MCL coexpression mm9:864

Phase1 CAGE Peaks

	Short description
Mm9::chr10:4978013..4978035,+	p14@Syne1
Mm9::chr10:4978043..4978055,+	p17@Syne1
Mm9::chr10:4978078..4978090,+	p22@Syne1
Mm9::chr10:4978881..4978904,+	p16@Syne1
Mm9::chr10:5007643..5007657,+	p@chr10:5007643..5007657 +
Mm9::chr19:29038341..29038367,+	p3@Ppapdc2
Mm9::chr9:56482905..56482942,-	p2@Lingo1
Mm9::chrX:164857590..164857595,-	p@chrX:164857590..164857595 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0048715	negative regulation of oligodendrocyte differentiation	0.0158608441727178
GO:0048713	regulation of oligodendrocyte differentiation	0.0158608441727178
GO:0014014	negative regulation of gliogenesis	0.0158608441727178
GO:0045686	negative regulation of glial cell differentiation	0.0158608441727178
GO:0005154	epidermal growth factor receptor binding	0.0158608441727178
GO:0045685	regulation of glial cell differentiation	0.0158608441727178
GO:0014013	regulation of gliogenesis	0.0158608441727178
GO:0048709	oligodendrocyte differentiation	0.0158608441727178
GO:0043491	protein kinase B signaling cascade	0.0158608441727178
GO:0021954	central nervous system neuron development	0.0272368829429225
GO:0021953	central nervous system neuron differentiation	0.0282934074455258
GO:0010001	glial cell differentiation	0.040860385301581
GO:0042063	gliogenesis	0.040860385301581

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
brain	8.33e-17	47
future brain	8.33e-17	47
regional part of nervous system	4.45e-16	54
regional part of brain	5.89e-16	46
neural tube	3.58e-14	52
neural rod	3.58e-14	52
future spinal cord	3.58e-14	52
neural keel	3.58e-14	52
occipital lobe	9.36e-14	10
visual cortex	9.36e-14	10
neocortex	9.36e-14	10
anterior neural tube	1.32e-13	40
regional part of forebrain	9.94e-13	39
forebrain	9.94e-13	39
future forebrain	9.94e-13	39
central nervous system	4.77e-11	73
nervous system	1.76e-10	75
brain grey matter	5.87e-10	29
regional part of telencephalon	5.87e-10	29
telencephalon	5.87e-10	29
regional part of cerebral cortex	6.91e-10	17
neurectoderm	8.80e-10	64
neural plate	8.80e-10	64
presumptive neural plate	8.80e-10	64
pre-chordal neural plate	1.12e-09	49
cerebral cortex	7.57e-09	21
cerebral hemisphere	7.57e-09	21
pallium	7.57e-09	21
ecto-epithelium	3.94e-08	73
gray matter	1.04e-07	34
tube	1.93e-07	114
ectoderm-derived structure	9.04e-07	95
ectoderm	9.04e-07	95
presumptive ectoderm	9.04e-07	95

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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