Coexpression cluster:C4265

Full id: C4265_heart_Fibroblast_Endothelial_smooth_mesodermal_Ciliary_mature

Phase1 CAGE Peaks

Hg19::chr3:111578558..111578576,+	p6@PHLDB2
Hg19::chr3:111578583..111578620,+	p4@PHLDB2
Hg19::chr3:111578650..111578707,+	p2@PHLDB2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	3.97e-18	180
mesodermal cell	2.48e-17	119
muscle precursor cell	1.26e-13	57
myoblast	1.26e-13	57
multi-potent skeletal muscle stem cell	1.26e-13	57
muscle cell	2.69e-13	54
contractile cell	3.66e-12	59
electrically responsive cell	1.74e-11	60
electrically active cell	1.74e-11	60
embryonic cell	4.88e-10	248
smooth muscle cell	2.90e-09	42
smooth muscle myoblast	2.90e-09	42
vascular associated smooth muscle cell	9.48e-09	32
fibroblast	2.50e-08	75
endothelial cell of vascular tree	9.43e-07	24

Uber Anatomy

Ontology term	p-value	n
splanchnic layer of lateral plate mesoderm	3.37e-21	84
circulatory system	1.04e-19	113
vasculature	3.57e-19	79
vascular system	3.57e-19	79
cardiovascular system	1.89e-18	110
epithelial tube	7.19e-17	118
unilaminar epithelium	1.03e-16	138
blood vessel	2.29e-15	60
epithelial tube open at both ends	2.29e-15	60
blood vasculature	2.29e-15	60
vascular cord	2.29e-15	60
vessel	3.81e-15	69
muscle tissue	2.43e-14	63
musculature	2.43e-14	63
musculature of body	2.43e-14	63
skeletal muscle tissue	7.27e-14	61
striated muscle tissue	7.27e-14	61
myotome	7.27e-14	61
dermomyotome	4.05e-13	70
somite	4.15e-13	83
paraxial mesoderm	4.15e-13	83
presomitic mesoderm	4.15e-13	83
presumptive segmental plate	4.15e-13	83
trunk paraxial mesoderm	4.15e-13	83
presumptive paraxial mesoderm	4.15e-13	83
trunk mesenchyme	2.75e-12	143
cell layer	5.02e-12	312
epithelium	1.03e-11	309
multi-tissue structure	6.96e-11	347
artery	1.34e-10	42
arterial blood vessel	1.34e-10	42
arterial system	1.34e-10	42
trunk	1.66e-10	216
multilaminar epithelium	2.19e-10	82
primary circulatory organ	3.36e-10	27
mesenchyme	4.09e-10	238
entire embryonic mesenchyme	4.09e-10	238
anatomical cluster	4.79e-10	286
organism subdivision	5.86e-10	365
multi-cellular organism	1.40e-09	659
heart	7.26e-09	24
primitive heart tube	7.26e-09	24
primary heart field	7.26e-09	24
anterior lateral plate mesoderm	7.26e-09	24
heart tube	7.26e-09	24
heart primordium	7.26e-09	24
cardiac mesoderm	7.26e-09	24
cardiogenic plate	7.26e-09	24
heart rudiment	7.26e-09	24
systemic artery	9.92e-09	33
systemic arterial system	9.92e-09	33
anatomical conduit	1.09e-07	241
anatomical system	3.07e-07	625
aorta	3.50e-07	21
aortic system	3.50e-07	21
anatomical group	4.81e-07	626

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CTCF#10664	3	5.36025637307503	0.006492509252767	0.0280345298652058
E2F1#1869	3	4.90738921487932	0.00846098534723939	0.0326482246612109
EP300#2033	3	6.7739417262232	0.00321688050010379	0.0167883161378343
JUND#3727	3	6.99466394187103	0.00292184504273499	0.015715845620755
SMARCC2#6601	3	94.1553744268976	1.19621075407887e-06	4.86113054261646e-05
TCF7L2#6934	3	10.7701765631373	0.000800318129839838	0.00615723205615785

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.