MCL coexpression mm9:3094

Phase1 CAGE Peaks

	Short description
Mm9::chr17:34136411..34136432,-	p2@H2-K1
Mm9::chr7:150813746..150813751,-	p1@Tnfrsf26
Mm9::chr7:150813813..150813868,-	p2@Tnfrsf26

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0019883	antigen processing and presentation of endogenous antigen	0.00379815018504548
GO:0002483	antigen processing and presentation of endogenous peptide antigen	0.00379815018504548
GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	0.00379815018504548
GO:0042612	MHC class I protein complex	0.0108202796308861
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	0.0108202796308861
GO:0042611	MHC protein complex	0.0128106795230008
GO:0048002	antigen processing and presentation of peptide antigen	0.013824746690577
GO:0019882	antigen processing and presentation	0.0202668944245671
GO:0009897	external side of plasma membrane	0.0428900342339228

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
hematopoietic cell	1.24e-11	32
hematopoietic oligopotent progenitor cell	1.24e-11	32
hematopoietic stem cell	1.24e-11	32
angioblastic mesenchymal cell	1.24e-11	32
hematopoietic multipotent progenitor cell	1.24e-11	32
connective tissue cell	3.25e-11	46
mesenchymal cell	3.25e-11	46
hematopoietic lineage restricted progenitor cell	1.23e-09	25
leukocyte	2.13e-09	17
nongranular leukocyte	2.13e-09	17
lymphoid lineage restricted progenitor cell	6.01e-09	12
T cell	2.43e-08	11
pro-T cell	2.43e-08	11
motile cell	3.37e-08	54
lymphocyte	1.41e-07	13
common lymphoid progenitor	1.41e-07	13
mature alpha-beta T cell	4.66e-07	9
alpha-beta T cell	4.66e-07	9
immature T cell	4.66e-07	9
mature T cell	4.66e-07	9
immature alpha-beta T cell	4.66e-07	9

Uber Anatomy

Ontology term	p-value	n
hemolymphoid system	5.51e-18	48
immune system	5.51e-18	48
hematopoietic system	1.26e-16	45
blood island	1.26e-16	45
lateral plate mesoderm	2.93e-12	87
connective tissue	3.25e-11	46
mixed endoderm/mesoderm-derived structure	4.27e-09	35
bone marrow	6.16e-09	16
hemopoietic organ	7.10e-09	29
immune organ	7.10e-09	29
musculoskeletal system	7.63e-09	32
mesoderm	9.00e-09	120
mesoderm-derived structure	9.00e-09	120
presumptive mesoderm	9.00e-09	120
foregut	5.53e-08	80
bone element	6.54e-08	22
skeletal element	6.54e-08	22
skeletal system	6.54e-08	22
segment of respiratory tract	1.73e-07	27
gland of gut	2.15e-07	24
thymus	2.78e-07	23
neck	2.78e-07	23
respiratory system epithelium	2.78e-07	23
hemolymphoid system gland	2.78e-07	23
pharyngeal epithelium	2.78e-07	23
thymic region	2.78e-07	23
pharyngeal gland	2.78e-07	23
entire pharyngeal arch endoderm	2.78e-07	23
thymus primordium	2.78e-07	23
early pharyngeal endoderm	2.78e-07	23

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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