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Coexpression cluster:C1390

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Full id: C1390_Mast_CD8_Natural_Basophils_CD34_CD4_CD19



Phase1 CAGE Peaks

Hg19::chr14:23025207..23025219,-p@chr14:23025207..23025219
-
Hg19::chr17:7743554..7743563,+p@chr17:7743554..7743563
+
Hg19::chr1:67519625..67519640,-p1@AB385301
Hg19::chr1:93812261..93812303,+p2@DR1
Hg19::chr4:76598434..76598445,-p6@G3BP2
Hg19::chr8:17780648..17780659,+p4@PCM1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0007253cytoplasmic sequestering of NF-kappaB0.0120973193800372
GO:0042347negative regulation of NF-kappaB import into nucleus0.0120973193800372
GO:0000242pericentriolar material0.0120973193800372
GO:0042994cytoplasmic sequestering of transcription factor0.0120973193800372
GO:0051220cytoplasmic sequestering of protein0.0120973193800372
GO:0042308negative regulation of protein import into nucleus0.0120973193800372
GO:0042992negative regulation of transcription factor import into nucleus0.0120973193800372
GO:0042345regulation of NF-kappaB import into nucleus0.0120973193800372
GO:0042348NF-kappaB import into nucleus0.0120973193800372
GO:0046823negative regulation of nucleocytoplasmic transport0.0120973193800372
GO:0051224negative regulation of protein transport0.0120973193800372
GO:0030159receptor signaling complex scaffold activity0.0120973193800372
GO:0032947protein complex scaffold0.0120973193800372
GO:0042990regulation of transcription factor import into nucleus0.0120973193800372
GO:0042991transcription factor import into nucleus0.0120973193800372
GO:0033157regulation of intracellular protein transport0.0120973193800372
GO:0042306regulation of protein import into nucleus0.0120973193800372
GO:0044450microtubule organizing center part0.0120973193800372
GO:0032507maintenance of cellular protein localization0.0120973193800372
GO:0051651maintenance of cellular localization0.0120973193800372
GO:0032386regulation of intracellular transport0.0120973193800372
GO:0045185maintenance of protein localization0.0120973193800372
GO:0051223regulation of protein transport0.012367641059904
GO:0046822regulation of nucleocytoplasmic transport0.012367641059904
GO:0051051negative regulation of transport0.0126910111404423
GO:0048523negative regulation of cellular process0.0146464428917892
GO:0048519negative regulation of biological process0.0149820926239023
GO:0051235maintenance of localization0.0149820926239023
GO:0051028mRNA transport0.0284818448587953
GO:0050658RNA transport0.0284818448587953
GO:0051236establishment of RNA localization0.0284818448587953
GO:0050657nucleic acid transport0.0284818448587953
GO:0006403RNA localization0.0284818448587953
GO:0006606protein import into nucleus0.0286006223338466
GO:0051170nuclear import0.0286006223338466
GO:0015931nucleobase, nucleoside, nucleotide and nucleic acid transport0.0295033620528052
GO:0003714transcription corepressor activity0.0295314200752571
GO:0051049regulation of transport0.0295578589690544
GO:0017038protein import0.0319304854904982
GO:0000122negative regulation of transcription from RNA polymerase II promoter0.032108983109937
GO:0005813centrosome0.032108983109937
GO:0007249I-kappaB kinase/NF-kappaB cascade0.0337643347359911
GO:0005815microtubule organizing center0.0348689724031423
GO:0006913nucleocytoplasmic transport0.0353498133259162
GO:0051169nuclear transport0.0353498133259162
GO:0045892negative regulation of transcription, DNA-dependent0.0449377503640029
GO:0005515protein binding0.0452836447329336
GO:0016564transcription repressor activity0.0452836447329336
GO:0006605protein targeting0.0452836447329336



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell7.65e-34172
angioblastic mesenchymal cell7.65e-34172
hematopoietic cell2.20e-31182
leukocyte1.27e-30140
hematopoietic oligopotent progenitor cell5.20e-30165
hematopoietic multipotent progenitor cell5.20e-30165
hematopoietic lineage restricted progenitor cell1.70e-24124
nongranular leukocyte2.79e-22119
lymphocyte5.50e-1653
common lymphoid progenitor5.50e-1653
lymphoid lineage restricted progenitor cell1.43e-1552
mesenchymal cell8.25e-15358
myeloid cell2.24e-14112
common myeloid progenitor2.24e-14112
connective tissue cell5.06e-14365
motile cell1.10e-11390
myeloid leukocyte1.42e-1076
T cell3.03e-1025
pro-T cell3.03e-1025
granulocyte monocyte progenitor cell9.40e-1071
multi fate stem cell2.93e-09430
myeloid lineage restricted progenitor cell4.12e-0970
stem cell1.21e-08444
mature alpha-beta T cell1.29e-0818
alpha-beta T cell1.29e-0818
immature T cell1.29e-0818
mature T cell1.29e-0818
immature alpha-beta T cell1.29e-0818
somatic stem cell3.57e-08436
macrophage dendritic cell progenitor1.51e-0765
monopoietic cell9.53e-0763
monocyte9.53e-0763
monoblast9.53e-0763
promonocyte9.53e-0763
Uber Anatomy
Ontology termp-valuen
hematopoietic system2.81e-15102
blood island2.81e-15102
connective tissue3.47e-13375
hemolymphoid system8.98e-13112
blood8.01e-0915
haemolymphatic fluid8.01e-0915
organism substance8.01e-0915
bone marrow5.19e-0880
bone element2.01e-0786
skeletal element8.19e-07101
skeletal system8.19e-07101


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL3#602211.51570093457940.01162725346801640.0424787044791744
GATA1#262336.780154071900220.006765763983348560.0287496795775466
GATA2#262436.3724658667770.008058821308742550.0318881275541321
SP1#666743.79892091876060.01052246616798510.0389452067516547
SREBF1#6720215.66861648016280.006411283165809460.0278902033719583
USF2#739236.49609869253480.007634319815300560.0314562167984446



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.