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Coexpression cluster:C3645

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Full id: C3645_ductus_seminal_alveolar_endometrial_Smooth_small_nonsmall



Phase1 CAGE Peaks

Hg19::chr17:46675539..46675551,-p7@HOXB6
Hg19::chr17:46675558..46675577,-p2@HOXB6
Hg19::chr17:46675586..46675600,-p6@HOXB6


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
cavitated compound organ1.89e-1831
trunk3.85e-18199
mesenchyme4.74e-18160
entire embryonic mesenchyme4.74e-18160
kidney1.01e-1526
kidney mesenchyme1.01e-1526
upper urinary tract1.01e-1526
kidney rudiment1.01e-1526
kidney field1.01e-1526
excretory tube1.32e-1416
kidney epithelium1.32e-1416
nephron epithelium1.13e-1315
renal tubule1.13e-1315
nephron tubule1.13e-1315
nephron1.13e-1315
uriniferous tubule1.13e-1315
nephrogenic mesenchyme1.13e-1315
parenchyma2.15e-1215
cortex of kidney6.34e-1212
renal parenchyma6.34e-1212
renal system7.07e-1248
subdivision of trunk1.45e-11112
abdominal segment of trunk1.65e-1160
abdomen1.65e-1160
trunk mesenchyme1.87e-11122
urinary system structure2.02e-1147
epithelial vesicle1.71e-1078
abdomen element2.61e-1054
abdominal segment element2.61e-1054
duct2.76e-1019
cortex9.34e-1015
mesonephros1.39e-099
pronephros1.39e-099
nephrogenic cord1.39e-099
pronephric mesoderm1.39e-099
rostral part of nephrogenic cord1.39e-099
presumptive pronephric mesoderm1.39e-099
organism subdivision1.46e-09264
nephron tubule epithelium3.10e-0910
trunk region element5.57e-09101
intraembryonic coelom6.39e-0912
epithelial tube7.78e-09117
mesonephric epithelium1.45e-088
mesonephric tubule1.45e-088
nephric duct1.45e-088
renal duct1.45e-088
mesonephric duct1.45e-088
pronephric duct1.45e-088
vessel4.61e-0868
unilaminar epithelium8.25e-08148
primitive nephron1.24e-077
renal glomerulus1.24e-077
renal corpuscle1.24e-077
glomerular capsule1.24e-077
metanephric mesenchyme1.24e-077
glomerular tuft1.24e-077
S-shaped body1.24e-077
renal vesicle1.24e-077
comma-shaped body1.24e-077
urogenital ridge2.98e-0711
somite5.59e-0771
presomitic mesoderm5.59e-0771
presumptive segmental plate5.59e-0771
dermomyotome5.59e-0771
trunk paraxial mesoderm5.59e-0771
paraxial mesoderm9.69e-0772
presumptive paraxial mesoderm9.69e-0772


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.178364
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.11.62115
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.12.37507
MA0056.10
MA0057.11.59304
MA0058.10.716037
MA0059.10.714521
MA0060.12.13518
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.668628
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.15.3985
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.12.18164
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.11.37817
MA0146.10.107247
MA0147.12.37462
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.22.13189
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.711948
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.0373086
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F1#186934.907389214879320.008460985347239390.0324909677052739
SUZ12#23512350.11578091106297.93834897779404e-060.000222033537464336
TRIM28#10155318.59052504526250.0001555969297255280.00196950524101374



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.