Coexpression cluster:C4506

Full id: C4506_mesothelioma_schwannoma_Smooth_thyroid_leiomyoma_osteosarcoma_fibrous

Phase1 CAGE Peaks

Hg19::chr5:54281586..54281597,-	p5@ESM1
Hg19::chr5:54281688..54281697,-	p6@ESM1
Hg19::chr5:54281739..54281753,-	p3@ESM1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
mesodermal cell	1.74e-33	119
endothelial cell of vascular tree	1.20e-21	24
vascular associated smooth muscle cell	1.56e-19	32
muscle precursor cell	2.44e-18	57
myoblast	2.44e-18	57
multi-potent skeletal muscle stem cell	2.44e-18	57
endothelial cell	1.41e-17	35
non-terminally differentiated cell	2.85e-17	180
blood vessel endothelial cell	6.89e-17	18
embryonic blood vessel endothelial progenitor cell	6.89e-17	18
muscle cell	9.78e-17	54
lining cell	2.18e-16	57
barrier cell	2.18e-16	57
contractile cell	2.63e-16	59
smooth muscle cell	7.31e-15	42
smooth muscle myoblast	7.31e-15	42
electrically responsive cell	9.17e-14	60
electrically active cell	9.17e-14	60
meso-epithelial cell	9.08e-13	44
embryonic cell	2.95e-12	248
aortic smooth muscle cell	2.51e-10	10
endothelial cell of artery	2.25e-09	9
squamous epithelial cell	6.09e-07	62
smooth muscle cell of the subclavian artery	6.19e-07	5
fibroblast	6.43e-07	75
cardiocyte	8.82e-07	16

Uber Anatomy

Ontology term	p-value	n
vessel	2.84e-37	69
artery	1.89e-35	42
arterial blood vessel	1.89e-35	42
arterial system	1.89e-35	42
blood vessel	8.95e-34	60
epithelial tube open at both ends	8.95e-34	60
blood vasculature	8.95e-34	60
vascular cord	8.95e-34	60
splanchnic layer of lateral plate mesoderm	6.71e-30	84
systemic artery	1.15e-28	33
systemic arterial system	1.15e-28	33
vasculature	1.20e-28	79
vascular system	1.20e-28	79
epithelial tube	6.75e-25	118
cardiovascular system	1.44e-24	110
circulatory system	2.80e-23	113
unilaminar epithelium	7.78e-19	138
aorta	5.61e-17	21
aortic system	5.61e-17	21
endothelium	6.89e-17	18
blood vessel endothelium	6.89e-17	18
cardiovascular system endothelium	6.89e-17	18
skeletal muscle tissue	3.34e-16	61
striated muscle tissue	3.34e-16	61
myotome	3.34e-16	61
muscle tissue	3.01e-15	63
musculature	3.01e-15	63
musculature of body	3.01e-15	63
dermomyotome	4.95e-15	70
simple squamous epithelium	1.79e-14	22
multilaminar epithelium	2.58e-14	82
squamous epithelium	4.83e-13	25
anatomical conduit	1.10e-12	241
somite	1.38e-12	83
paraxial mesoderm	1.38e-12	83
presomitic mesoderm	1.38e-12	83
presumptive segmental plate	1.38e-12	83
trunk paraxial mesoderm	1.38e-12	83
presumptive paraxial mesoderm	1.38e-12	83
cell layer	1.63e-12	312
tube	1.63e-12	194
epithelium	1.67e-11	309
blood vessel smooth muscle	2.51e-10	10
arterial system smooth muscle	2.51e-10	10
artery smooth muscle tissue	2.51e-10	10
aorta smooth muscle tissue	2.51e-10	10
anatomical cluster	6.51e-10	286
endothelial tube	2.25e-09	9
arterial system endothelium	2.25e-09	9
endothelium of artery	2.25e-09	9
trunk mesenchyme	8.22e-09	143
trunk	6.74e-08	216
thoracic segment blood vessel	6.19e-07	5
subclavian artery	6.19e-07	5

Disease

Ontology term	p-value	n
ovarian cancer	8.64e-08	14

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.