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{{Coexpression_clusters
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|full_id=C2928_skeletal_neuroepithelioma_neuroectodermal_peripheral_tongue_throat_penis
|id=C2928
|ontology_enrichment_celltype=CL:0000066!1.73e-09!254
|ontology_enrichment_disease=DOID:0050687!2.15e-11!143;DOID:305!1.54e-10!106;DOID:14566!3.09e-10!239;DOID:162!1.76e-09!235
|ontology_enrichment_uberon=UBERON:0007023!1.53e-22!115;UBERON:0000924!3.02e-20!173;UBERON:0006601!3.02e-20!173;UBERON:0000073!1.10e-19!94;UBERON:0001016!1.10e-19!94;UBERON:0004121!1.01e-18!169;UBERON:0005743!6.81e-18!86;UBERON:0001017!1.82e-17!82;UBERON:0002346!6.34e-16!90;UBERON:0001049!9.24e-16!57;UBERON:0005068!9.24e-16!57;UBERON:0006241!9.24e-16!57;UBERON:0007135!9.24e-16!57;UBERON:0000955!7.13e-15!69;UBERON:0006238!7.13e-15!69;UBERON:0003075!2.40e-14!86;UBERON:0007284!2.40e-14!86;UBERON:0000064!7.18e-14!219;UBERON:0000922!3.71e-13!612;UBERON:0002616!3.72e-13!59;UBERON:0002780!6.60e-13!41;UBERON:0001890!6.60e-13!41;UBERON:0006240!6.60e-13!41;UBERON:0000153!1.09e-12!129;UBERON:0007811!1.09e-12!129;UBERON:0003080!3.75e-12!42;UBERON:0001893!6.54e-12!34;UBERON:0002020!8.04e-12!34;UBERON:0003528!8.04e-12!34;UBERON:0001869!1.06e-11!32;UBERON:0000033!1.11e-11!123;UBERON:0002791!1.62e-11!33;UBERON:0000481!3.31e-11!347;UBERON:0002050!3.38e-11!605;UBERON:0005423!3.38e-11!605;UBERON:0000923!6.83e-11!604;UBERON:0005291!6.83e-11!604;UBERON:0006598!6.83e-11!604;UBERON:0002532!6.83e-11!604;UBERON:0003056!9.59e-10!61;UBERON:0000468!1.34e-09!659;UBERON:0001004!3.52e-09!72;UBERON:0000062!3.81e-09!511;UBERON:0000956!6.10e-09!25;UBERON:0000203!6.10e-09!25;UBERON:0000065!1.49e-08!53;UBERON:0000483!1.80e-08!309;UBERON:0000119!4.39e-08!312;UBERON:0002619!7.52e-08!22;UBERON:0008947!2.46e-07!38;UBERON:0003258!2.46e-07!38;UBERON:0001048!2.46e-07!168;UBERON:0001950!5.12e-07!20;UBERON:0004119!5.28e-07!169;UBERON:0000925!5.28e-07!169;UBERON:0006595!5.28e-07!169
}}

Latest revision as of 12:15, 17 September 2013


Full id: C2928_skeletal_neuroepithelioma_neuroectodermal_peripheral_tongue_throat_penis



Phase1 CAGE Peaks

Hg19::chr8:75147731..75147735,-p5@JPH1
Hg19::chr8:75148890..75148893,-p@chr8:75148890..75148893
-
Hg19::chr8:75233646..75233681,-p3@JPH1
Hg19::chr8:75233767..75233785,-p1@JPH1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
nervous system4.23e-1889
adult organism1.71e-17114
ectoderm-derived structure1.78e-17171
ectoderm1.78e-17171
presumptive ectoderm1.78e-17171
organ system subdivision7.34e-17223
central nervous system1.22e-1681
regional part of nervous system4.23e-1653
regional part of brain4.23e-1653
neural tube5.01e-1656
neural rod5.01e-1656
future spinal cord5.01e-1656
neural keel5.01e-1656
brain2.31e-1568
future brain2.31e-1568
telencephalon1.84e-1434
brain grey matter2.26e-1434
gray matter2.26e-1434
regional part of forebrain2.71e-1441
forebrain2.71e-1441
anterior neural tube2.71e-1441
future forebrain2.71e-1441
cerebral hemisphere4.24e-1432
regional part of telencephalon5.92e-1432
ecto-epithelium1.53e-13104
neurectoderm5.52e-1386
cerebral cortex9.94e-1225
pallium9.94e-1225
neural plate9.96e-1282
presumptive neural plate9.96e-1282
regional part of cerebral cortex3.65e-1022
pre-chordal neural plate1.58e-0961
neocortex6.06e-0920
organ part1.64e-08218
structure with developmental contribution from neural crest1.23e-07132
embryo2.03e-07592
larynx6.48e-079
Disease
Ontology termp-valuen
cell type cancer1.90e-11143
disease of cellular proliferation5.47e-11239
cancer2.34e-10235
carcinoma1.34e-09106


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.45381
MA0004.11.69588
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.11.86845
MA0017.10.577281
MA0019.10.873355
MA0024.12.48281
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.11.28887
MA0056.10
MA0057.10.248209
MA0058.12.50688
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.0343867
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.11.62583
MA0089.10
MA0090.12.61689
MA0091.10.715356
MA0092.10.673508
MA0093.12.27878
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.12.17614
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.12.2938
MA0143.12.05538
MA0144.10.430413
MA0145.10.569905
MA0146.11.75643
MA0147.11.16748
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.257871
MA0138.22.1393
MA0002.20.379056
MA0137.20.558189
MA0104.21.79838
MA0047.20.856092
MA0112.20.551048
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.649108
MA0155.10.533581
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.12.80246
MA0163.10.539587
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.23.97967
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTBP2#1488231.35850016966410.001492676882047230.00954470586445421



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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