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Coexpression cluster:C3483

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Full id: C3483_Preadipocyte_Adipocyte_Ewing_Synoviocyte_Fibroblast_spindle_mesenchymal



Phase1 CAGE Peaks

Hg19::chr15:40212305..40212360,-p2@GPR176
Hg19::chr15:40212363..40212406,-p3@GPR176
Hg19::chr15:40212449..40212477,-p1@GPR176


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
epithelial vesicle1.10e-2278
multilaminar epithelium4.21e-2283
dense mesenchyme tissue4.39e-2273
somite5.87e-2271
presomitic mesoderm5.87e-2271
presumptive segmental plate5.87e-2271
dermomyotome5.87e-2271
trunk paraxial mesoderm5.87e-2271
paraxial mesoderm1.33e-2172
presumptive paraxial mesoderm1.33e-2172
skeletal muscle tissue3.81e-1862
striated muscle tissue3.81e-1862
myotome3.81e-1862
splanchnic layer of lateral plate mesoderm4.49e-1883
vasculature8.27e-1878
vascular system8.27e-1878
muscle tissue4.43e-1764
musculature4.43e-1764
musculature of body4.43e-1764
vessel2.04e-1668
artery2.10e-1642
arterial blood vessel2.10e-1642
arterial system2.10e-1642
mesenchyme2.21e-16160
entire embryonic mesenchyme2.21e-16160
unilaminar epithelium3.30e-16148
epithelial tube open at both ends3.84e-1659
blood vessel3.84e-1659
blood vasculature3.84e-1659
vascular cord3.84e-1659
trunk mesenchyme7.99e-16122
organism subdivision4.25e-15264
epithelial tube1.09e-14117
cell layer1.41e-14309
epithelium3.36e-14306
cardiovascular system6.69e-14109
systemic artery8.14e-1433
systemic arterial system8.14e-1433
surface structure9.85e-1499
circulatory system2.60e-13112
multi-cellular organism1.26e-12656
trunk2.65e-12199
multi-tissue structure7.38e-12342
integument6.21e-1146
integumental system6.21e-1146
anatomical cluster1.97e-10373
anatomical system3.38e-10624
skin of body5.08e-1041
anatomical group5.75e-10625
anatomical conduit2.34e-08240
aorta2.46e-0821
aortic system2.46e-0821
organ component layer1.65e-0766


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066435.360256373075030.0064925092527670.0278961276113767
E2F1#186934.907389214879320.008460985347239390.0324480170631342
MAX#414936.452555509007120.003721913834265510.018619196193747
ZNF263#1012738.221841637010680.001799043925565870.0109156073050703



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.