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Coexpression cluster:C1987

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Full id: C1987_CD14_cord_CD4_CD8_embryonic_Natural_CD19



Phase1 CAGE Peaks

Hg19::chr7:138748466..138748470,-p@chr7:138748466..138748470
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Hg19::chr7:138772774..138772778,-p@chr7:138772774..138772778
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Hg19::chr7:138779240..138779244,-p@chr7:138779240..138779244
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Hg19::chr7:138793014..138793017,-p@chr7:138793014..138793017
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Hg19::chr7:138794453..138794473,-p1@ZC3HAV1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell1.28e-52172
angioblastic mesenchymal cell1.28e-52172
hematopoietic cell5.06e-49182
hematopoietic oligopotent progenitor cell8.96e-49165
hematopoietic multipotent progenitor cell8.96e-49165
leukocyte6.15e-45140
hematopoietic lineage restricted progenitor cell7.81e-38124
nongranular leukocyte2.58e-37119
myeloid cell2.44e-25112
common myeloid progenitor2.44e-25112
lymphocyte7.20e-2253
common lymphoid progenitor7.20e-2253
lymphoid lineage restricted progenitor cell1.73e-2152
myeloid leukocyte1.49e-1876
myeloid lineage restricted progenitor cell1.26e-1670
granulocyte monocyte progenitor cell3.76e-1671
T cell4.16e-1425
pro-T cell4.16e-1425
monopoietic cell5.18e-1463
monocyte5.18e-1463
monoblast5.18e-1463
promonocyte5.18e-1463
macrophage dendritic cell progenitor8.01e-1465
classical monocyte2.62e-1345
CD14-positive, CD16-negative classical monocyte3.02e-1342
mature alpha-beta T cell3.41e-1118
alpha-beta T cell3.41e-1118
immature T cell3.41e-1118
mature T cell3.41e-1118
immature alpha-beta T cell3.41e-1118
mesenchymal cell1.49e-09358
connective tissue cell9.45e-09365
lymphocyte of B lineage2.53e-0724
pro-B cell2.53e-0724
B cell2.92e-0714
CD8-positive, alpha-beta T cell5.45e-0711
Uber Anatomy
Ontology termp-valuen
hematopoietic system3.87e-23102
blood island3.87e-23102
hemolymphoid system1.01e-21112
bone marrow9.07e-1480
bone element3.63e-1386
immune system9.56e-13115
skeletal element1.32e-09101
skeletal system1.32e-09101
connective tissue5.46e-09375
blood3.19e-0815
haemolymphatic fluid3.19e-0815
organism substance3.19e-0815
Disease
Ontology termp-valuen
hematologic cancer4.82e-1151
immune system cancer4.82e-1151
leukemia6.73e-0939


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.