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MCL coexpression mm9:403

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Phase1 CAGE Peaks

 Short description
Mm9::chr12:45540065..45540076,+p9@Nrcam
Mm9::chr13:54431398..54431402,+p@chr13:54431398..54431402
+
Mm9::chr13:54467800..54467801,+p@chr13:54467800..54467801
+
Mm9::chr14:122874424..122874441,-p1@2610035F20Rik
Mm9::chr14:65208698..65208735,+p3@ENSMUST00000164162
Mm9::chr16:16560211..16560238,-p6@Fgd4
Mm9::chr16:16560239..16560290,-p3@Fgd4
Mm9::chr16:16560294..16560316,-p4@Fgd4
Mm9::chr17:26088998..26089027,-p1@ENSMUST00000162431
p1@uc008bcv.1
Mm9::chr2:105514700..105514715,+p13@Pax6
Mm9::chr2:79231715..79231718,-p6@Cerkl
Mm9::chr2:79292080..79292119,-p@chr2:79292080..79292119
-
Mm9::chr2:79294073..79294117,-p@chr2:79294073..79294117
-
Mm9::chr2:79294856..79294867,-p@chr2:79294856..79294867
-
Mm9::chr2:79295107..79295119,-p@chr2:79295107..79295119
-
Mm9::chr2:79296458..79296461,-p@chr2:79296458..79296461
-
Mm9::chr2:79296783..79296801,-p1@Neurod1
Mm9::chr2:79296907..79296918,-p2@Neurod1
Mm9::chr6:104443214..104443224,+p10@Cntn6


