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Coexpression cluster:C2196

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Full id: C2196_Basophils_Eosinophils_CD14_Peripheral_Neutrophils_immature_CD14CD16



Phase1 CAGE Peaks

Hg19::chr12:124875522..124875536,+p@chr12:124875522..124875536
+
Hg19::chr15:63795718..63795739,+p@chr15:63795718..63795739
+
Hg19::chr15:90931911..90931927,-p@chr15:90931911..90931927
-
Hg19::chr18:74777638..74777673,+p@chr18:74777638..74777673
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte5.90e-61136
hematopoietic stem cell4.84e-55168
angioblastic mesenchymal cell4.84e-55168
myeloid leukocyte2.16e-5372
hematopoietic cell2.25e-50177
hematopoietic oligopotent progenitor cell7.40e-50161
hematopoietic multipotent progenitor cell7.40e-50161
classical monocyte2.64e-4942
CD14-positive, CD16-negative classical monocyte2.64e-4942
hematopoietic lineage restricted progenitor cell2.31e-47120
granulocyte monocyte progenitor cell1.21e-4667
nongranular leukocyte2.77e-46115
defensive cell4.70e-4548
phagocyte4.70e-4548
macrophage dendritic cell progenitor5.30e-4361
myeloid cell6.41e-43108
common myeloid progenitor6.41e-43108
myeloid lineage restricted progenitor cell1.30e-4166
monopoietic cell7.43e-4159
monocyte7.43e-4159
monoblast7.43e-4159
promonocyte7.43e-4159
mesenchymal cell1.16e-27354
connective tissue cell2.56e-26361
motile cell2.77e-23386
stuff accumulating cell5.68e-1887
multi fate stem cell1.54e-17427
stem cell2.53e-17441
somatic stem cell3.30e-17433
intermediate monocyte1.92e-129
CD14-positive, CD16-positive monocyte1.92e-129
granulocyte2.39e-118
native cell4.64e-09722
somatic cell3.21e-08588
lymphoid lineage restricted progenitor cell5.92e-0852
lymphocyte1.15e-0753
common lymphoid progenitor1.15e-0753
blood cell1.39e-0711
nucleate cell3.96e-0755
Uber Anatomy
Ontology termp-valuen
hematopoietic system5.39e-4898
blood island5.39e-4898
bone marrow7.08e-4276
hemolymphoid system4.32e-41108
bone element3.27e-3782
immune system8.78e-3493
skeletal element5.44e-3290
skeletal system9.07e-28100
connective tissue3.89e-25371
lateral plate mesoderm2.88e-18203
mesoderm6.51e-11315
mesoderm-derived structure6.51e-11315
presumptive mesoderm6.51e-11315
musculoskeletal system1.55e-10167
blood6.93e-0815
haemolymphatic fluid6.93e-0815
organism substance6.93e-0815


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.443649
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.69331
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.11.68681
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.100363
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.12.66951
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.12.01976
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.11.08195
MA0146.10.221129
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.10559
MA0138.20.928035
MA0002.20.98779
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.551048
MA0065.20.577908
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.649108
MA0155.10.180766
MA0156.11.37856
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.309472
MA0163.10.918944
MA0164.10.90014
MA0080.21.32578
MA0018.20.870662
MA0099.21.85039
MA0079.20.00910927
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538318.26835134422770.0002681660105721290.00286663152283957
BCL11A#53335321.27709132770530.0001704839114606140.00208101557141597
EBF1#187948.9064668465690.00015887907472010.00199413191740086
FOS#235336.74846648167080.005032452776317940.02345625632641
JUN#372539.384621894252250.001918994502030470.0112822487501441
SPI1#668848.204323508522730.000220661881527680.00249142770214804



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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