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Coexpression cluster:C2151

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Full id: C2151_CD4_CD19_CD8_Whole_Dendritic_Neutrophils_Eosinophils



Phase1 CAGE Peaks

Hg19::chr11:64107543..64107574,-p@chr11:64107543..64107574
-
Hg19::chr16:30195531..30195557,+p@chr16:30195531..30195557
+
Hg19::chr16:30195571..30195586,+p@chr16:30195571..30195586
+
Hg19::chr16:3179653..3179678,-p@chr16:3179653..3179678
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell7.09e-58172
angioblastic mesenchymal cell7.09e-58172
leukocyte8.72e-55140
hematopoietic cell8.29e-54182
hematopoietic oligopotent progenitor cell3.12e-53165
hematopoietic multipotent progenitor cell3.12e-53165
nongranular leukocyte1.24e-44119
hematopoietic lineage restricted progenitor cell1.24e-44124
lymphocyte6.93e-3253
common lymphoid progenitor6.93e-3253
lymphoid lineage restricted progenitor cell1.80e-3152
myeloid cell3.88e-22112
common myeloid progenitor3.88e-22112
myeloid leukocyte5.51e-1876
T cell1.49e-1525
pro-T cell1.49e-1525
CD14-positive, CD16-negative classical monocyte1.51e-1542
lymphocyte of B lineage4.94e-1524
pro-B cell4.94e-1524
myeloid lineage restricted progenitor cell1.52e-1470
granulocyte monocyte progenitor cell3.43e-1471
macrophage dendritic cell progenitor1.25e-1365
mature alpha-beta T cell1.68e-1318
alpha-beta T cell1.68e-1318
immature T cell1.68e-1318
mature T cell1.68e-1318
immature alpha-beta T cell1.68e-1318
classical monocyte2.81e-1345
monopoietic cell4.36e-1363
monocyte4.36e-1363
monoblast4.36e-1363
promonocyte4.36e-1363
B cell8.75e-1014
CD8-positive, alpha-beta T cell5.38e-0911
mesenchymal cell2.70e-07358
Uber Anatomy
Ontology termp-valuen
hematopoietic system3.88e-23102
blood island3.88e-23102
hemolymphoid system3.73e-20112
adult organism1.46e-16115
bone marrow1.42e-1280
bone element7.02e-1186
blood6.71e-1015
haemolymphatic fluid6.71e-1015
organism substance6.71e-1015
immune system2.78e-08115
skeletal element1.99e-07101
skeletal system1.99e-07101
Disease
Ontology termp-valuen
hematologic cancer1.10e-1051
immune system cancer1.10e-1051
leukemia1.35e-0739


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#53335214.18472755180350.007108328585298740.0296137352554954
BCL3#602217.27355140186920.004834494208076070.022670157174805
EBF1#187936.679850134926750.005184294118278910.0240331347782383
ELF1#199744.258097958807540.003041525565781240.0160569119225915
GABPB1#255347.067683836182170.0004006876864423170.00389785965763311
IRF4#3662210.95725634337210.01174530180688030.0428171166675547
NFKB1#479045.488063424193840.001102199566301980.00766548714823282
PAX5#507946.669565531177830.0005052774169483260.00443115863201496
POU2F2#545236.829593043306890.004860473775203740.0227531609416631
SPI1#668848.204323508522730.000220661881527680.00249061993352095
TCF12#6938410.63446490218647.8163066689251e-050.00119889448112185
YY1#752844.911170749853860.00171871838055440.0106630170456648
ZEB1#6935312.66632401315790.000793336075912850.00612925184437507



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.