MCL coexpression mm9:1066

Phase1 CAGE Peaks

	Short description
Mm9::chr11:23662091..23662095,-	p@chr11:23662091..23662095 -
Mm9::chr12:60232412..60232456,+	p2@Ctage5
Mm9::chr3:106592952..106592963,-	p3@Cd53
Mm9::chr3:106592991..106593002,-	p5@Cd53
Mm9::chr3:135354349..135354371,-	p6@Nfkb1
Mm9::chr6:129182951..129182973,-	p@chr6:129182951..129182973 -
Mm9::chr7:109398216..109398228,+	p@chr7:109398216..109398228 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0045083	negative regulation of interleukin-12 biosynthetic process	0.0169287240453624
GO:0042090	interleukin-12 biosynthetic process	0.0338370468246374
GO:0045075	regulation of interleukin-12 biosynthetic process	0.0338370468246374
GO:0042036	negative regulation of cytokine biosynthetic process	0.0338370468246374
GO:0016566	specific transcriptional repressor activity	0.0338370468246374
GO:0032615	interleukin-12 production	0.0338370468246374
GO:0048535	lymph node development	0.0410765854248425
GO:0017148	negative regulation of translation	0.0488382460723203
GO:0031327	negative regulation of cellular biosynthetic process	0.0488382460723203

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
hematopoietic cell	5.08e-13	32
hematopoietic oligopotent progenitor cell	5.08e-13	32
hematopoietic stem cell	5.08e-13	32
angioblastic mesenchymal cell	5.08e-13	32
hematopoietic multipotent progenitor cell	5.08e-13	32
hematopoietic lineage restricted progenitor cell	6.12e-11	25
lymphoid lineage restricted progenitor cell	8.74e-10	12
T cell	4.31e-09	11
pro-T cell	4.31e-09	11
leukocyte	6.19e-09	17
nongranular leukocyte	6.19e-09	17
lymphocyte	3.71e-08	13
common lymphoid progenitor	3.71e-08	13
mature alpha-beta T cell	4.56e-08	9
alpha-beta T cell	4.56e-08	9
immature T cell	4.56e-08	9
mature T cell	4.56e-08	9
immature alpha-beta T cell	4.56e-08	9
CD4-positive, alpha-beta T cell	2.34e-07	8
connective tissue cell	7.00e-07	46
mesenchymal cell	7.00e-07	46

Uber Anatomy

Ontology term	p-value	n
hemolymphoid system	1.72e-18	48
immune system	1.72e-18	48
hematopoietic system	7.89e-17	45
blood island	7.89e-17	45
mixed endoderm/mesoderm-derived structure	4.04e-12	35
hemopoietic organ	2.16e-11	29
immune organ	2.16e-11	29
gland of gut	6.11e-10	24
thymus	1.41e-09	23
neck	1.41e-09	23
respiratory system epithelium	1.41e-09	23
hemolymphoid system gland	1.41e-09	23
pharyngeal epithelium	1.41e-09	23
thymic region	1.41e-09	23
pharyngeal gland	1.41e-09	23
entire pharyngeal arch endoderm	1.41e-09	23
thymus primordium	1.41e-09	23
early pharyngeal endoderm	1.41e-09	23
respiratory system	1.52e-09	42
lateral plate mesoderm	2.02e-09	87
respiratory tract	3.43e-09	41
pharynx	4.06e-09	24
upper respiratory tract	4.06e-09	24
chordate pharynx	4.06e-09	24
pharyngeal arch system	4.06e-09	24
pharyngeal region of foregut	4.06e-09	24
segment of respiratory tract	6.05e-08	27
endoderm-derived structure	1.18e-07	118
endoderm	1.18e-07	118
presumptive endoderm	1.18e-07	118
digestive system	3.35e-07	116
digestive tract	3.35e-07	116
primitive gut	3.35e-07	116
foregut	4.29e-07	80
mesoderm	6.60e-07	120
mesoderm-derived structure	6.60e-07	120
presumptive mesoderm	6.60e-07	120
connective tissue	7.00e-07	46

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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