0006139nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0439882509742389
GO:0031347regulation of defense response0.0447366974570079
GO:0050727regulation of inflammatory response0.0447366974570079
GO:0032386regulation of intracellular transport0.0447366974570079
GO:0051241negative regulation of multicellular organismal process0.0447366974570079
GO:0051651maintenance of cellular localization0.0447366974570079
GO:0050708regulation of protein secretion0.0461966376457733
GO:0016599caveolar membrane0.0461966376457733
GO:0051239regulation of multicellular organismal process0.0472621212070386
GO:0000302response to reactive oxygen species0.0474780523200585
GO:0050851antigen receptor-mediated signaling pathway0.0474780523200585
GO:0005887integral to plasma membrane0.0485736303885399
GO:0016044membrane organization and biogenesis0.0485736303885399
GO:0051223regulation of protein transport0.0485736303885399
GO:0051098regulation of binding0.0485736303885399
GO:0031226intrinsic to plasma membrane0.0494799751479102
GO:0046822regulation of nucleocytoplasmic transport0.0494799751479102
GO:0019079viral genome replication0.0494799751479102
GO:0005901caveola0.0494799751479102
GO:0030183B cell differentiation0.0494799751479102



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
classical monocyte4.05e-9342
CD14-positive, CD16-negative classical monocyte4.05e-9342
defensive cell1.34e-9248
phagocyte1.34e-9248
myeloid leukocyte3.56e-8872
macrophage dendritic cell progenitor1.18e-7861
monopoietic cell3.87e-7859
monocyte3.87e-7859
monoblast3.87e-7859
promonocyte3.87e-7859
granulocyte monocyte progenitor cell9.75e-7767
myeloid lineage restricted progenitor cell9.43e-7566
leukocyte1.49e-67136
nongranular leukocyte1.80e-59115
myeloid cell2.99e-56108
common myeloid progenitor2.99e-56108
hematopoietic lineage restricted progenitor cell4.53e-56120
hematopoietic stem cell1.88e-51168
angioblastic mesenchymal cell1.88e-51168
hematopoietic oligopotent progenitor cell9.75e-49161
hematopoietic multipotent progenitor cell9.75e-49161
hematopoietic cell5.75e-48177
stuff accumulating cell3.71e-4587
intermediate monocyte1.38e-159
CD14-positive, CD16-positive monocyte1.38e-159
mesenchymal cell1.81e-15354
connective tissue cell7.61e-15361
motile cell1.18e-12386
granulocyte3.83e-118
multi fate stem cell5.25e-10427
somatic stem cell1.21e-09433
stem cell3.54e-09441
neutrophil7.78e-093
blood cell7.21e-0811
single nucleate cell1.02e-073
mononuclear cell1.02e-073
natural killer cell2.50e-073
pro-NK cell2.50e-073
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.37e-7898
blood island1.37e-7898
hemolymphoid system7.29e-70108
bone marrow4.31e-6676
bone element2.79e-6082
immune system2.16e-5893
skeletal element9.94e-5490
skeletal system5.26e-47100
lateral plate mesoderm6.08e-31203
musculoskeletal system9.54e-23167
mesoderm4.69e-15315
mesoderm-derived structure4.69e-15315
presumptive mesoderm4.69e-15315
connective tissue5.38e-14371
blood3.21e-1115
haemolymphatic fluid3.21e-1115
organism substance3.21e-1115


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.81584e-14
MA0004.10.00608749
MA0006.10.113957
MA0007.10.0281868
MA0009.10.264004
MA0014.18.19678e-15
MA0017.10.147413
MA0019.10.505921
MA0024.10.0531496
MA0025.10.810886
MA0027.11.19827
MA0028.10.000465746
MA0029.10.061567
MA0030.10.15241
MA0031.10.207764
MA0038.10.0726003
MA0040.12.01726
MA0041.10.880288
MA0042.11.85959
MA0043.10.26442
MA0046.10.0236623
MA0048.10.00356235
MA0050.10.180328
MA0051.10.350482
MA0052.10.0661032
MA0055.10.000400034
MA0056.10
MA0057.10.000181905
MA0058.10.00580739
MA0059.10.295979
MA0060.15.96131e-07
MA0061.10.190684
MA0063.10
MA0066.10.139439
MA0067.10.133805
MA0068.10.371628
MA0069.10.244931
MA0070.10.0926055
MA0071.10.0910146
MA0072.10.225438
MA0073.10.107122
MA0074.10.0299644
MA0076.10.0194468
MA0077.10.415001
MA0078.10.181204
MA0081.10.052354
MA0083.10.0270626
MA0084.11.2573
MA0087.11.02465
MA0088.10.0151452
MA0089.10
MA0090.10.310707
MA0091.10.00640894
MA0092.10.924791
MA0093.10.000973146
MA0095.10
MA0098.10
MA0100.10.0847493
MA0101.10.0832564
MA0103.10.369407
MA0105.10.0659236
MA0106.10.112385
MA0107.10.136111
MA0108.20.363761
MA0109.10
MA0111.10.637802
MA0113.10.549833
MA0114.10.083889
MA0115.10.325356
MA0116.10.0147633
MA0117.10.0332939
MA0119.10.0383641
MA0122.10.354237
MA0124.10.990124
MA0125.10.197644
MA0130.10
MA0131.10.0449409
MA0132.10
MA0133.10
MA0135.10.305544
MA0136.10.0786254
MA0139.10.000507373
MA0140.10.0433463
MA0141.10.394054
MA0142.10.492028
MA0143.10.373639
MA0144.10.173234
MA0145.10.000349724
MA0146.10.00145119
MA0147.10.0289542
MA0148.10.392786
MA0149.10.492889
MA0062.24.61243e-06
MA0035.20.251265
MA0039.24.65495e-09
MA0138.20.183007
MA0002.20.868621
MA0137.20.430129
MA0104.20.000801925
MA0047.20.859789
MA0112.20.0706781
MA0065.20.0888801
MA0150.11.04727
MA0151.10
MA0152.10.74957
MA0153.10.0486099
MA0154.10.00378425
MA0155.10.00953078
MA0156.10.00515154
MA0157.10.418652
MA0158.10
MA0159.10.0755506
MA0160.10.612112
MA0161.10
MA0162.11.15719e-15
MA0163.14.14228e-05
MA0164.10.407414
MA0080.20.120586
MA0018.20.206319
MA0099.20.168756
MA0079.20
MA0102.20.265831
MA0258.10.50732
MA0259.10.00102101
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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