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{{Coexpression_clusters
{
|full_id=C4003_CD14_CD4_immature_CD8_Natural_Neutrophils_CD19

Latest revision as of 12:37, 17 September 2013


Full id: C4003_CD14_CD4_immature_CD8_Natural_Neutrophils_CD19



Phase1 CAGE Peaks

Hg19::chr1:89357240..89357257,-p1@GTF2B
Hg19::chr3:93781920..93781933,+p2@NSUN3
Hg19::chr5:42992418..42992435,+p@chr5:42992418..42992435
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
hematopoietic stem cell3.56e-58168
angioblastic mesenchymal cell3.56e-58168
leukocyte5.72e-56136
hematopoietic cell6.92e-55177
hematopoietic oligopotent progenitor cell3.23e-54161
hematopoietic multipotent progenitor cell3.23e-54161
hematopoietic lineage restricted progenitor cell2.60e-50120
nongranular leukocyte3.52e-49115
myeloid cell2.25e-29108
common myeloid progenitor2.25e-29108
myeloid leukocyte7.79e-2972
myeloid lineage restricted progenitor cell7.83e-2766
granulocyte monocyte progenitor cell5.48e-2667
monopoietic cell9.31e-2459
monocyte9.31e-2459
monoblast9.31e-2459
promonocyte9.31e-2459
nucleate cell1.04e-2355
macrophage dendritic cell progenitor1.27e-2361
classical monocyte1.49e-2342
CD14-positive, CD16-negative classical monocyte1.49e-2342
defensive cell3.25e-2348
phagocyte3.25e-2348
lymphocyte1.47e-2253
common lymphoid progenitor1.47e-2253
lymphoid lineage restricted progenitor cell3.76e-2252
mesenchymal cell3.17e-13354
connective tissue cell2.26e-12361
T cell9.88e-1225
pro-T cell9.88e-1225
mature alpha-beta T cell3.45e-1018
alpha-beta T cell3.45e-1018
immature T cell3.45e-1018
mature T cell3.45e-1018
immature alpha-beta T cell3.45e-1018
lymphocyte of B lineage5.21e-1024
pro-B cell5.21e-1024
motile cell9.57e-10386
stuff accumulating cell1.42e-0887
B cell4.20e-0814
CD8-positive, alpha-beta T cell6.41e-0711
Uber Anatomy
Ontology termp-valuen
hematopoietic system2.07e-3298
blood island2.07e-3298
hemolymphoid system3.25e-28108
bone marrow9.64e-2476
bone element6.34e-2282
immune system6.58e-2293
skeletal element3.28e-1990
skeletal system1.07e-14100
connective tissue2.05e-11371
blood1.76e-0715
haemolymphatic fluid1.76e-0715
organism substance1.76e-0715


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.11.58389
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.904546
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.557638
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.12.91768
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.21.9924
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.11.60572
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.00160703
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BRCA1#672213.45615376214920.007119807716084560.0296272849653421
E2F6#187635.017155731697390.00791769806886330.0322686517058462
EGR1#195834.988179094810140.008056488137383440.032105142116155
ELF1#199734.258097958807540.01295179875054610.0462879550254349
ELK4#2005210.8237877723120.01091284719516480.0401991693078377
GABPB1#255337.067683836182170.002832212825417420.0154284099349974
MEF2A#4205212.4954872730960.008235029478029740.0324869020040775
MYC#460935.22228187160940.007020843755740150.0294880519989442
NFKB1#479035.488063424193840.006049381815655430.0269834879749397
PAX5#507936.669565531177830.003370290999677260.0173078537500759
POU2F2#545239.106124057742520.001324165192682130.00882993797462195
SIN3A#2594235.408884726815140.006318961977991520.0277148525961472
SPI1#668838.204323508522730.001810593189410520.0109159234606503
STAT1#6772213.80439166479950.006770931708444080.0287540900540069
TRIM28#10155212.39368336350830.008368344129438470.032917083821115
ZEB1#6935316.88843201754390.0002075486917327580.00242979237931594



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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