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Coexpression cluster:C2421

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Full id: C2421_pineal_Fibroblast_cord_Keratocytes_mesenchymal_Smooth_Mesenchymal



Phase1 CAGE Peaks

  Short description
Hg19::chr17:4872581..4872600,- p@chr17:4872581..4872600
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Hg19::chr17:4872622..4872643,- p@chr17:4872622..4872643
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Hg19::chr17:4872662..4872671,- p@chr17:4872662..4872671
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Hg19::chr17:4872699..4872734,- p@chr17:4872699..4872734
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Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
animal cell3.26e-18679
eukaryotic cell3.26e-18679
fibroblast5.30e-1476
somatic cell8.53e-10588
native cell8.96e-10722
non-terminally differentiated cell9.68e-10106
contractile cell4.81e-0959
muscle cell8.35e-0955
muscle precursor cell1.11e-0858
myoblast1.11e-0858
multi-potent skeletal muscle stem cell1.11e-0858
electrically responsive cell3.13e-0761
electrically active cell3.13e-0761
smooth muscle cell4.12e-0743
smooth muscle myoblast4.12e-0743
Uber Anatomy
Ontology termp-valuen
skeletal muscle tissue2.24e-0762
striated muscle tissue2.24e-0762
myotome2.24e-0762
dense mesenchyme tissue3.08e-0773
somite3.27e-0771
presomitic mesoderm3.27e-0771
presumptive segmental plate3.27e-0771
dermomyotome3.27e-0771
trunk paraxial mesoderm3.27e-0771
muscle tissue4.62e-0764
musculature4.62e-0764
musculature of body4.62e-0764
paraxial mesoderm5.01e-0772
presumptive paraxial mesoderm5.01e-0772
epithelial vesicle6.80e-0778
multilaminar epithelium8.53e-0783


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.720743
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.244769
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.11.66718
MA0051.11.91805
MA0052.11.12718
MA0055.10.791759
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.13.06856
MA0072.11.1744
MA0073.113.7162
MA0074.10.819248
MA0076.11.51122
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.11.02755
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.931615
MA0035.20.778873
MA0039.21.13403
MA0138.20.928035
MA0002.21.75253
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.577908
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.11.1691
MA0160.10.756582
MA0161.10
MA0162.11.06783
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.122011
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105147.971147625824820.0002476385788090830.0026798389319492
EP300#203346.77394172622320.0004748459821442640.00434107488875742
FOS#235348.99795530889440.0001525147711168630.00194796260005797
FOSL2#2355416.93020060456171.2165416097647e-050.000303449699503739
GTF2F1#2962412.73966087675773.79492332235515e-050.000717743565489768
JUN#3725412.51282919233634.07770316866756e-050.00074284186504879
JUND#372746.994663941871030.000417684217818580.0039151428850076
SMARCC1#6599443.66335931963152.74744977017458e-071.40657307131011e-05
STAT3#6774410.51946499715428.16377768286615e-050.00123103779587187
TBP#690843.706770687096390.005296377814784350.0244043237712107
TFAP2A#7020416.5186343730451.34240829060362e-050.000326501582352938
TFAP2C#7022410.80922860986027.32289634782688e-050.00114524703754222



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.