Coexpression cluster:C167

Full id: C167_Basophils_Mast_Eosinophils_Neutrophils_Peripheral_Whole_CD4

Phase1 CAGE Peaks

Hg19::chr10:124304122..124304160,-	p@chr10:124304122..124304160 -
Hg19::chr11:128186999..128187003,+	p@chr11:128186999..128187003 +
Hg19::chr11:128199304..128199313,+	p@chr11:128199304..128199313 +
Hg19::chr11:128215284..128215295,-	p@chr11:128215284..128215295 -
Hg19::chr11:2961841..2961848,-	p@chr11:2961841..2961848 -
Hg19::chr11:63258372..63258390,-	p4@HRASLS5
Hg19::chr11:63259219..63259240,-	p@chr11:63259219..63259240 -
Hg19::chr11:78036624..78036637,-	p@chr11:78036624..78036637 -
Hg19::chr12:106663026..106663062,-	p@chr12:106663026..106663062 -
Hg19::chr12:12537737..12537747,+	p@chr12:12537737..12537747 +
Hg19::chr12:12592823..12592837,+	p@chr12:12592823..12592837 +
Hg19::chr12:89588335..89588344,-	p@chr12:89588335..89588344 -
Hg19::chr12:90154633..90154644,-	p@chr12:90154633..90154644 -
Hg19::chr12:93963739..93963750,+	p21@SOCS2
Hg19::chr12:93963755..93963796,+	p7@SOCS2
Hg19::chr12:93963797..93963817,+	p19@SOCS2
Hg19::chr12:93963818..93963840,+	p18@SOCS2
Hg19::chr13:100009628..100009669,-	p@chr13:100009628..100009669 -
Hg19::chr13:100009793..100009819,+	p@chr13:100009793..100009819 +
Hg19::chr13:49200434..49200436,+	p@chr13:49200434..49200436 +
Hg19::chr13:74039989..74040003,+	p@chr13:74039989..74040003 +
Hg19::chr14:52352999..52353029,+	p@chr14:52352999..52353029 +
Hg19::chr14:68086379..68086391,-	p@chr14:68086379..68086391 -
Hg19::chr14:75744139..75744151,+	p@chr14:75744139..75744151 +
Hg19::chr14:88462759..88462764,+	p@chr14:88462759..88462764 +
Hg19::chr14:88468930..88468934,-	p@chr14:88468930..88468934 -
Hg19::chr15:26341798..26341807,-	p@chr15:26341798..26341807 -
Hg19::chr15:45341008..45341013,-	p@chr15:45341008..45341013 -
Hg19::chr15:50645983..50645999,+	p10@LOC100129387
Hg19::chr16:17685400..17685426,+	p@chr16:17685400..17685426 +
Hg19::chr16:57723752..57723769,-	p@chr16:57723752..57723769 -
Hg19::chr16:57729090..57729104,-	p@chr16:57729090..57729104 -
Hg19::chr17:16342793..16342811,-	p@chr17:16342793..16342811 -
Hg19::chr17:504754..504779,-	p@chr17:504754..504779 -
Hg19::chr17:505873..505879,-	p@chr17:505873..505879 -
Hg19::chr17:505892..505911,-	p@chr17:505892..505911 -
Hg19::chr17:505912..505925,-	p@chr17:505912..505925 -
Hg19::chr17:62101666..62101672,-	p@chr17:62101666..62101672 -
Hg19::chr18:22040594..22040616,+	p1@HRH4
Hg19::chr18:22040620..22040632,+	p2@HRH4
Hg19::chr18:61557781..61557801,+	p4@SERPINB2
Hg19::chr18:61557821..61557826,+	p17@SERPINB2
Hg19::chr19:14117257..14117271,+	p@chr19:14117257..14117271 +
Hg19::chr19:14467251..14467255,-	p@chr19:14467251..14467255 -
Hg19::chr19:14895741..14895749,+	p@chr19:14895741..14895749 +
Hg19::chr19:39890344..39890356,+	p@chr19:39890344..39890356 +
Hg19::chr19:55850184..55850195,-	p@chr19:55850184..55850195 -
Hg19::chr1:110438839..110438854,+	p3@BC015716
Hg19::chr1:110438858..110438873,+	p2@BC015716
Hg19::chr1:110453244..110453259,-	p@chr1:110453244..110453259 -
Hg19::chr1:112016712..112016740,+	p4@C1orf162
Hg19::chr1:154720840..154720844,-	p@chr1:154720840..154720844 -
Hg19::chr1:212101868..212101870,+	p@chr1:212101868..212101870 +
Hg19::chr1:247712219..247712230,+	p5@C1orf150
Hg19::chr1:33608427..33608437,-	p2@uc001bxa.1
Hg19::chr1:33608449..33608459,-	p3@uc001bxa.1
Hg19::chr1:33608464..33608484,-	p1@uc001bxa.1
Hg19::chr1:33608559..33608582,+	p@chr1:33608559..33608582 +
Hg19::chr1:92021775..92021810,-	p@chr1:92021775..92021810 -
Hg19::chr1:94181180..94181200,-	p@chr1:94181180..94181200 -
