Coexpression cluster:C1581

Full id: C1581_CD14_Basophils_Neutrophils_Eosinophils_Mast_Dendritic_Whole

Phase1 CAGE Peaks

Hg19::chr10:45914854..45914887,-	p@chr10:45914854..45914887 -
Hg19::chr10:75571566..75571584,-	p2@NDST2
Hg19::chr15:63414583..63414595,-	p@chr15:63414583..63414595 -
Hg19::chr22:37309662..37309694,+	p1@CSF2RB
Hg19::chr22:37319278..37319288,+	p@chr22:37319278..37319288 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030526	granulocyte macrophage colony-stimulating factor receptor complex	0.00250787389551549
GO:0019978	interleukin-3 binding	0.00250787389551549
GO:0004912	interleukin-3 receptor activity	0.00250787389551549
GO:0004914	interleukin-5 receptor activity	0.00250787389551549
GO:0019980	interleukin-5 binding	0.00250787389551549
GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity	0.00278648553605186
GO:0015012	heparan sulfate proteoglycan biosynthetic process	0.00537354089379126
GO:0030201	heparan sulfate proteoglycan metabolic process	0.00626885419474033
GO:0030166	proteoglycan biosynthetic process	0.00928609767905773
GO:0006029	proteoglycan metabolic process	0.0110152288660697
GO:0007585	respiratory gaseous exchange	0.0110152288660697
GO:0004907	interleukin receptor activity	0.0118373341768045
GO:0019965	interleukin binding	0.0125316177331256
GO:0019221	cytokine and chemokine mediated signaling pathway	0.0125316177331256
GO:0044272	sulfur compound biosynthetic process	0.0125316177331256
GO:0008146	sulfotransferase activity	0.0135745195903601
GO:0016782	transferase activity, transferring sulfur-containing groups	0.0152307013251199
GO:0004896	hematopoietin/interferon-class (D200-domain) cytokine receptor activity	0.0160069626551084
GO:0006790	sulfur metabolic process	0.0185765203393453
GO:0019838	growth factor binding	0.0185765203393453
GO:0019955	cytokine binding	0.0196768804642845
GO:0043235	receptor complex	0.0208660349762662
GO:0016051	carbohydrate biosynthetic process	0.0250289063122503

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
leukocyte	4.12e-55	136
myeloid leukocyte	2.66e-53	72
hematopoietic stem cell	1.32e-49	168
angioblastic mesenchymal cell	1.32e-49	168
hematopoietic cell	1.95e-48	177
granulocyte monocyte progenitor cell	1.39e-47	67
myeloid cell	4.09e-47	108
common myeloid progenitor	4.09e-47	108
hematopoietic oligopotent progenitor cell	3.09e-46	161
hematopoietic multipotent progenitor cell	3.09e-46	161
classical monocyte	4.62e-44	42
CD14-positive, CD16-negative classical monocyte	4.62e-44	42
myeloid lineage restricted progenitor cell	1.93e-42	66
macrophage dendritic cell progenitor	3.93e-41	61
defensive cell	1.61e-40	48
phagocyte	1.61e-40	48
hematopoietic lineage restricted progenitor cell	4.56e-40	120
monopoietic cell	3.57e-39	59
monocyte	3.57e-39	59
monoblast	3.57e-39	59
promonocyte	3.57e-39	59
nongranular leukocyte	7.47e-37	115
stuff accumulating cell	1.62e-17	87
mesenchymal cell	2.43e-11	354
dendritic cell	4.46e-11	10
connective tissue cell	1.55e-10	361
granulocyte	4.24e-10	8
intermediate monocyte	5.60e-10	9
CD14-positive, CD16-positive monocyte	5.60e-10	9
conventional dendritic cell	2.88e-09	8
blood cell	2.95e-08	11
motile cell	8.02e-08	386
multi fate stem cell	1.53e-07	427
stem cell	1.81e-07	441
somatic stem cell	4.83e-07	433
immature conventional dendritic cell	7.43e-07	5
common dendritic progenitor	7.43e-07	5
histamine secreting cell	9.90e-07	5
biogenic amine secreting cell	9.90e-07	5
granulocytopoietic cell	9.90e-07	5
mast cell	9.90e-07	5
mast cell progenitor	9.90e-07	5
basophil mast progenitor cell	9.90e-07	5

Uber Anatomy

Ontology term	p-value	n
hemolymphoid system	2.94e-47	108
hematopoietic system	1.09e-45	98
blood island	1.09e-45	98
immune system	9.17e-42	93
bone marrow	2.66e-39	76
bone element	8.11e-35	82
skeletal element	8.36e-30	90
skeletal system	1.01e-24	100
lateral plate mesoderm	2.89e-21	203
musculoskeletal system	4.34e-10	167
connective tissue	7.27e-10	371
mesoderm	1.30e-07	315
mesoderm-derived structure	1.30e-07	315
presumptive mesoderm	1.30e-07	315

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.