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Coexpression cluster:C2781

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Full id: C2781_heart_Endothelial_mesenchymal_Myoblast_Preadipocyte_Cardiac_Synoviocyte



Phase1 CAGE Peaks

Hg19::chr4:159092525..159092574,-p4@FAM198B
Hg19::chr4:159092576..159092617,-p8@FAM198B
Hg19::chr4:159092626..159092672,-p6@FAM198B
Hg19::chr4:159092677..159092708,-p9@FAM198B


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
mesoderm1.97e-28315
mesoderm-derived structure1.97e-28315
presumptive mesoderm1.97e-28315
multi-cellular organism4.22e-19656
lateral plate mesoderm2.66e-18203
splanchnic layer of lateral plate mesoderm9.10e-1883
anatomical system5.65e-16624
anatomical group9.04e-16625
circulatory system4.43e-14112
tissue6.57e-14773
adult organism8.27e-14114
germ layer3.80e-13560
germ layer / neural crest3.80e-13560
embryonic tissue3.80e-13560
presumptive structure3.80e-13560
germ layer / neural crest derived structure3.80e-13560
epiblast (generic)3.80e-13560
embryonic structure6.13e-13564
cardiovascular system7.42e-13109
vessel1.14e-1268
primary circulatory organ4.84e-1227
epithelial tube open at both ends2.14e-1159
blood vessel2.14e-1159
blood vasculature2.14e-1159
vascular cord2.14e-1159
developing anatomical structure2.66e-11581
embryo1.04e-10592
epithelial tube1.22e-10117
heart1.88e-1024
primitive heart tube1.88e-1024
primary heart field1.88e-1024
anterior lateral plate mesoderm1.88e-1024
heart tube1.88e-1024
heart primordium1.88e-1024
cardiac mesoderm1.88e-1024
cardiogenic plate1.88e-1024
heart rudiment1.88e-1024
vasculature2.30e-1078
vascular system2.30e-1078
blood vessel endothelium2.38e-1018
endothelium2.38e-1018
cardiovascular system endothelium2.38e-1018
musculoskeletal system5.15e-09167
anatomical conduit9.01e-09240
squamous epithelium1.17e-0825
tube2.12e-08192
simple squamous epithelium3.12e-0822
muscle tissue9.55e-0764
musculature9.55e-0764
musculature of body9.55e-0764
compound organ9.61e-0768


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
FOS#235348.99795530889440.0001525147711168630.00195273877414173
GATA2#2624412.7449317335543.78864877853583e-050.000723765666327975



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.