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Coexpression cluster:C730: Difference between revisions

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{{Coexpression_clusters
{{Coexpression_clusters
|coexpression_dpi_cluster_scores_median=0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.44051683339664,0.484657769211849,0.44876009648442,0,0,0,0,0,0,0,0.057730457053664,0,0.191449731291012,0.146465690858417,0.27138698118093,0,0,0,0,0,0,0,0,0,0,0.0990452042849908,0.092187879276543,0,0.216293844171574,0,0,0,0,0,0.120879483793741,0.214668274387199,0,0,0,0.198772098536566,0.195175748476722,0.210270953277894,0,0,0,0,0.136174228629411,0.355231069747725,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.200641830559455,0.140593896684098,0,0,0,0,0,0,0,0,0,0,0.0873628578078838,0,0,0,0.0523442574910016,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.102927476286267,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0697160876101768,0.0542137952531537,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.326510248395875,0,0,0.052441152940763,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.105947296040957,0,0,0.454276412974832,0,0,0,0,0.0408567533019575,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1.31324262054528,0.912047052104705,0.815203278460504,0,0,0,0,0,0,0,0,0,0,0.060819961675157,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.183490411696814,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0352989626615976,0,0,0,0,0,0.59380210434493,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.078316005475075,0.0499125701957491,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1.22488732040258,1.01842601030509,1.05949469898915,0,0,0,0.301016310671738,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.435925520102053,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0748046823502985,0.0271284845789754,0.476950850245858,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0839445661171913,0,0.0271819376754428,0.0963185729165539,0,0,0,0,0,0.12605352776203,0,0,0,0,0,0,0,0,0,0,0,0.465889869901082
|full_id=C730_migratory_cord_Mast_B_b_CD14_CD19
|full_id=C730_migratory_cord_Mast_B_b_CD14_CD19
|gostat_on_coexpression_clusters=GO:0006916!anti-apoptosis!0.00846701689959302!330;7128$GO:0045627!positive regulation of T-helper 1 cell differentiation!0.00846701689959302!941$GO:0043066!negative regulation of apoptosis!0.00846701689959302!330;7128$GO:0043069!negative regulation of programmed cell death!0.00846701689959302!330;7128$GO:0045425!positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process!0.00846701689959302!941$GO:0045625!regulation of T-helper 1 cell differentiation!0.00846701689959302!941$GO:0045624!positive regulation of T-helper cell differentiation!0.00846701689959302!941$GO:0045423!regulation of granulocyte macrophage colony-stimulating factor biosynthetic process!0.00846701689959302!941$GO:0045063!T-helper 1 cell differentiation!0.00846701689959302!941$GO:0048869!cellular developmental process!0.00846701689959302!330;7128;941$GO:0030154!cell differentiation!0.00846701689959302!330;7128;941$GO:0032604!granulocyte macrophage colony-stimulating factor production!0.00846701689959302!941$GO:0042253!granulocyte macrophage colony-stimulating factor biosynthetic process!0.00846701689959302!941$GO:0043124!negative regulation of I-kappaB kinase/NF-kappaB cascade!0.0088037535985753!7128$GO:0050794!regulation of cellular process!0.0088037535985753!330;7128;941;27086$GO:0045622!regulation of T-helper cell differentiation!0.0088037535985753!941$GO:0050789!regulation of biological process!0.0088037535985753!330;7128;941;27086$GO:0002294!CD4-positive, alpha-beta T cell differentiation during immune response!0.0088037535985753!941$GO:0002292!T cell differentiation during immune response!0.0088037535985753!941$GO:0042093!T-helper cell