Hg19::chr20:19213900..19213907,+	p@chr20:19213900..19213907 +
Hg19::chr20:34384754..34384772,+	p@chr20:34384754..34384772 +
Hg19::chr20:809889..809897,+	p@chr20:809889..809897 +
Hg19::chr20:810482..810511,+	p@chr20:810482..810511 +
Hg19::chr21:15957203..15957206,-	p@chr21:15957203..15957206 -
Hg19::chr22:37297434..37297455,-	p@chr22:37297434..37297455 -
Hg19::chr2:136971977..136971986,-	p@chr2:136971977..136971986 -
Hg19::chr2:137080332..137080340,+	p@chr2:137080332..137080340 +
Hg19::chr2:137085256..137085268,+	p@chr2:137085256..137085268 +
Hg19::chr2:28148771..28148776,-	p@chr2:28148771..28148776 -
Hg19::chr2:98547746..98547784,-	p@chr2:98547746..98547784 -
Hg19::chr3:112693690..112693718,-	p6@CD200R1
Hg19::chr3:112693763..112693777,-	p4@CD200R1
Hg19::chr3:128134414..128134423,+	p@chr3:128134414..128134423 +
Hg19::chr3:37187316..37187330,-	p@chr3:37187316..37187330 -
Hg19::chr3:53158080..53158100,-	p@chr3:53158080..53158100 -
Hg19::chr4:40200066..40200083,+	p@chr4:40200066..40200083 +
Hg19::chr4:47465894..47465904,+	p@chr4:47465894..47465904 +
Hg19::chr4:47475231..47475236,-	p@chr4:47475231..47475236 -
Hg19::chr4:47475237..47475246,-	p@chr4:47475237..47475246 -
Hg19::chr4:47477113..47477121,+	p@chr4:47477113..47477121 +
Hg19::chr4:47477135..47477138,+	p@chr4:47477135..47477138 +
Hg19::chr4:47487155..47487166,-	p@chr4:47487155..47487166 -
Hg19::chr4:47487179..47487194,-	p@chr4:47487179..47487194 -
Hg19::chr4:95479399..95479430,+	p@chr4:95479399..95479430 +
Hg19::chr5:132002498..132002502,+	p@chr5:132002498..132002502 +
Hg19::chr5:132010800..132010845,-	p@chr5:132010800..132010845 -
Hg19::chr5:156968826..156968831,-	p@chr5:156968826..156968831 -
Hg19::chr5:66188843..66188845,+	p@chr5:66188843..66188845 +
Hg19::chr5:68604322..68604336,+	p@chr5:68604322..68604336 +
Hg19::chr6:11393488..11393489,+	p@chr6:11393488..11393489 +
Hg19::chr6:138098041..138098086,-	p@chr6:138098041..138098086 -
Hg19::chr6:138098564..138098581,-	p@chr6:138098564..138098581 -
Hg19::chr6:147199372..147199389,-	p@chr6:147199372..147199389 -
Hg19::chr6:159084188..159084212,+	p4@SYTL3
Hg19::chr6:159096538..159096554,+	p@chr6:159096538..159096554 +
Hg19::chr7:128630152..128630186,-	p@chr7:128630152..128630186 -
Hg19::chr7:139418745..139418759,-	p@chr7:139418745..139418759 -
Hg19::chr7:139521206..139521224,-	p@chr7:139521206..139521224 -
Hg19::chr8:17931071..17931076,-	p@chr8:17931071..17931076 -
Hg19::chr8:38795967..38795993,-	p@chr8:38795967..38795993 -
Hg19::chr8:6875818..6875822,-	p1@DEFA1B p1@DEFA1 p1@DEFA3
Hg19::chr9:128592282..128592285,-	p@chr9:128592282..128592285 -
Hg19::chr9:5436322..5436331,+	p@chr9:5436322..5436331 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005148	prolactin receptor binding	0.0113009310155961
GO:0008269	JAK pathway signal transduction adaptor activity	0.0113009310155961
GO:0006916	anti-apoptosis	0.0113009310155961
GO:0008268	receptor signaling protein tyrosine kinase signaling protein activity	0.0113009310155961
GO:0043066	negative regulation of apoptosis	0.0113009310155961
GO:0043069	negative regulation of programmed cell death	0.0113009310155961
GO:0005131	growth hormone receptor binding	0.0113009310155961
GO:0008243	plasminogen activator activity	0.0123594836833995
GO:0005159	insulin-like growth factor receptor binding	0.0237179872861387
GO:0004969	histamine receptor activity	0.0237179872861387
GO:0042981	regulation of apoptosis	0.0384017062255695
GO:0043067	regulation of programmed cell death	0.0384017062255695
GO:0017137	Rab GTPase binding	0.0410050751701897

