MCL coexpression mm9:972

Phase1 CAGE Peaks

	Short description
Mm9::chr18:15561235..15561295,-	p2@Aqp4
Mm9::chr18:15562125..15562144,-	p3@Aqp4
Mm9::chr18:15562149..15562166,-	p1@Aqp4
Mm9::chr18:15562167..15562176,-	p5@Aqp4
Mm9::chr18:15562189..15562196,-	p7@Aqp4
Mm9::chr18:15562199..15562210,-	p6@Aqp4
Mm9::chr2:26185946..26185961,+	p4@Gpsm1
Mm9::chr7:107802465..107802479,-	p8@Plekhb1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030104	water homeostasis	0.0189727819534409
GO:0018987	osmoregulation	0.0189727819534409
GO:0015250	water channel activity	0.0189727819534409
GO:0005372	water transporter activity	0.0189727819534409
GO:0006833	water transport	0.0189727819534409
GO:0042044	fluid transport	0.0189727819534409
GO:0001750	photoreceptor outer segment	0.0195412882118183
GO:0005794	Golgi apparatus	0.0195412882118183
GO:0031513	nonmotile primary cilium	0.0195412882118183

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	9.57e-14	54
neural tube	1.46e-12	52
neural rod	1.46e-12	52
future spinal cord	1.46e-12	52
neural keel	1.46e-12	52
central nervous system	5.16e-11	73
nervous system	3.22e-10	75
brain	1.03e-09	47
future brain	1.03e-09	47
neurectoderm	1.07e-09	64
neural plate	1.07e-09	64
presumptive neural plate	1.07e-09	64
posterior neural tube	2.57e-09	12
chordal neural plate	2.57e-09	12
regional part of brain	3.77e-09	46
gray matter	1.10e-08	34
structure with developmental contribution from neural crest	3.30e-08	92
ecto-epithelium	5.60e-08	73
ectoderm-derived structure	5.68e-08	95
ectoderm	5.68e-08	95
presumptive ectoderm	5.68e-08	95
occipital lobe	5.60e-07	10
visual cortex	5.60e-07	10
neocortex	5.60e-07	10

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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