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0007417central nervous system development0.00179441931292426
GO:0032990cell part morphogenesis0.00179441931292426
GO:0048858cell projection morphogenesis0.00179441931292426
GO:0030030cell projection organization and biogenesis0.00179441931292426
GO:0000902cell morphogenesis0.00543333884663067
GO:0032989cellular structure morphogenesis0.00543333884663067
GO:0043010camera-type eye development0.00543333884663067
GO:0007411axon guidance0.00543333884663067
GO:0009952anterior/posterior pattern formation0.00579654942489049
GO:0021902commitment of a neuronal cell to a specific type of neuron in the forebrain0.00579654942489049
GO:0021877forebrain neuron fate commitment0.00579654942489049
GO:0045165cell fate commitment0.00579654942489049
GO:0001654eye development0.00579654942489049
GO:0007399nervous system development0.00621337240759742
GO:0048856anatomical structure development0.00854992126284358
GO:0003002regionalization0.00939158937203724
GO:0007409axonogenesis0.00969655818258358
GO:0048667neuron morphogenesis during differentiation0.00971344345791167
GO:0048812neurite morphogenesis0.00971344345791167
GO:0019227action potential propagation0.00973599120688521
GO:0007420brain development0.00995764535848094
GO:0000904cellular morphogenesis during differentiation0.00995764535848094
GO:0007423sensory organ development0.00995764535848094
GO:0009950dorsal/ventral axis specification0.00995764535848094
GO:0021798forebrain dorsal/ventral pattern formation0.00995764535848094
GO:0031175neurite development0.00995764535848094
GO:0045944positive regulation of transcription from RNA polymerase II promoter0.00995764535848094
GO:0005515protein binding0.0100964278780441
GO:0048666neuron development0.0113321223092617
GO:0007389pattern specification process0.0114503423936315
GO:0045893positive regulation of transcription, DNA-dependent0.0114503423936315
GO:0022612gland morphogenesis0.0114503423936315
GO:0021871forebrain regionalization0.0114503423936315
GO:0007435salivary gland morphogenesis0.0114503423936315
GO:0021879forebrain neuron differentiation0.0129756327257196
GO:0009653anatomical structure morphogenesis0.0134212707117066
GO:0016477cell migration0.0135297673807931
GO:0021872generation of neurons in the forebrain0.0135297673807931
GO:0030182neuron differentiation0.0135297673807931
GO:0045941positive regulation of transcription0.0135699617528827
GO:0045935positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0137588549566502
GO:0032502developmental process0.0137588549566502
GO:0030035microspike biogenesis0.0147401905676848
GO:0007257activation of JNK activity0.0147401905676848
GO:0048699generation of neurons0.0149698395928933
GO:0043507positive regulation of JNK activity0.0149698395928933
GO:0006928cell motility0.0149698395928933
GO:0051674localization of cell0.0149698395928933
GO:0007431salivary gland development0.0156176295143254
GO:0022008neurogenesis0.0156176295143254
GO:0031325positive regulation of cellular metabolic process0.0161895943822009
GO:0030175filopodium0.0161895943822009
GO:0042995cell projection0.0161895943822009
GO:0021543pallium development0.0161895943822009
GO:0035272exocrine system development0.0161895943822009
GO:0042462eye photoreceptor cell development0.0161895943822009
GO:0009893positive regulation of metabolic process0.0161895943822009
GO:0043506regulation of JNK activity0.0163791565715026
GO:0030032lamellipodium biogenesis0.0163791565715026
GO:0006357regulation of transcription from RNA polymerase II promoter0.0163791565715026
GO:0045665negative regulation of neuron differentiation0.0167262475532054
GO:0001754eye photoreceptor cell differentiation0.0167262475532054
GO:0009798axis specification0.0172143878295004
GO:0042461photoreceptor cell development0.0172143878295004
GO:0021983pituitary gland development0.0179446169784669
GO:0006366transcription from RNA polymerase II promoter0.0181984630979
GO:0021536diencephalon development0.0193390463751049
GO:0048663neuron fate commitment0.0197152584466631
GO:0046530photoreceptor cell differentiation0.0197152584466631
GO:0048731system development0.0209800527282815
GO:0021537telencephalon development0.0209800527282815
GO:0001709cell fate determination0.0215107127193711
GO:0048869cellular developmental process0.0215107127193711
GO:0030154cell differentiation0.0215107127193711
GO:0045664regulation of neuron differentiation0.0233050062515438
GO:0022610biological adhesion0.0298487604054241
GO:0007155cell adhesion0.0298487604054241
GO:0000187activation of MAPK activity0.0298487604054241
GO:0043406positive regulation of MAP kinase activity0.0334792427771437
GO:0030902hindbrain development0.0334792427771437
GO:0007254JNK cascade0.0334792427771437
GO:0009953dorsal/ventral pattern formation0.0334792427771437
GO:0048592eye morphogenesis0.0334792427771437
GO:0050767regulation of neurogenesis0.0346117301328483
GO:0031098stress-activated protein kinase signaling pathway0.0349608027389977
GO:0030031cell projection biogenesis0.0355554181013376
GO:0035270endocrine system development0.0355554181013376
GO:0007275multicellular organismal development0.0355554181013376
GO:0030027lamellipodium0.0355554181013376
GO:0007219Notch signaling pathway0.0358739848435849
GO:0030334regulation of cell migration0.0367876692441853
GO:0048522positive regulation of cellular process0.0367876692441853
GO:0005089Rho guanyl-nucleotide exchange factor activity0.0367876692441853
GO:0001764neuron migration0.0377614798551938
GO:0035023regulation of Rho protein signal transduction0.0380391672205281
GO:0005088Ras guanyl-nucleotide exchange factor activity0.039237748839414
GO:0051270regulation of cell motility0.039237748839414
GO:0043405regulation of MAP kinase activity0.0394912962577309
GO:0016043cellular component organization and biogenesis0.0398863744207733
GO:0030424axon0.0399827555688522
GO:0040012regulation of locomotion0.0402209771220318
GO:0048518positive regulation of biological process0.0437803629891882
GO:0048732gland development0.0462705259130253
GO:0031252leading edge0.0470538335527206
GO:0007266Rho protein signal transduction0.0490371344115926



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
CNS neuron (sensu Vertebrata)1.38e-1023
neuroblast (sensu Vertebrata)1.38e-1023

