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{{Coexpression_clusters
{
|full_id=C4731_granulocyte_acute_osteosarcoma_thymus_smallcell_hippocampus_serous

Latest revision as of 14:18, 17 September 2013


Full id: C4731_granulocyte_acute_osteosarcoma_thymus_smallcell_hippocampus_serous



Phase1 CAGE Peaks

Hg19::chr8:144450985..144451002,+p3@RHPN1
Hg19::chr8:144451007..144451031,+p2@RHPN1
Hg19::chr8:144451039..144451054,+p1@RHPN1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
epithelial cell1.26e-10253
Uber Anatomy
Ontology termp-valuen
neural tube2.64e-1956
neural rod2.64e-1956
future spinal cord2.64e-1956
neural keel2.64e-1956
regional part of nervous system8.11e-1853
regional part of brain8.11e-1853
regional part of forebrain7.40e-1741
forebrain7.40e-1741
anterior neural tube7.40e-1741
future forebrain7.40e-1741
central nervous system7.95e-1781
adult organism2.02e-16114
nervous system2.96e-1589
brain1.32e-1468
future brain1.32e-1468
telencephalon4.36e-1434
brain grey matter4.61e-1434
gray matter4.61e-1434
neurectoderm1.59e-1386
regional part of telencephalon3.33e-1332
cerebral hemisphere4.38e-1332
neural plate1.30e-1282
presumptive neural plate1.30e-1282
pre-chordal neural plate1.41e-1161
organ system subdivision3.93e-11223
cerebral cortex9.37e-1025
pallium9.37e-1025
regional part of cerebral cortex1.21e-0922
neocortex1.44e-0820
ecto-epithelium9.78e-08104
cavitated compound organ5.46e-0731
trunk region element6.27e-07101
Disease
Ontology termp-valuen
carcinoma1.26e-19106
cell type cancer7.89e-17143
cancer2.32e-12235
disease of cellular proliferation2.26e-11239
adenocarcinoma2.39e-0925


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.14.57391
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.12.45333
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.13.15662
MA0061.12.01615
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.11.84783
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.12.63873
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.13.943
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.11.12079
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.14.49708
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.432958
MA0138.21.04628
MA0002.20.476938
MA0137.22.70092
MA0104.20.491226
MA0047.20.973066
MA0112.21.34467
MA0065.20.760954
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.11.31345
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.12.05956
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.0373086
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0191234733770554
CEBPB#105137.971147625824820.001974187055288560.0115832652734428
CHD2#1106310.34402283411690.0009033701102746880.00663015256127745
E2F1#186934.907389214879320.008460985347239390.0327863182205526
E2F6#187635.017155731697390.00791769806886330.0324459102493139
EGR1#195834.988179094810140.008056488137383440.0322602394210639
ELF1#199734.258097958807540.01295179875054610.0465107763885529
ETS1#211339.728760922202340.001085840092584840.00765571143113939
FOS#235338.99795530889440.001372499272417130.0090220576228583
GABPB1#255337.067683836182170.002832212825417420.015485758613359
HMGN3#932438.178547723350590.001827766942164210.0109267402216765
IRF1#365937.63716375356390.002244692747297240.0128760073507429
IRF3#3661346.98195221148969.63568551583244e-060.000254255017581613
MXI1#460139.96157162875930.001011470541259020.00723640031912255
MYC#460935.22228187160940.007020843755740150.0296178818518296
NFKB1#479035.488063424193840.006049381815655430.0270910933255537
NFYA#4800318.42558069983050.0001598135507814160.0020027318730574
NFYB#4801316.75979325353650.0002123649923296180.00246764435179272
NRF1#4899312.21027944771090.0005492172401020010.00473655651024054
PBX3#5090321.91451268674419.49854535978121e-050.00137398695128835
SIN3A#2594235.408884726815140.006318961977991520.0278376036621865
SP1#666735.69838137814090.005403962701712170.0247950294615639
SP2#6668326.15353049384465.58768218891694e-050.000942765654488361
SREBF1#6720347.00584944048839.62099323994382e-060.000255416093794228
STAT3#6774310.51946499715420.0008589184530415310.00645821341376562
THAP1#55145331.36914460285133.23800758564397e-050.000649336164049675
USF1#739136.361499277207960.00388404057290560.0191251915791461
ZBTB7A#5134137.35190930787590.002516255860282270.0140977010778402



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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