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Coexpression cluster:C4392

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Full id: C4392_Mammary_Burkitt_pharyngeal_Keratinocyte_Sebocyte_Corneal_salivary



Phase1 CAGE Peaks

Hg19::chr4:169575836..169575859,+p24@PALLD
Hg19::chr4:169575875..169575902,+p12@PALLD
Hg19::chr4:169575903..169575919,+p22@PALLD


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
respiratory system3.00e-2674
endoderm-derived structure5.61e-26160
endoderm5.61e-26160
presumptive endoderm5.61e-26160
digestive system1.73e-25145
digestive tract1.73e-25145
primitive gut1.73e-25145
subdivision of digestive tract5.81e-23118
segment of respiratory tract1.93e-2047
respiratory tract9.92e-2054
respiratory primordium2.39e-1838
endoderm of foregut2.39e-1838
foregut3.77e-1887
upper respiratory tract4.72e-1519
larynx1.09e-139
organ segment5.52e-1298
oral opening1.32e-1122
thoracic cavity element6.50e-1034
thoracic cavity6.50e-1034
respiratory system epithelium1.51e-0928
mouth1.52e-0929
stomodeum1.52e-0929
thoracic segment organ1.64e-0935
gland of gut2.37e-0910
orifice6.68e-0936
epithelial bud9.51e-0937
saliva-secreting gland1.06e-086
gland of oral region1.06e-086
gland of foregut1.06e-086
oral gland1.06e-086
oral cavity1.06e-086
mammary gland1.25e-084
mammary bud1.25e-084
mammary ridge1.25e-084
mammary placode1.25e-084
epithelial fold3.12e-0847
organ system subdivision5.57e-08223
surface structure6.04e-0899
thoracic segment of trunk1.10e-0752
organ3.07e-07503
endo-epithelium3.67e-0782
anterior region of body4.24e-0762
craniocervical region4.24e-0762
primordium4.72e-07160
intestine8.32e-0717
Disease
Ontology termp-valuen
carcinoma2.01e-14106
squamous cell carcinoma3.06e-0914
cell type cancer8.01e-09143


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.