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Coexpression cluster:C1577

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Full id: C1577_Mast_CD4_CD34_CD8_Natural_CD14_immature



Phase1 CAGE Peaks

Hg19::chr10:3916381..3916422,+p@chr10:3916381..3916422
+
Hg19::chr11:66384629..66384643,+p6@RBM14
Hg19::chr3:107941436..107941490,+p@chr3:107941436..107941490
+
Hg19::chr3:32543733..32543758,+p@chr3:32543733..32543758
+
Hg19::chr5:672925..672969,-p@chr5:672925..672969
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte5.40e-41140
hematopoietic stem cell1.35e-37172
angioblastic mesenchymal cell1.35e-37172
hematopoietic lineage restricted progenitor cell7.26e-35124
hematopoietic cell1.25e-34182
hematopoietic oligopotent progenitor cell3.72e-34165
hematopoietic multipotent progenitor cell3.72e-34165
nongranular leukocyte7.36e-32119
CD14-positive, CD16-negative classical monocyte2.10e-2042
lymphoid lineage restricted progenitor cell1.71e-1952
lymphocyte1.86e-1953
common lymphoid progenitor1.86e-1953
classical monocyte3.11e-1845
myeloid leukocyte1.05e-1576
granulocyte monocyte progenitor cell1.92e-1571
myeloid cell2.42e-15112
common myeloid progenitor2.42e-15112
myeloid lineage restricted progenitor cell2.04e-1470
mesenchymal cell4.07e-14358
connective tissue cell1.44e-13365
macrophage dendritic cell progenitor1.30e-1265
motile cell8.66e-12390
monopoietic cell1.33e-1163
monocyte1.33e-1163
monoblast1.33e-1163
promonocyte1.33e-1163
mature alpha-beta T cell6.42e-1118
alpha-beta T cell6.42e-1118
immature T cell6.42e-1118
mature T cell6.42e-1118
immature alpha-beta T cell6.42e-1118
T cell3.67e-1025
pro-T cell3.67e-1025
stem cell8.67e-10444
somatic stem cell2.29e-09436
multi fate stem cell2.32e-09430
lymphocyte of B lineage1.08e-0824
pro-B cell1.08e-0824
B cell4.86e-0814
CD8-positive, alpha-beta T cell1.77e-0711
intermediate monocyte8.66e-079
CD14-positive, CD16-positive monocyte8.66e-079
Uber Anatomy
Ontology termp-valuen
hematopoietic system6.73e-20102
blood island6.73e-20102
hemolymphoid system2.39e-18112
bone marrow1.19e-1580
bone element1.91e-1486
connective tissue6.58e-14375
skeletal element9.47e-10101
skeletal system9.47e-10101
immune system1.22e-09115


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.