MCL coexpression mm9:2770

Phase1 CAGE Peaks

	Short description
Mm9::chr12:113882847..113882895,+	p4@Siva1
Mm9::chr5:24191633..24191637,+	p3@Nub1
Mm9::chr5:24191651..24191671,+	p2@Nub1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005175	CD27 receptor binding	0.00383498602969375
GO:0001618	viral receptor activity	0.00383498602969375
GO:0009303	rRNA transcription	0.0127818860110145
GO:0005164	tumor necrosis factor receptor binding	0.0275990404862792
GO:0032813	tumor necrosis factor receptor superfamily binding	0.0275990404862792

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
gray matter	2.67e-14	34
brain grey matter	7.37e-14	29
regional part of telencephalon	7.37e-14	29
telencephalon	7.37e-14	29
regional part of forebrain	8.10e-13	39
forebrain	8.10e-13	39
future forebrain	8.10e-13	39
anterior neural tube	1.72e-12	40
brain	2.06e-12	47
future brain	2.06e-12	47
regional part of nervous system	2.19e-12	54
neural tube	5.49e-12	52
neural rod	5.49e-12	52
future spinal cord	5.49e-12	52
neural keel	5.49e-12	52
regional part of brain	7.27e-12	46
cerebral cortex	1.80e-11	21
cerebral hemisphere	1.80e-11	21
pallium	1.80e-11	21
pre-chordal neural plate	9.57e-11	49
central nervous system	8.57e-10	73
neurectoderm	1.04e-09	64
neural plate	1.04e-09	64
presumptive neural plate	1.04e-09	64
nervous system	4.21e-09	75
regional part of cerebral cortex	6.11e-09	17
ecto-epithelium	1.64e-08	73
occipital lobe	1.56e-07	10
visual cortex	1.56e-07	10
neocortex	1.56e-07	10
ectoderm-derived structure	5.33e-07	95
ectoderm	5.33e-07	95
presumptive ectoderm	5.33e-07	95

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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