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Coexpression cluster:C4267

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Full id: C4267_splenic_plasma_Burkitt_diffuse_xeroderma_b_migratory



Phase1 CAGE Peaks

  Short description
Hg19::chr3:111852046..111852053,- p4@GCET2
Hg19::chr3:111852061..111852127,- p1@GCET2
Hg19::chr3:111852128..111852139,- p2@GCET2


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Cell Type
Ontology termp-valuen
lymphocyte2.25e-5153
common lymphoid progenitor2.25e-5153
lymphoid lineage restricted progenitor cell4.58e-5052
nucleate cell7.33e-4955
lymphocyte of B lineage1.35e-3224
pro-B cell1.35e-3224
leukocyte3.71e-32136
hematopoietic cell1.65e-29177
hematopoietic stem cell3.22e-29168
angioblastic mesenchymal cell3.22e-29168
nongranular leukocyte7.62e-27115
hematopoietic lineage restricted progenitor cell1.01e-25120
hematopoietic oligopotent progenitor cell5.11e-24161
hematopoietic multipotent progenitor cell5.11e-24161
B cell2.63e-1914
mature alpha-beta T cell8.92e-1818
alpha-beta T cell8.92e-1818
immature T cell8.92e-1818
mature T cell8.92e-1818
immature alpha-beta T cell8.92e-1818
T cell8.99e-1725
pro-T cell8.99e-1725
CD8-positive, alpha-beta T cell6.55e-1511
circulating cell1.86e-076
dendritic cell3.15e-0710
Uber Anatomy
Ontology termp-valuen
blood2.13e-0715
haemolymphatic fluid2.13e-0715
organism substance2.13e-0715
hemopoietic organ2.20e-077
immune organ2.20e-077
Disease
Ontology termp-valuen
lymphoma1.90e-0910


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.10.826076
MA0006.11.5435
MA0007.10.804807
MA0009.11.3275
MA0014.10.377374
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.886807
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.12.99448
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.13.21605
MA0106.10.986396
MA0107.13.44314
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.11.66081
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.21.20011
MA0137.21.60005
MA0104.20.491226
MA0047.20.973066
MA0112.20.731309
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.12.08673
MA0153.11.43021
MA0154.10.838867
MA0155.10.711948
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.09178
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#53335328.36945510360714.37778126761649e-050.000778894544818736
BCL3#602334.54710280373832.42397750207122e-050.000527631901498158
BCLAF1#9774321.65264761012189.8473954032885e-050.00139413329066565
CHD2#1106310.34402283411690.0009033701102746880.00661852479459686
EBF1#187938.9064668465690.00141523283560980.00917419788456659
ELF1#199734.258097958807540.01295179875054610.0463688780237311
EP300#203336.77394172622320.003216880500103790.0167891550922163
IRF4#3662321.91451268674419.49854535978121e-050.00137057001772615
MEF2A#4205318.74323090964410.0001518243905622470.00195227622826034
NFKB1#479035.488063424193840.006049381815655430.0270250400994627
NRF1#4899312.21027944771090.0005492172401020010.00472329540011635
PAX5#507936.669565531177830.003370290999677260.0173334230420689
POU2F2#545239.106124057742520.001324165192682130.00883896769516355
RAD21#5885310.35503389545630.0009004912073565420.00666098174127841
RFX5#5993312.04791082719510.0005717246050312580.00485765912991047
SIN3A#2594235.408884726815140.006318961977991520.0277614870443991
SMC3#9126315.04493284493280.0002935825420371870.00309899606911479
SP1#666735.69838137814090.005403962701712170.0247200937586666
SPI1#668838.204323508522730.001810593189410520.0109253837594664
STAT3#6774310.51946499715420.0008589184530415310.00644105581368597
TCF12#6938310.63446490218640.0008313523990202070.00630496065654429
YY1#752834.911170749853860.008441455341808260.0330292654894018
ZEB1#6935316.88843201754390.0002075486917327580.00243279212299411



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.