differentiation!0.0088037535985753!941$GO:0002366!leukocyte activation during immune response!0.0088037535985753!941$GO:0002285!lymphocyte activation during immune response!0.0088037535985753!941$GO:0002293!alpha-beta T cell differentiation during immune response!0.0088037535985753!941$GO:0002286!T cell activation during immune response!0.0088037535985753!941$GO:0002263!cell activation during immune response!0.0088037535985753!941$GO:0043367!CD4-positive, alpha beta T cell differentiation!0.00896639012394077!941$GO:0045086!positive regulation of interleukin-2 biosynthetic process!0.00896639012394077!941$GO:0042088!T-helper 1 type immune response!0.00943176012279184!941$GO:0065007!biological regulation!0.00993040632193333!330;7128;941;27086$GO:0042981!regulation of apoptosis!0.0100587672340465!330;7128$GO:0043067!regulation of programmed cell death!0.0100587672340465!330;7128$GO:0045076!regulation of interleukin-2 biosynthetic process!0.0100587672340465!941$GO:0015026!coreceptor activity!0.0100587672340465!941$GO:0042094!interleukin-2 biosynthetic process!0.0100587672340465!941$GO:0046632!alpha-beta T cell differentiation!0.0100587672340465!941$GO:0050731!positive regulation of peptidyl-tyrosine phosphorylation!0.0103901080152437!941$GO:0046631!alpha-beta T cell activation!0.0112976251774761!941$GO:0032623!interleukin-2 production!0.0121571738180355!941$GO:0042327!positive regulation of phosphorylation!0.0129724438466746!941$GO:0045937!positive regulation of phosphate metabolic process!0.0136838464624472!941$GO:0001934!positive regulation of protein amino acid phosphorylation!0.0136838464624472!941$GO:0033240!positive regulation of amine metabolic process!0.0136838464624472!941$GO:0045764!positive regulation of amino acid metabolic process!0.0136838464624472!941$GO:0009966!regulation of signal transduction!0.0136838464624472!7128;941$GO:0050730!regulation of peptidyl-tyrosine phosphorylation!0.0136838464624472!941$GO:0032502!developmental process!0.0143908452919003!330;7128;941$GO:0006915!apoptosis!0.0145299318049594!330;7128$GO:0012501!programmed cell death!0.0145299318049594!330;7128$GO:0008219!cell death!0.0154497464175671!330;7128$GO:0016265!death!0.0154497464175671!330;7128$GO:0042108!positive regulation of cytokine biosynthetic process!0.0173298119070996!941$GO:0030217!T cell differentiation!0.0173298119070996!941$GO:0018108!peptidyl-tyrosine phosphorylation!0.017416768372748!941$GO:0018212!peptidyl-tyrosine modification!0.0177337429088587!941$GO:0001932!regulation of protein amino acid phosphorylation!0.0177337429088587!941$GO:0033238!regulation of amine metabolic process!0.0177337429088587!941$GO:0006521!regulation of amino acid metabolic process!0.0177337429088587!941$GO:0045727!positive regulation of translation!0.0200738668320086!941$GO:0048523!negative regulation of cellular process!0.0203475436230452!330;7128$GO:0008270!zinc ion binding!0.0207769642665428!330;7128;27086$GO:0048519!negative regulation of biological process!0.0209150828709926!330;7128$GO:0042035!regulation of cytokine biosynthetic process!0.0209150828709926!941$GO:0031328!positive regulation of cellular biosynthetic process!0.0209150828709926!941$GO:0042325!regulation of phosphorylation!0.0216146228805791!941$GO:0030098!lymphocyte differentiation!0.0216146228805791!941$GO:0048468!cell development!0.0216146228805791!330;7128$GO:0042089!cytokine biosynthetic process!0.021638507126761!941$GO:0042107!cytokine metabolic process!0.021638507126761!941$GO:0051174!regulation of phosphorus metabolic process!0.021638507126761!941$GO:0019220!regulation of phosphate metabolic process!0.021638507126761!941$GO:0009891!positive regulation of biosynthetic process!0.0216419680822234!941$GO:0002250!adaptive immune response!0.0228471846603561!941$GO:0002460!adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains!0.0228471846603561!941$GO:0051247!positive regulation of