Coexpression cluster:C2241

Full id: C2241_cerebellum_spinal_thalamus_medulla_substantia_occipital_hippocampus

Phase1 CAGE Peaks

Hg19::chr12:75784669..75784698,-	p1@CAPS2
Hg19::chr19:44455368..44455396,+	p1@ZNF221
Hg19::chr1:144932014..144932132,-	p3@PDE4DIP
Hg19::chr9:95640300..95640345,-	p1@ZNF484

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
adult organism	6.32e-38	115
central nervous system	3.48e-33	82
regional part of nervous system	1.24e-32	94
nervous system	1.24e-32	94
neural tube	1.53e-30	57
neural rod	1.53e-30	57
future spinal cord	1.53e-30	57
neural keel	1.53e-30	57
brain	6.37e-28	69
future brain	6.37e-28	69
regional part of brain	8.03e-28	59
anterior neural tube	4.83e-26	42
regional part of forebrain	1.21e-25	41
forebrain	1.21e-25	41
future forebrain	1.21e-25	41
ectoderm-derived structure	1.50e-24	169
ectoderm	3.14e-24	173
presumptive ectoderm	3.14e-24	173
neural plate	2.43e-23	86
presumptive neural plate	2.43e-23	86
anterior region of body	2.71e-23	129
craniocervical region	2.71e-23	129
head	1.24e-22	123
neurectoderm	1.37e-22	90
gray matter	3.16e-21	34
brain grey matter	3.16e-21	34
telencephalon	3.59e-21	34
regional part of telencephalon	1.43e-20	33
cerebral hemisphere	7.09e-20	32
pre-chordal neural plate	1.61e-17	61
cerebral cortex	1.08e-15	25
pallium	1.08e-15	25
regional part of cerebral cortex	1.13e-14	22
neocortex	2.01e-13	20
organism subdivision	7.59e-10	365
basal ganglion	5.19e-07	9
nuclear complex of neuraxis	5.19e-07	9
aggregate regional part of brain	5.19e-07	9
collection of basal ganglia	5.19e-07	9
cerebral subcortex	5.19e-07	9
nucleus of brain	5.29e-07	9
neural nucleus	5.29e-07	9

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
ELF1#1997	4	4.25809795880754	0.00304152556578124	0.0160666576584202
ETS1#2113	3	7.29657069165175	0.0040085737751139	0.0192006712758724
GABPB1#2553	3	5.30076287713663	0.0101267882423427	0.0378455463122462
MAFF#23764	2	28.1576782449726	0.00184687618036715	0.0109234285537074
MAFK#7975	2	13.550366568915	0.0077720281209805	0.0319505154468444
MAX#4149	3	4.83941663175534	0.0131573713783684	0.0466032255777458
NANOG#79923	2	14.6223892405063	0.00669875771536376	0.0284823334704586
NFKB1#4790	4	5.48806342419384	0.00110219956630198	0.00767059508929248
NRF1#4899	3	9.15770958578318	0.00206195379173342	0.0119598129542845
PBX3#5090	2	10.9572563433721	0.0117453018068803	0.0428260857943922
RAD21#5885	3	7.76627542159225	0.003341119385872	0.0172633041874579
SETDB1#9869	2	20.1600130890052	0.0035690868540764	0.0180824615287128
SIX5#147912	3	12.8150365165942	0.000766447113693038	0.00601404734087057
SMC3#9126	3	11.2836996336996	0.00111580236686805	0.00765558293215956
STAT1#6772	3	15.5299406228994	0.00043408865517555	0.00404964582919868
STAT3#6774	4	10.5194649971542	8.16377768286615e-05	0.00122961750421237
TAF1#6872	4	3.34304628574529	0.00800566489870165	0.032150412841479
TBP#6908	4	3.70677068709639	0.00529637781478435	0.0243699181689251
TRIM28#10155	4	18.5905250452625	8.36730015875654e-06	0.000229785027946457
YY1#7528	4	4.91117074985386	0.0017187183805544	0.0106674528404779
ZNF143#7702	4	13.5008765522279	3.00867915035614e-05	0.000620137047136461
ZNF263#10127	4	8.22184163701068	0.000218787118095832	0.00248179730930929

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.