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Coexpression cluster:C3967: Difference between revisions

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|ontology_enrichment_disease=DOID:2531!4.01e-14!51;DOID:0060083!4.01e-14!51;DOID:1240!1.06e-11!39;DOID:8692!9.02e-11!31
|ontology_enrichment_disease=DOID:2531!4.01e-14!51;DOID:0060083!4.01e-14!51;DOID:1240!1.06e-11!39;DOID:8692!9.02e-11!31
|ontology_enrichment_uberon=UBERON:0002390!8.55e-36!102;UBERON:0003061!8.55e-36!102;UBERON:0002193!9.69e-36!112;UBERON:0002371!2.95e-26!80;UBERON:0002405!3.76e-23!115;UBERON:0001474!1.26e-22!86;UBERON:0004765!4.93e-18!101;UBERON:0001434!4.93e-18!101;UBERON:0007023!5.98e-14!115;UBERON:0002384!7.09e-14!375;UBERON:0003081!1.43e-11!216;UBERON:0000178!8.07e-08!15;UBERON:0000179!8.07e-08!15;UBERON:0000463!8.07e-08!15
|ontology_enrichment_uberon=UBERON:0002390!8.55e-36!102;UBERON:0003061!8.55e-36!102;UBERON:0002193!9.69e-36!112;UBERON:0002371!2.95e-26!80;UBERON:0002405!3.76e-23!115;UBERON:0001474!1.26e-22!86;UBERON:0004765!4.93e-18!101;UBERON:0001434!4.93e-18!101;UBERON:0007023!5.98e-14!115;UBERON:0002384!7.09e-14!375;UBERON:0003081!1.43e-11!216;UBERON:0000178!8.07e-08!15;UBERON:0000179!8.07e-08!15;UBERON:0000463!8.07e-08!15
|tf_chipseq_enrich=ELF1#1997;3:4.25809795880754:0.0129517987505461:0.0462752868430188!SPI1#6688;3:8.20432350852273:0.00181059318941052:0.0109134034806282
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}}
}}

Revision as of 14:23, 5 September 2012


Full id: C3967_Neutrophils_CD19_Eosinophils_Macrophage_CD14_Monocytederived_Basophils



Phase1 CAGE Peaks

Hg19::chr1:31230650..31230683,-p2@LAPTM5
Hg19::chr1:31230687..31230701,-p3@LAPTM5
Hg19::chr4:80994619..80994633,-p6@ANTXR2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0031090organelle membrane0.0376431503972593
GO:0005765lysosomal membrane0.0376431503972593
GO:0005774vacuolar membrane0.0376431503972593
GO:0044437vacuolar part0.0376431503972593



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell2.16e-75172
angioblastic mesenchymal cell2.16e-75172
hematopoietic oligopotent progenitor cell1.74e-71165
hematopoietic multipotent progenitor cell1.74e-71165
hematopoietic cell1.55e-70182
leukocyte4.39e-63140
hematopoietic lineage restricted progenitor cell9.42e-53124
nongranular leukocyte2.86e-50119
myeloid cell3.81e-47112
common myeloid progenitor3.81e-47112
myeloid leukocyte1.13e-3576
granulocyte monocyte progenitor cell4.01e-3171
myeloid lineage restricted progenitor cell1.36e-3070
macrophage dendritic cell progenitor1.16e-2765
monopoietic cell4.51e-2763
monocyte4.51e-2763
monoblast4.51e-2763
promonocyte4.51e-2763
CD14-positive, CD16-negative classical monocyte3.59e-2442
classical monocyte1.84e-2045
lymphocyte3.11e-2053
common lymphoid progenitor3.11e-2053
lymphoid lineage restricted progenitor cell6.77e-2052
mesenchymal cell1.40e-16358
connective tissue cell6.62e-15365
lymphocyte of B lineage6.43e-1224
pro-B cell6.43e-1224
motile cell2.04e-10390
T cell2.49e-0825
pro-T cell2.49e-0825
B cell2.95e-0814
mature alpha-beta T cell8.87e-0818
alpha-beta T cell8.87e-0818
immature T cell8.87e-0818
mature T cell8.87e-0818
immature alpha-beta T cell8.87e-0818
multi fate stem cell2.45e-07430
Uber Anatomy
Ontology termp-valuen
hematopoietic system8.55e-36102
blood island8.55e-36102
hemolymphoid system9.69e-36112
bone marrow2.95e-2680
immune system3.76e-23115
bone element1.26e-2286
skeletal element4.93e-18101
skeletal system4.93e-18101
adult organism5.98e-14115
connective tissue7.09e-14375
lateral plate mesoderm1.43e-11216
blood8.07e-0815
haemolymphatic fluid8.07e-0815
organism substance8.07e-0815
Disease
Ontology termp-valuen
hematologic cancer4.01e-1451
immune system cancer4.01e-1451
leukemia1.06e-1139
myeloid leukemia9.02e-1131


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ELF1#199734.258097958807540.01295179875054610.0462752868430188
SPI1#668838.204323508522730.001810593189410520.0109134034806282



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.