protein metabolic process!0.0251974450950482!941$GO:0002521!leukocyte differentiation!0.0263181054783823!941$GO:0046914!transition metal ion binding!0.0263418696564084!330;7128;27086$GO:0042110!T cell activation!0.0279032791360802!941$GO:0009968!negative regulation of signal transduction!0.0290930201859787!7128$GO:0007165!signal transduction!0.0290930201859787!330;7128;941$GO:0043122!regulation of I-kappaB kinase/NF-kappaB cascade!0.0295843340928558!7128$GO:0001816!cytokine production!0.030565078760423!941$GO:0018193!peptidyl-amino acid modification!0.0323184193172839!941$GO:0007154!cell communication!0.0346449739125504!330;7128;941$GO:0007249!I-kappaB kinase/NF-kappaB cascade!0.0362133505252718!7128$GO:0045595!regulation of cell differentiation!0.0370664343864876!941$GO:0009967!positive regulation of signal transduction!0.038909666557327!941$GO:0046649!lymphocyte activation!0.0389617623384476!941$GO:0007242!intracellular signaling cascade!0.039422872973318!7128;941$GO:0030097!hemopoiesis!0.0395500346220457!941$GO:0004842!ubiquitin-protein ligase activity!0.0398340772845374!330$GO:0008639!small protein conjugating enzyme activity!0.0398732590749438!330$GO:0005634!nucleus!0.0399241594957774!330;7128;27086$GO:0048534!hemopoietic or lymphoid organ development!0.0406484365205676!941$GO:0045321!leukocyte activation!0.041830301086174!941$GO:0002520!immune system development!0.0418461718831951!941$GO:0006417!regulation of translation!0.0418616318815704!941$GO:0031326!regulation of cellular biosynthetic process!0.0447778243296604!941$GO:0043687!post-translational protein modification!0.0452550749111929!7128;941$GO:0043169!cation binding!0.0452550749111929!330;7128;27086$GO:0001775!cell activation!0.045596969066149!941$GO:0009889!regulation of biosynthetic process!0.046856999686847!941
|gostat_on_coexpression_clusters=GO:0006916!anti-apoptosis!0.00846701689959302!330;7128$GO:0045627!positive regulation of T-helper 1 cell differentiation!0.00846701689959302!941$GO:0043066!negative regulation of apoptosis!0.00846701689959302!330;7128$GO:0043069!negative regulation of programmed cell death!0.00846701689959302!330;7128$GO:0045425!positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process!0.00846701689959302!941$GO:0045625!regulation of T-helper 1 cell differentiation!0.00846701689959302!941$GO:0045624!positive regulation of T-helper cell differentiation!0.00846701689959302!941$GO:0045423!regulation of granulocyte macrophage colony-stimulating factor biosynthetic process!0.00846701689959302!941$GO:0045063!T-helper 1 cell differentiation!0.00846701689959302!941$GO:0048869!cellular developmental process!0.00846701689959302!330;7128;941$GO:0030154!cell differentiation!0.00846701689959302!330;7128;941$GO:0032604!granulocyte macrophage colony-stimulating factor production!0.00846701689959302!941$GO:0042253!granulocyte macrophage colony-stimulating factor biosynthetic process!0.00846701689959302!941$GO:0043124!negative regulation of I-kappaB kinase/NF-kappaB cascade!0.0088037535985753!7128$GO:0050794!regulation of cellular process!0.0088037535985753!330;7128;941;27086$GO:0045622!regulation of T-helper cell differentiation!0.0088037535985753!941$GO:0050789!regulation of biological process!0.0088037535985753!330;7128;941;27086$GO:0002294!CD4-positive, alpha-beta T cell differentiation during immune response!0.0088037535985753!941$GO:0002292!T cell differentiation during immune response!0.0088037535985753!941$GO:0042093!T-helper cell differentiation!0.0088037535985753!941$GO:0002366!leukocyte activation during immune response!0.0088037535985753!941$GO:0002285!lymphocyte activation during immune response!0.0088037535985753!941$GO:0002293!alpha-beta T cell differentiation during immune response!0.0088037535985753!941$GO:0002286!T cell activation during immune response!0.0088037535985753!941$GO:0002263!cell activation