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Coexpression cluster:C805


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Full id: C805_granulocyte_acute_CD14_Eosinophils_Dendritic_Peripheral_Basophils

Phase1 CAGE Peaks


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0047696beta-adrenergic receptor kinase activity0.0211892456542427
GO:0022401adaptation of signaling pathway0.0211892456542427
GO:0002029desensitization of G-protein coupled receptor protein signaling pathway0.0211892456542427
GO:0045744negative regulation of G-protein coupled receptor protein signaling pathway0.0211892456542427
GO:0002026regulation of the force of heart contraction0.0296583952027233
GO:0004703G-protein coupled receptor kinase activity0.0458796346707017

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
hematopoietic stem cell2.14e-71172
angioblastic mesenchymal cell2.14e-71172
hematopoietic cell4.50e-68182
hematopoietic oligopotent progenitor cell2.53e-66165
hematopoietic multipotent progenitor cell2.53e-66165
nongranular leukocyte8.01e-49119
hematopoietic lineage restricted progenitor cell8.02e-49124
myeloid cell8.37e-41112
common myeloid progenitor8.37e-41112
myeloid leukocyte3.19e-2976
granulocyte monocyte progenitor cell7.53e-2771
myeloid lineage restricted progenitor cell1.97e-2570
macrophage dendritic cell progenitor2.33e-2465
monopoietic cell7.33e-2463
CD14-positive, CD16-negative classical monocyte3.34e-2242
common lymphoid progenitor1.03e-2153
lymphoid lineage restricted progenitor cell1.91e-2152
classical monocyte4.63e-2045
T cell3.11e-1125
pro-T cell3.11e-1125
mature alpha-beta T cell4.70e-1018
alpha-beta T cell4.70e-1018
immature T cell4.70e-1018
mature T cell4.70e-1018
immature alpha-beta T cell4.70e-1018
lymphocyte of B lineage6.31e-1024
pro-B cell6.31e-1024
B cell4.71e-0814
CD8-positive, alpha-beta T cell3.82e-0711
intermediate monocyte9.23e-079
CD14-positive, CD16-positive monocyte9.23e-079
Uber Anatomy
Ontology termp-valuen
hematopoietic system8.50e-33102
blood island8.50e-33102
hemolymphoid system5.29e-30112
bone marrow4.43e-2380
bone element1.60e-1986
immune system1.70e-18115
adult organism8.47e-17115
skeletal element3.08e-12101
skeletal system3.08e-12101
lateral plate mesoderm1.03e-09216
haemolymphatic fluid1.92e-0815
organism substance1.92e-0815
Ontology termp-valuen
hematologic cancer3.60e-1451
immune system cancer3.60e-1451
myeloid leukemia8.24e-1231

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs

JASPAR motifs



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)


Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.