Coexpression cluster:C4561

Full id: C4561_mesenchymal_Preadipocyte_tenocyte_Fibroblast_Pancreatic_Neural_Smooth

Phase1 CAGE Peaks

Hg19::chr6:132722586..132722598,-	p2@MOXD1
Hg19::chr6:132722599..132722600,-	p3@MOXD1
Hg19::chr6:132722604..132722670,-	p1@MOXD1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
fibroblast	6.48e-17	76
skin fibroblast	9.36e-13	23
non-terminally differentiated cell	2.05e-12	106
electrically responsive cell	4.45e-11	61
electrically active cell	4.45e-11	61
contractile cell	6.60e-11	59
muscle precursor cell	6.61e-11	58
myoblast	6.61e-11	58
multi-potent skeletal muscle stem cell	6.61e-11	58
muscle cell	1.04e-10	55
smooth muscle cell	2.14e-09	43
smooth muscle myoblast	2.14e-09	43

Uber Anatomy

Ontology term	p-value	n
multi-tissue structure	7.08e-16	342
dense mesenchyme tissue	5.71e-13	73
paraxial mesoderm	9.38e-13	72
presumptive paraxial mesoderm	9.38e-13	72
somite	1.71e-12	71
presomitic mesoderm	1.71e-12	71
presumptive segmental plate	1.71e-12	71
dermomyotome	1.71e-12	71
trunk paraxial mesoderm	1.71e-12	71
surface structure	5.07e-12	99
integument	5.09e-12	46
integumental system	5.09e-12	46
mesenchyme	8.49e-12	160
entire embryonic mesenchyme	8.49e-12	160
epithelial vesicle	1.98e-11	78
structure with developmental contribution from neural crest	2.80e-11	132
cerebral hemisphere	7.17e-11	32
multi-cellular organism	1.76e-10	656
muscle tissue	2.35e-10	64
musculature	2.35e-10	64
musculature of body	2.35e-10	64
skin of body	2.41e-10	41
ectoderm-derived structure	2.65e-10	171
ectoderm	2.65e-10	171
presumptive ectoderm	2.65e-10	171
telencephalon	2.71e-10	34
skeletal muscle tissue	5.76e-10	62
striated muscle tissue	5.76e-10	62
myotome	5.76e-10	62
multilaminar epithelium	5.76e-10	83
regional part of telencephalon	8.15e-10	32
cerebral cortex	8.60e-10	25
pallium	8.60e-10	25
anatomical system	1.01e-09	624
anatomical group	1.54e-09	625
anatomical cluster	3.05e-09	373
pre-chordal neural plate	3.10e-09	61
regional part of forebrain	5.10e-09	41
forebrain	5.10e-09	41
anterior neural tube	5.10e-09	41
future forebrain	5.10e-09	41
brain grey matter	6.58e-09	34
gray matter	6.58e-09	34
tissue	1.10e-08	773
trunk mesenchyme	1.21e-08	122
epithelium	3.28e-08	306
regional part of cerebral cortex	5.10e-08	22
organism subdivision	5.45e-08	264
organ part	5.70e-08	218
cell layer	8.34e-08	309
central nervous system	2.02e-07	81
neocortex	2.23e-07	20
neural plate	4.11e-07	82
presumptive neural plate	4.11e-07	82
organ component layer	4.38e-07	66

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CTCF#10664	3	5.36025637307503	0.006492509252767	0.0281042472686092
ZNF263#10127	3	8.22184163701068	0.00179904392556587	0.0109999618606741

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.