during immune response!0.0088037535985753!941$GO:0043367!CD4-positive, alpha beta T cell differentiation!0.00896639012394077!941$GO:0045086!positive regulation of interleukin-2 biosynthetic process!0.00896639012394077!941$GO:0042088!T-helper 1 type immune response!0.00943176012279184!941$GO:0065007!biological regulation!0.00993040632193333!330;7128;941;27086$GO:0042981!regulation of apoptosis!0.0100587672340465!330;7128$GO:0043067!regulation of programmed cell death!0.0100587672340465!330;7128$GO:0045076!regulation of interleukin-2 biosynthetic process!0.0100587672340465!941$GO:0015026!coreceptor activity!0.0100587672340465!941$GO:0042094!interleukin-2 biosynthetic process!0.0100587672340465!941$GO:0046632!alpha-beta T cell differentiation!0.0100587672340465!941$GO:0050731!positive regulation of peptidyl-tyrosine phosphorylation!0.0103901080152437!941$GO:0046631!alpha-beta T cell activation!0.0112976251774761!941$GO:0032623!interleukin-2 production!0.0121571738180355!941$GO:0042327!positive regulation of phosphorylation!0.0129724438466746!941$GO:0045937!positive regulation of phosphate metabolic process!0.0136838464624472!941$GO:0001934!positive regulation of protein amino acid phosphorylation!0.0136838464624472!941$GO:0033240!positive regulation of amine metabolic process!0.0136838464624472!941$GO:0045764!positive regulation of amino acid metabolic process!0.0136838464624472!941$GO:0009966!regulation of signal transduction!0.0136838464624472!7128;941$GO:0050730!regulation of peptidyl-tyrosine phosphorylation!0.0136838464624472!941$GO:0032502!developmental process!0.0143908452919003!330;7128;941$GO:0006915!apoptosis!0.0145299318049594!330;7128$GO:0012501!programmed cell death!0.0145299318049594!330;7128$GO:0008219!cell death!0.0154497464175671!330;7128$GO:0016265!death!0.0154497464175671!330;7128$GO:0042108!positive regulation of cytokine biosynthetic process!0.0173298119070996!941$GO:0030217!T cell differentiation!0.0173298119070996!941$GO:0018108!peptidyl-tyrosine phosphorylation!0.017416768372748!941$GO:0018212!peptidyl-tyrosine modification!0.0177337429088587!941$GO:0001932!regulation of protein amino acid phosphorylation!0.0177337429088587!941$GO:0033238!regulation of amine metabolic process!0.0177337429088587!941$GO:0006521!regulation of amino acid metabolic process!0.0177337429088587!941$GO:0045727!positive regulation of translation!0.0200738668320086!941$GO:0048523!negative regulation of cellular process!0.0203475436230452!330;7128$GO:0008270!zinc ion binding!0.0207769642665428!330;7128;27086$GO:0048519!negative regulation of biological process!0.0209150828709926!330;7128$GO:0042035!regulation of cytokine biosynthetic process!0.0209150828709926!941$GO:0031328!positive regulation of cellular biosynthetic process!0.0209150828709926!941$GO:0042325!regulation of phosphorylation!0.0216146228805791!941$GO:0030098!lymphocyte differentiation!0.0216146228805791!941$GO:0048468!cell development!0.0216146228805791!330;7128$GO:0042089!cytokine biosynthetic process!0.021638507126761!941$GO:0042107!cytokine metabolic process!0.021638507126761!941$GO:0051174!regulation of phosphorus metabolic process!0.021638507126761!941$GO:0019220!regulation of phosphate metabolic process!0.021638507126761!941$GO:0009891!positive regulation of biosynthetic process!0.0216419680822234!941$GO:0002250!adaptive immune response!0.0228471846603561!941$GO:0002460!adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains!0.0228471846603561!941$GO:0051247!positive regulation of protein metabolic process!0.0251974450950482!941$GO:0002521!leukocyte differentiation!0.0263181054783823!941$GO:0046914!transition metal ion binding!0.0263418696564084!330;7128;27086$GO:0042110!T cell activation!0.0279032791360802!941$GO:0009968!negative regulation of signal transduction!0.0290930201859787!7128$GO:0007165!signal