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Coexpression cluster:C1947

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Full id: C1947_Smooth_synovial_small_gastric_parietal_Cardiac_acute



Phase1 CAGE Peaks

Hg19::chr5:1041879..1041917,+p@chr5:1041879..1041917
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Hg19::chr5:1042544..1042553,+p@chr5:1042544..1042553
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Hg19::chr5:1043105..1043109,+p@chr5:1043105..1043109
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Hg19::chr5:1043617..1043642,+p@chr5:1043617..1043642
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Hg19::chr5:1045108..1045137,+p@chr5:1045108..1045137
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
gray matter5.15e-2034
brain grey matter5.15e-2034
neural tube7.55e-1957
neural rod7.55e-1957
future spinal cord7.55e-1957
neural keel7.55e-1957
adult organism1.03e-18115
telencephalon3.64e-1834
cerebral hemisphere5.02e-1832
regional part of telencephalon3.36e-1733
regional part of cerebral cortex3.80e-1622
brain1.27e-1569
future brain1.27e-1569
regional part of brain2.43e-1559
cerebral cortex4.10e-1525
pallium4.10e-1525
regional part of forebrain4.15e-1541
forebrain4.15e-1541
future forebrain4.15e-1541
anterior neural tube1.44e-1442
central nervous system2.06e-1482
neocortex8.86e-1420
neurectoderm4.38e-1390
neural plate2.36e-1286
presumptive neural plate2.36e-1286
regional part of nervous system1.27e-1194
nervous system1.27e-1194
tube1.26e-09194
anterior region of body1.32e-09129
craniocervical region1.32e-09129
pre-chordal neural plate2.18e-0961
anatomical conduit3.70e-09241
anatomical cluster8.11e-09286
gyrus1.81e-086
head3.02e-08123
parietal lobe1.44e-075
brainstem4.66e-078


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL3#602320.7282616822430.0002320005217689230.00255078455553474



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.