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Coexpression cluster:C706

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Full id: C706_Adipocyte_Preadipocyte_tenocyte_leiomyoma_chorionic_Olfactory_Hair



Phase1 CAGE Peaks

Hg19::chr17:76850062..76850090,-p@chr17:76850062..76850090
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Hg19::chr17:76850123..76850137,-p@chr17:76850123..76850137
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Hg19::chr17:76850216..76850253,-p8@TIMP2
Hg19::chr17:76850381..76850397,-p3@TIMP2
Hg19::chr17:76850613..76850641,-p5@TIMP2
Hg19::chr17:76850688..76850705,-p9@TIMP2
Hg19::chr17:76851239..76851259,-p4@TIMP2
Hg19::chr17:76851266..76851308,-p6@TIMP2
Hg19::chr17:76851469..76851493,-p@chr17:76851469..76851493
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Hg19::chr17:76851547..76851576,-p@chr17:76851547..76851576
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Hg19::chr17:76851684..76851703,-p@chr17:76851684..76851703
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Hg19::chr17:76853697..76853720,-p@chr17:76853697..76853720
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
multi-cellular organism3.41e-14656
mesoderm7.12e-13315
mesoderm-derived structure7.12e-13315
presumptive mesoderm7.12e-13315
anatomical system2.55e-12624
anatomical group3.70e-12625
epithelial vesicle2.52e-1178
dense mesenchyme tissue7.38e-1173
paraxial mesoderm1.76e-1072
presumptive paraxial mesoderm1.76e-1072
somite2.23e-1071
presomitic mesoderm2.23e-1071
presumptive segmental plate2.23e-1071
dermomyotome2.23e-1071
trunk paraxial mesoderm2.23e-1071
trunk mesenchyme2.54e-10122
muscle tissue9.61e-1064
musculature9.61e-1064
musculature of body9.61e-1064
skeletal muscle tissue1.39e-0962
striated muscle tissue1.39e-0962
myotome1.39e-0962
mesenchyme2.32e-09160
entire embryonic mesenchyme2.32e-09160
vasculature3.45e-0878
vascular system3.45e-0878
splanchnic layer of lateral plate mesoderm7.64e-0883
multilaminar epithelium1.58e-0783
germ layer1.88e-07560
germ layer / neural crest1.88e-07560
embryonic tissue1.88e-07560
presumptive structure1.88e-07560
germ layer / neural crest derived structure1.88e-07560
epiblast (generic)1.88e-07560
vessel3.99e-0768
embryonic structure4.55e-07564
integument6.95e-0746
integumental system6.95e-0746
organ7.22e-07503


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
GATA2#262444.248310577851330.01122661586864120.0412212253798697
TAL1#688649.956205559146730.0005005618117785480.00441203266607644



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.