transduction!0.0290930201859787!330;7128;941$GO:0043122!regulation of I-kappaB kinase/NF-kappaB cascade!0.0295843340928558!7128$GO:0001816!cytokine production!0.030565078760423!941$GO:0018193!peptidyl-amino acid modification!0.0323184193172839!941$GO:0007154!cell communication!0.0346449739125504!330;7128;941$GO:0007249!I-kappaB kinase/NF-kappaB cascade!0.0362133505252718!7128$GO:0045595!regulation of cell differentiation!0.0370664343864876!941$GO:0009967!positive regulation of signal transduction!0.038909666557327!941$GO:0046649!lymphocyte activation!0.0389617623384476!941$GO:0007242!intracellular signaling cascade!0.039422872973318!7128;941$GO:0030097!hemopoiesis!0.0395500346220457!941$GO:0004842!ubiquitin-protein ligase activity!0.0398340772845374!330$GO:0008639!small protein conjugating enzyme activity!0.0398732590749438!330$GO:0005634!nucleus!0.0399241594957774!330;7128;27086$GO:0048534!hemopoietic or lymphoid organ development!0.0406484365205676!941$GO:0045321!leukocyte activation!0.041830301086174!941$GO:0002520!immune system development!0.0418461718831951!941$GO:0006417!regulation of translation!0.0418616318815704!941$GO:0031326!regulation of cellular biosynthetic process!0.0447778243296604!941$GO:0043687!post-translational protein modification!0.0452550749111929!7128;941$GO:0043169!cation binding!0.0452550749111929!330;7128;27086$GO:0001775!cell activation!0.045596969066149!941$GO:0009889!regulation of biosynthetic process!0.046856999686847!941

Revision as of 18:26, 12 September 2012


Full id: C730_migratory_cord_Mast_B_b_CD14_CD19



Phase1 CAGE Peaks

Hg19::chr11:102188181..102188222,+p1@BIRC3
Hg19::chr12:97286249..97286254,+p@chr12:97286249..97286254
+
Hg19::chr13:44272246..44272260,-p@chr13:44272246..44272260
-
Hg19::chr2:231808435..231808449,+p@chr2:231808435..231808449
+
Hg19::chr2:231808494..231808516,+p@chr2:231808494..231808516
+
Hg19::chr2:231808538..231808549,+p@chr2:231808538..231808549
+
Hg19::chr2:231808553..231808564,+p@chr2:231808553..231808564
+
Hg19::chr3:119278446..119278477,-p1@CD80
Hg19::chr3:119278493..119278513,-p3@CD80
Hg19::chr3:71114563..71114584,-p49@FOXP1
Hg19::chr6:138192133..138192144,+p19@TNFAIP3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


p.valueFDRnGenesnPathwayName
2.51303723965872e-050.0159075257270397259NOD-like receptor signaling pathway (KEGG):04621
0.0001423689371822350.0301654177358552140Regulation of toll-like receptor signaling pathway (Wikipathways):WP1449
0.0002566225776512870.03248841833065292188TNF-alpha/NF-kB Signaling Pathway (Wikipathways):WP231
0.0001906187534651180.0301654177358552162TNF alpha/NF-kB down reg. targets (Netpath):NetPath_9
0.0004387476209653280.04628787401184212246B Cell Receptor up reg. targets (Netpath):NetPath_12
0.0001745097179976610.0301654177358552155IL-1 up reg. targets (Netpath):NetPath_13



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0006916anti-apoptosis0.00846701689959302
GO:0045627positive regulation of T-helper 1 cell differentiation0.00846701689959302
GO:0043066negative regulation of apoptosis0.00846701689959302
GO:0043069negative regulation of programmed cell death0.00846701689959302
GO:0045425positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process0.00846701689959302
GO:0045625regulation of T-helper 1 cell differentiation0.00846701689959302
GO:0045624positive regulation of T-helper cell differentiation0.00846701689959302
GO:0045423regulation of granulocyte macrophage colony-stimulating factor biosynthetic process0.00846701689959302
GO:0045063T-helper 1 cell differentiation0.00846701689959302
GO:0048869cellular developmental process0.00846701689959302
GO:0030154cell differentiation0.00846701689959302
GO:0032604granulocyte macrophage colony-stimulating factor production0.00846701689959302
GO:0042253granulocyte macrophage colony-stimulating factor biosynthetic process0.00846701689959302