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
hematopoietic stem cell	5.54e-46	172
angioblastic mesenchymal cell	5.54e-46	172
hematopoietic oligopotent progenitor cell	1.71e-42	165
hematopoietic multipotent progenitor cell	1.71e-42	165
hematopoietic cell	1.86e-42	182
leukocyte	3.33e-38	140
hematopoietic lineage restricted progenitor cell	1.71e-31	124
myeloid cell	3.71e-31	112
common myeloid progenitor	3.71e-31	112
nongranular leukocyte	1.89e-27	119
myeloid leukocyte	9.19e-24	76
CD14-positive, CD16-negative classical monocyte	5.21e-22	42
classical monocyte	4.20e-20	45
granulocyte monocyte progenitor cell	6.03e-20	71
myeloid lineage restricted progenitor cell	9.01e-20	70
macrophage dendritic cell progenitor	1.15e-16	65
monopoietic cell	6.87e-16	63
monocyte	6.87e-16	63
monoblast	6.87e-16	63
promonocyte	6.87e-16	63
mesenchymal cell	1.27e-14	358
connective tissue cell	2.86e-13	365
motile cell	2.65e-11	390
lymphoid lineage restricted progenitor cell	7.15e-11	52
T cell	2.68e-10	25
pro-T cell	2.68e-10	25
lymphocyte	3.78e-10	53
common lymphoid progenitor	3.78e-10	53
mature alpha-beta T cell	3.05e-09	18
alpha-beta T cell	3.05e-09	18
immature T cell	3.05e-09	18
mature T cell	3.05e-09	18
immature alpha-beta T cell	3.05e-09	18
stem cell	3.54e-07	444
multi fate stem cell	3.80e-07	430
granulocyte	6.35e-07	8

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	4.43e-26	102
blood island	4.43e-26	102
hemolymphoid system	2.58e-22	112
bone marrow	9.07e-17	80
bone element	9.09e-16	86
immune system	2.51e-12	115
connective tissue	4.60e-12	375
skeletal element	4.48e-11	101
skeletal system	4.48e-11	101
blood	5.05e-10	15
haemolymphatic fluid	5.05e-10	15
organism substance	5.05e-10	15
adult organism	5.63e-08	115

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CEBPB#1051	29	2.22272385720115	2.21817983309706e-05	0.000485567980693407
EP300#2033	26	1.6934854315558	0.00420631548706538	0.0200265947827143
GATA1#2623	36	4.69395281900784	1.19822692849827e-15	2.23866944875547e-13
GATA2#2624	36	4.41170713853792	8.00898944190608e-15	1.39176513864098e-12
JUN#3725	17	2.04536631028575	0.00362349855384148	0.0183385620015822
JUND#3727	31	2.08494790575002	3.69567186075763e-05	0.000713838123665001
MAFK#7975	12	3.12700766974961	0.000468469941893346	0.00430161176906973
SIRT6#51548	4	5.90916938423173	0.00490827302647336	0.0229655986117043
SMARCA4#6597	7	10.5515511841848	5.24012715884766e-06	0.000160349733472866
STAT2#6773	6	3.7652175684485	0.00546247951274673	0.0247471434447472
TAL1#6886	19	5.4567665083785	1.78593193880806e-09	1.55304700880246e-07

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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