Uber Anatomy
Ontology termp-valuen
neurectoderm3.57e-3164
neural plate3.57e-3164
presumptive neural plate3.57e-3164
pre-chordal neural plate2.26e-2849
ecto-epithelium6.95e-2673
ectoderm-derived structure1.56e-2595
ectoderm1.56e-2595
presumptive ectoderm1.56e-2595
regional part of nervous system1.75e-2154
neural tube5.99e-2152
neural rod5.99e-2152
future spinal cord5.99e-2152
neural keel5.99e-2152
brain8.46e-2147
future brain8.46e-2147
central nervous system3.07e-2073
regional part of brain1.12e-1946
nervous system2.04e-1975
structure with developmental contribution from neural crest3.75e-1892
anterior neural tube2.41e-1640
eye2.17e-159
camera-type eye2.17e-159
simple eye2.17e-159
immature eye2.17e-159
ocular region2.17e-159
visual system2.17e-159
face2.17e-159
optic cup2.17e-159
optic vesicle2.17e-159
eye primordium2.17e-159
regional part of forebrain2.60e-1539
forebrain2.60e-1539
future forebrain2.60e-1539
subdivision of head3.83e-1211
sense organ6.26e-1112
sensory system6.26e-1112
entire sense organ system6.26e-1112
head6.63e-1013
ectodermal placode6.63e-1013
gray matter3.83e-0934
brain grey matter7.23e-0929
regional part of telencephalon7.23e-0929
telencephalon7.23e-0929
diencephalon2.74e-0810
future diencephalon2.74e-0810


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.0710448
MA0004.10.527785
MA0006.10.561862
MA0007.10.168178
MA0009.10.535932
MA0014.10.219316
MA0017.10.0906268
MA0019.10.982191
MA0024.10.496718
MA0025.10.751694
MA0027.12.14278
MA0028.10.280241
MA0029.10.477444
MA0030.10.483253
MA0031.10.451927
MA0038.10.779388
MA0040.10.547233
MA0041.10.129017
MA0042.10.384176
MA0043.10.624178
MA0046.10.568473
MA0048.10.503616
MA0050.10.205672
MA0051.10.2928
MA0052.10.554531
MA0055.10.018284
MA0056.10
MA0057.10.998407
MA0058.11.23123
MA0059.11.27869
MA0060.10.161631
MA0061.10.0537092
MA0063.10
MA0066.10.759694
MA0067.10.857286
MA0068.10.723922
MA0069.10.554839
MA0070.10.54606
MA0071.10.20507
MA0072.10.538403
MA0073.12.22021
MA0074.10.695974
MA0076.10.101055
MA0077.10.518913
MA0078.10.319336
MA0081.10.429201
MA0083.10.623446
MA0084.11.1752
MA0087.11.42725
MA0088.10.294412
MA0089.10
MA0090.10.15538
MA0091.14.84435
MA0092.10.155586
MA0093.10.609251
MA0095.10
MA0098.10
MA0100.10.2406
MA0101.10.12981
MA0103.10.319254
MA0105.10.410191
MA0106.10.325663
MA0107.10.310214
MA0108.21.81046
MA0109.10
MA0111.10.164756
MA0113.10.302851
MA0114.10.195359
MA0115.10.626759
MA0116.10.076822
MA0117.10.597086
MA0119.10.407675
MA0122.10.615314
MA0124.10.80652
MA0125.10.736412
MA0130.10
MA0131.10.372683
MA0132.10
MA0133.10
MA0135.11.58233
MA0136.10.264624
MA0139.10.299978
MA0140.10.240513
MA0141.10.10748
MA0142.10.439269
MA0143.10.31603
MA0144.10.19926
MA0145.10.0269479
MA0146.10.0222468
MA0147.10.469804
MA0148.10.189643
MA0149.10.133214
MA0062.20.0890335
MA0035.20.68369
MA0039.20.0241624
MA0138.20.366012
MA0002.20.129512
MA0137.20.3443
MA0104.20.609994
MA0047.20.778011
MA0112.20.326529
MA0065.20.027137
MA0150.10.168102
MA0151.10
MA0152.10.285194
MA0153.10.67335
MA0154.10.0518625
MA0155.10.215697
MA0156.10.100572
MA0157.10.411541
MA0158.10
MA0159.10.0638985
MA0160.10.191754
MA0161.10
MA0162.10.359472
MA0163.10.0605054
MA0164.10.73183
MA0080.20.0935932
MA0018.20.272436
MA0099.20.947425
MA0079.20.375401
MA0102.21.22663
MA0258.10.709555
MA0259.10.444163
MA0442.10
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