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB cascade0.0088037535985753
GO:0050794regulation of cellular process0.0088037535985753
GO:0045622regulation of T-helper cell differentiation0.0088037535985753
GO:0050789regulation of biological process0.0088037535985753
GO:0002294CD4-positive, alpha-beta T cell differentiation during immune response0.0088037535985753
GO:0002292T cell differentiation during immune response0.0088037535985753
GO:0042093T-helper cell differentiation0.0088037535985753
GO:0002366leukocyte activation during immune response0.0088037535985753
GO:0002285lymphocyte activation during immune response0.0088037535985753
GO:0002293alpha-beta T cell differentiation during immune response0.0088037535985753
GO:0002286T cell activation during immune response0.0088037535985753
GO:0002263cell activation during immune response0.0088037535985753
GO:0043367CD4-positive, alpha beta T cell differentiation0.00896639012394077
GO:0045086positive regulation of interleukin-2 biosynthetic process0.00896639012394077
GO:0042088T-helper 1 type immune response0.00943176012279184
GO:0065007biological regulation0.00993040632193333
GO:0042981regulation of apoptosis0.0100587672340465
GO:0043067regulation of programmed cell death0.0100587672340465
GO:0045076regulation of interleukin-2 biosynthetic process0.0100587672340465
GO:0015026coreceptor activity0.0100587672340465
GO:0042094interleukin-2 biosynthetic process0.0100587672340465
GO:0046632alpha-beta T cell differentiation0.0100587672340465
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation0.0103901080152437
GO:0046631alpha-beta T cell activation0.0112976251774761
GO:0032623interleukin-2 production0.0121571738180355
GO:0042327positive regulation of phosphorylation0.0129724438466746
GO:0045937positive regulation of phosphate metabolic process0.0136838464624472
GO:0001934positive regulation of protein amino acid phosphorylation0.0136838464624472
GO:0033240positive regulation of amine metabolic process0.0136838464624472
GO:0045764positive regulation of amino acid metabolic process0.0136838464624472
GO:0009966regulation of signal transduction0.0136838464624472
GO:0050730regulation of peptidyl-tyrosine phosphorylation0.0136838464624472
GO:0032502developmental process0.0143908452919003
GO:0006915apoptosis0.0145299318049594
GO:0012501programmed cell death0.0145299318049594
GO:0008219cell death0.0154497464175671
GO:0016265death0.0154497464175671
GO:0042108positive regulation of cytokine biosynthetic process0.0173298119070996
GO:0030217T cell differentiation0.0173298119070996
GO:0018108peptidyl-tyrosine phosphorylation0.017416768372748
GO:0018212peptidyl-tyrosine modification0.0177337429088587
GO:0001932regulation of protein amino acid phosphorylation0.0177337429088587
GO:0033238regulation of amine metabolic process0.0177337429088587
GO:0006521regulation of amino acid metabolic process0.0177337429088587
GO:0045727positive regulation of translation0.0200738668320086
GO:0048523negative regulation of cellular process0.0203475436230452
GO:0008270zinc ion binding0.0207769642665428
GO:0048519negative regulation of biological process0.0209150828709926
GO:0042035regulation of cytokine biosynthetic process0.0209150828709926
GO:0031328positive regulation of cellular biosynthetic process0.0209150828709926
GO:0042325regulation of phosphorylation0.0216146228805791
GO:0030098lymphocyte differentiation0.0216146228805791
GO:0048468cell development0.0216146228805791
GO:0042089cytokine biosynthetic process0.021638507126761
GO:0042107cytokine metabolic process0.021638507126761
GO:0051174regulation of phosphorus metabolic process0.021638507126761
GO:0019220regulation of phosphate metabolic process0.021638507126761
GO:0009891positive regulation of biosynthetic process0.0216419680822234
GO:0002250adaptive immune response0.0228471846603561
GO:0002460adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.0228471846603561
GO:0051247positive regulation of protein metabolic process0.0251974450950482
GO:0002521leukocyte differentiation0.0263181054783823
GO:0046914transition metal ion binding0.0263418696564084
GO:0042110T cell activation0.0279032791360802
GO:0009968negative regulation of signal transduction0.0290930201859787
GO:0007165signal transduction0.0290930201859787
GO:0043122regulation of I-kappaB kinase/NF-kappaB cascade0.0295843340928558
GO:0001816cytokine production0.030565078760423
GO:0018193peptidyl-amino acid modification0.0323184193172839
GO:0007154cell communication0.0346449739125504
GO:0007249I-kappaB kinase/NF-kappaB cascade0.0362133505252718
GO:0045595regulation of cell differentiation0.0370664343864876
GO:0009967positive regulation of signal transduction0.038909666557327
GO:0046649lymphocyte activation0.0389617623384476
GO:0007242intracellular signaling cascade0.039422872973318
GO:0030097hemopoiesis0.0395500346220457
GO:0004842ubiquitin-protein ligase activity0.0398340772845374
GO:0008639small protein conjugating enzyme activity0.0398732590749438
GO:0005634nucleus0.0399241594957774
GO:0048534hemopoietic or lymphoid organ development0.0406484365205676
GO:0045321leukocyte activation0.041830301086174
GO:0002520immune system development0.0418461718831951
GO:0006417regulation of translation0.0418616318815704
GO:0031326regulation of cellular biosynthetic process0.0447778243296604
GO:0043687post-translational protein modification0.0452550749111929
GO:0043169cation binding0.0452550749111929
GO:0001775cell activation0.045596969066149
GO:0009889regulation of biosynthetic process0.046856999686847



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte1.79e-57140
hematopoietic lineage restricted progenitor cell6.21e-49124
nongranular leukocyte1.58e-46119
hematopoietic stem cell2.00e-46172
angioblastic mesenchymal cell2.00e-46172
hematopoietic cell1.94e-44182
hematopoietic oligopotent progenitor cell6.45e-44165
hematopoietic multipotent progenitor cell6.45e-44165
myeloid leukocyte3.79e-2676
lymphocyte1.04e-2353
common lymphoid progenitor1.04e-2353
granulocyte monocyte progenitor cell2.88e-2371
myeloid lineage restricted progenitor cell3.10e-2370
lymphoid lineage restricted progenitor cell3.50e-2352
macrophage dendritic cell progenitor1.07e-2165
monopoietic cell1.69e-2063
monocyte1.69e-2063
monoblast1.69e-2063
promonocyte1.69e-2063
myeloid cell3.92e-20112
common myeloid progenitor3.92e-20112
CD14-positive, CD16-negative classical monocyte8.41e-1942
classical monocyte1.30e-1845
lymphocyte of B lineage5.07e-1424
pro-B cell5.07e-1424
T cell1.42e-0925
pro-T cell1.42e-0925
mature alpha-beta T cell4.10e-0818
alpha-beta T cell4.10e-0818
immature T cell4.10e-0818
mature T cell4.10e-0818
immature alpha-beta T cell4.10e-0818
B cell6.23e-0814
dendritic cell5.88e-0710
conventional dendritic cell7.92e-078
Uber Anatomy
Ontology termp-valuen
hematopoietic system6.15e-31102
blood island6.15e-31102
hemolymphoid system1.23e-30112
bone marrow5.98e-2180
immune system6.94e-19115
bone element5.68e-1786
skeletal element9.95e-12101
skeletal system9.95e-12101
blood2.00e-0715
haemolymphatic fluid2.00e-0715
organism substance2.00e-0715


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CHD2#110654.701828560962210.002363882154558910.0133963583667035
MEF2A#4205711.92751057886443.34835558215856e-071.66444030768709e-05
MYC#460973.323270281933260.001501335996249240.00959068017079174
NFKB1#4790104.989148567448943.69910541950576e-071.8223154288102e-05
POU2F2#545275.794806218563424.24433119609668e-050.000759550558240475
SPI1#668864.475085550103310.0008746501340011530.00652482752463903
TBP#690882.695833226979190.002040852110349220.0118505812049795
YY1#752873.125290477179730.002193839507732880.0126440265078149
ZBTB33#10009411.51444546544770.0002743430759209510.00292517779541686



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.